Dear Editor,
We would like to share ideas on the publication “Intensity of hypermetabolic axillary lymph nodes in oncologic patients in relation to timeline following COVID-19 vaccination [1].” Su et al. concluded that “Based on our preliminary results, we would recommend correlation with a history and time of vaccination and routine use of a pre-study patient questionnaire to guide interpretation to ….in oncologic patients [1].” We agree that COVID-19 vaccination can elicit a variety of physiological reactions, including adenopathy. For lymphadenopathy, an ipsilateral lymphadenopathy could be present in this situation. However, according to the current data, atypical lymphadenopathy, rather than unilateral ipsilateral adenopathy, can occur in up to 7% of cases [2]. Furthermore, we must be aware of the likelihood of a concomitant medical problem that could be overlooked [3]. According to Su et al., cautious interpretation is required to avoid false positives following immunization. A period of time should be allowed between immunization and adenopathy study [3].
References
- 1.Su N, Wiefels C, Klein R, Zeng W, Abbaspour F. Intensity of hypermetabolic axillary lymph nodes in oncologic patients in relation to timeline following COVID-19 vaccination. J Med Imaging Radiat Sci. 2022;S1939-8654:00002–00009. doi: 10.1016/j.jmir.2022.01.004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Cocco G, Delli Pizzi A, Taraschi AL, Boccatonda A, Corvino A, Ucciferri C, et al. Atypical Sites of Lymphadenopathy after Anti-COVID-19 Vaccine: Ultrasound Features. Medicina (Kaunas); 2022 Jan 27; 58(2):197. [DOI] [PMC free article] [PubMed]
- 3.Mungmunpuntipantip R, Wiwanitkit V. COVID-19 Vaccination and Subclinical Axillary Lymphadenopathy on Mammogram: Correspondence. Acad Radiol. 2021 Dec 27; 29(4):633. doi: 10.1016/j.acra.2021.12.024. Online ahead of print. [DOI] [PMC free article] [PubMed]