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An event is serious (based on the ICH definition) when the patient outcome is:
* death
* life-threatening
* hospitalisation
* disability
* congenital anomaly
* other medically important event
In a case series, between 16 February 2021 and 3 March 2021, 5 patients (3 women and 2 men) aged 41−66 years were described, who developed lymphadenopathy following vaccination with elasomeran or tozinameran [routes and dosages not stated].
Patient 1: A 66-year-old man, who had been diagnosed with lung cancer, received elasomeran [Moderna] vaccine into the left deltoid muscle for Covid-19. However, 22 days post vaccination, fine needle aspiration (FNA) was performed from left axillary lymph node due to suspicion of metastasis. Thus, he was diagnosed with vaccination-associated lymphadenopathy. Upon follow-up after 2 months, his lymph nodes were found to be completely regressed.
Patient 2: A 41-year-old woman, had received first dose of elasomeran vaccine into the left deltoid muscle for Covid-19. However, 3 days post vaccination, fine needle aspiration (FNA) was performed from left infraclavicular lymph node due to presence of a palpable mass. Thus, she was diagnosed with vaccination-associated lymphadenopathy. Upon follow-up after 2 months, her lymph nodes were found to be completely regressed.
Patient 3: A 47-year-old woman, had received first dose of tozinameran [Pfizer-BioN-Tech] vaccine into the left deltoid muscle for Covid-19. However, 19 days post vaccination, fine needle aspiration (FNA) was performed from left supraclavicular lymph node due to presence of a palpable mass. Thus, she was diagnosed with vaccination-associated lymphadenopathy. Upon follow-up after 2 months, her lymph nodes were found to be completely regressed.
Patient 4: A 47-year-old woman, who had been diagnosed with appendix neuroendocrine tumour (NET), had received first dose of elasomeran vaccine into the left deltoid muscle for Covid-19. However, 8 days post vaccination, fine needle aspiration (FNA) was performed from left cervical level IV lymph node due to suspicion of metastasis. Thus, she was diagnosed with vaccination-associated lymphadenopathy. Upon follow-up after 2 months, her lymph nodes were found to be completely regressed.
Patient 5: A 52-year-old man, who had been diagnosed with lung cancer, received tozinameran vaccine into the right deltoid muscle for Covid-19. However, 12 days post vaccination, fine needle aspiration (FNA) was performed from left retroclavicular lymph node due to suspicion of metastasis. Thus, he was diagnosed with vaccination-associated lymphadenopathy. Upon follow-up after 2 months, his lymph nodes were found to be completely regressed.
Reference
- Cristina H, et al. Fine needle aspiration in COVID-19 vaccine-associated lymphadenopathy. Swiss Medical Weekly 151: w20557, No. 29, 19 Jul 2021. Available from: URL: https://smw.ch/article/doi/smw.2021.20557 [DOI] [PubMed]