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. 2022 Feb 23;149(4):dev200035. doi: 10.1242/dev.200035

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© 2022. Published by The Company of Biologists Ltd

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Fig. 7. — scATAC-seq revealed that hs599 exerted its function in a subpopulation of striatal MSNs. (A) Workflow of scATAC-seq of mouse LGE at E14.5. (B) Seven clusters (C0-C6) were identified and annotated according to marker gene accessibility. (C-F) UMAP plots show distinct chromatin accessibility profiles of marker genes. (G) The developmental trajectory construction scheme. (H-J) Genome tracks show normalized accessibility of three DLX1/2 binding regions with cluster-specific accessibility. Arrows represent the binding sites of DLX1/2. bRG, basal radial glial cells; Cx, cortex; IPC, intermediate progenitor cell; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; MSN, medium-sized spiny neurons; POA, preoptic area; RG, radial glial cells.