Abstract
Objective
To study the association between routine childhood vaccination and the severity of COVID-19 among children.
Methods
A cross-sectional study was undertaken among 141 children (aged ≤15 years), tested positive for SARS-CoV-2 infection.
Results
COVID-19 severity (combined moderate and severe) was significantly more in males (14.5%) than females (3.8%), and in those who did not receive first and second dose of MR vaccine (57.1%, and 40%, respectively) than who received (6.3%, and 6.1%, respectively). Disease severity was more in partially immunized children (16.7%) as compared to fully immunized children (7.0%).
Conclusions
Children who did not receive both doses of MR vaccine had a severe infection when compared to those who were vaccinated.
Electronic Supplementary Material
Supplementary material is available for this article at 10.1007/s13312-022-2445-1 and is accessible for authorized users.
Keywords: Measles vaccine, SARS-CoV-2 infections
Electronic supplementary material
Web Table I Disease Outcome and Vaccination Status of Study Participants (N=141)
Contributors: MMM: data interpretation, data analysis, manuscript preparation; ALB: manuscript review, manuscript editing and definition of intellectual content; PL: concept, design, definition of intellectual content and manuscript review; MM: collection and assembling of data; KVR: facilitation of data collection and availability of data. All authors approved the final version of manuscript and are accountable for all aspects related to the study.
Funding: None
Ethics clearance: Institutional ethics committee, Maulana Azad Medical College, New Delhi; No. F.1/IEC/MAMC/80/08/2020/No-246 dated October 01, 2020.
Competing interest:: None stated.
Footnotes
Note: Additional material related to this study is available with the online version at https://www.indianpediatrics.net
References
- 1.Meena J, Yadav J, Saini L, et al. Clinical features and outcome of SARS-CoV-2 infection in children: A syste-matic review and meta-analysis. Indian Pediatr. 2020;57:820–6. doi: 10.1007/s13312-020-1961-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Ashford JW, Gold JE, Huenergardt MJA, et al. MMR vaccination: A potential strategy to reduce severity and mortality of COVID-19 illness. Am J Med. 2021;134:153–5. doi: 10.1016/j.amjmed.2020.10.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Gujar N, Tambe M, Parande M, et al. A case control study to assess effectiveness of measles containing vaccines in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children. Human Vacc Immunotherap. 2021:1–6. [DOI] [PMC free article] [PubMed]
- 4.Gold JE, Baumgartl WH, Okyay RA, et al. Analysis of measles-mumps-rubella (MMR) titers of recovered COVID-19 patients. MBio. 2020;11:e02628–20. doi: 10.1128/mBio.02628-20. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Franklin R, Young A, Neumann B, et al. Homologous protein domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that MMR vaccine might provide protection against COVID-19. 2020. medRxiv. 2020:04.10.20053207.
- 6.Escobar LE, Molina-Cruz A, Barillas-Mury C. Erratum: BCG vaccine protection from severe coronavirus disease 2019 (COVID-19) Proc Natl Acad Sci USA. 2020;117:27741–2. doi: 10.1073/pnas.2008410117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Sola AM, David AP, Rosbe KW, et al. Prevalence of SARS-CoV-2 infection in children without symptoms of coronavirus disease 2019. JAMA Pediatr. 2021;175:198–201. doi: 10.1001/jamapediatrics.2020.4095. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Ministry of Health and Family Welfare. Government of India. ClinicalManagementProtocolforCOVID19.2020. Assessed Sep 25, 2020. Available from: https://www.mohfw.gov.in/pdf/ClinicalManagementProtocolforCOVID19.pdf
- 9.Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626–38. doi: 10.1038/nri.2016.90. [DOI] [PubMed] [Google Scholar]
- 10.Kandeil A, Gomaa MR, Taweel A E, et al. Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2. PLoS One. 2020;15:1–7. doi: 10.1371/journal.pone.0241471. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Salman S, Salem ML. Routine childhood immunization may protect against COVID-19. Med Hypoth. 2020;140:109689. doi: 10.1016/j.mehy.2020.109689. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Sidiq KR, Sabir DK, Ali SM, et al. Does early childhood vaccination protect against COVID-19? Front Mol Biosci. 2020;7:1–6. doi: 10.3389/fmolb.2020.00120. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Gomber S, Arora S, Das S, et al. Immune response to second dose of MMR vaccine in Indian children. Indian J Med Res. 2011;134:302–6. [PMC free article] [PubMed] [Google Scholar]
- 14.Lundberg L, Bygdell M, Stukat von Feilitzen G, et al. Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study. Vaccine. 2021;39:4414–8. doi: 10.1016/j.vaccine.2021.06.045. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Debnath DJ, Kakkar R. Modified BG Prasad socio-economic classification, updated-2020. Indian J Comm Health. 2020;32:124–5. doi: 10.47203/IJCH.2020.v32i01.024. [DOI] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Web Table I Disease Outcome and Vaccination Status of Study Participants (N=141)
