Abstract
Introduction
Persons living with human immunodeficiency virus (HIV) are living longer and at risk of non-communicable diseases, including diabetes mellitus (DM). Both HIV and DM place patients at risk of peripheral neuropathy (PN). Our aim was to demonstrate the prevalence and characteristics of PN in our population of patients with HIV infection compared with concomitant HIV and DM.
Methods
A prospective cross-sectional study was performed at the Aga Khan Hospital in Nairobi, Kenya. Data were collected on demographics and characteristics of DM and HIV. Symptoms and signs of PN were evaluated by Neuropathy Symptom Score, Neuropathy Disability Score, and 10 g monofilament testing.
Results
Two groups were recruited, each consisting of 68 patients: (1) HIV only, (2) HIV and DM. The median age of patients was 51 years (IQR 42.8–58.6) and 55% were male. Median duration for HIV was 10 years (IQR 5–12) with a median CD4 count of 524 cells/mm3 (IQR 369–731). Median duration for DM was 1 year with a median glycosylated hemoglobin of 6.7% (IQR 6.6–7.6). Sixty-nine percent of patients with HIV had suppressed viral loads, and 9 patients (6.6%) had a history neurotoxic antiretroviral therapy use. PN was detected in 11 (16%) HIV-only patients, and in 17 (25%) participants who had both HIV and DM (Fisher exact test chi-square = 0.4). Univariate analysis demonstrated older age, high body mass index, and long duration of HIV were associated with an OR of 1.07 (95% CI 1.02–1.11), 1.21 (95% CI 0.46–3.11), and 1.07 (95% CI 0.99–1.15) in the overall group, respectively.
Conclusion
Our study demonstrates a higher but non-significant prevalence of PN in patients with both HIV and DM when compared to HIV alone. HIV disease control had no association with PN presence.
Supplementary Information
The online version contains supplementary material available at 10.1007/s13300-022-01205-3.
Keywords: Peripheral neuropathy, HIV, Diabetes, Kenya
Key Summary Points
The prevalence of human immunodeficiency virus (HIV) is high in sub-Saharan Africa, a region which also has a huge burden of undiagnosed diabetes mellitus (DM). |
The study aimed to establish the prevalence of and risk factors for peripheral neuropathy (PN), a complication of both HIV and DM, in patients with both these chronic conditions. |
Results from the study showed a higher burden of PN in patients with both HIV and DM compared with HIV alone. |
The study identified old age, high BMI, and long duration of HIV as risk factors for development of PN in the study population. |
This forms the basis for future projects on quality of life in patients with PN and living with concurrent HIV and DM. |
Introduction
The population infected with human immunodeficiency virus (HIV) is ageing and will increasingly develop non-communicable diseases [1]. Antiretroviral therapy (ART) has lessened the burden of morbidity and mortality amongst people living with HIV [2, 3]. Prophylaxis against opportunistic infections and the prevention of mother to child transmission of HIV have resulted in increased life span of patients with HIV and higher child survival gains, respectively [4]. In Kenya, these factors have resulted in a reduction of acquired immunodeficiency syndrome (AIDS)-related deaths by 48% since 2010. The current prevalence of HIV in the country is 4.9% [5].
Noninfectious comorbidities including diabetes mellitus (DM) have a higher prevalence in HIV-positive patients than in age-matched controls [6, 7]. The prevalence of DM has been rapidly increasing in middle- and lower-income countries and it is predicted that the number of adults living with DM in Africa will more than double between 2017 and 2045. The region is also estimated to have the highest number of undiagnosed cases of DM. In Kenya, the prevalence is estimated at 2% [8].
HIV and DM demonstrate a bidirectional effect on each other. Poor glycemic control occurs in HIV-positive patients with type 2 DM [9]. A positive association has been demonstrated between antiretroviral drugs that cause lipodystrophy and the development of DM [10]. Neuropathy can occur independently in both HIV infection and DM. The main pattern of HIV infection is distal symmetric polyneuropathy (DSP) primarily of a small (c) fiber origin, which has similar features to diabetic neuropathy [11]. The prevalence of HIV neuropathy from a systematic review showed great variation with estimates ranging from 1.2% to 69.4% [12]. The proposed etiologies of DSP in HIV are peripheral nerve injury associated with the presence of HIV in the immune cells component of the peripheral nerves [13] and neurotoxic effects of antiretroviral drugs. Studies about the association among CD4 count, viral load, and risk of peripheral neuropathy (PN) have been conflicting [14, 15]. Diabetic neuropathy is the most common cause of PN worldwide [16]. DSP is a clinical diagnosis that is suggested by the presence of typical symptomatology and symmetrical distal sensory loss or typical signs in the absence of symptoms in a patient with DM [17].
The continued survival of people living with HIV predisposes them to age-related comorbidities as well as side effects from the use of ART. Many HIV neuropathy studies exclude patients with DM. Therefore, the interaction has been poorly described. This study aims to investigate the combination of risk factors demonstrated to be associated with PN in HIV with or without DM. The prevalence of neuropathy in patients will provide a basis for future investigations into the health status and quality of life amongst the growing number of age-related comorbidities in persons living with HIV/AIDS.
Methods
The study was conducted at the Aga Khan University Hospital, Nairobi (AKUHN), a private nonprofit teaching hospital. The facility has international accreditation by the Joint Commission International, and the laboratory has been accredited by the South African National Accreditation System (SANAS) and the College of American Pathologists. An average of 700 patients are followed up per year at the infectious disease clinic of the institution. CD4 counts and HIV viral load testing are performed at baseline and every 6 months. Metabolic panels including glycated hemoglobin (HbA1c), lipid profile, and renal and liver function tests are performed annually.
Study Participants
Eligible participants were at least 18 years old and assigned to one of two groups: (1) HIV positive; (2) both HIV positive and with DM. Exclusion criteria included a history of neuropathy due to non-HIV or non-diabetic cause, namely alcoholism, amyloidosis, autoimmune disorders, chronic kidney failure, connective tissue disease, infectious disease, liver failure, and vitamin B12 deficiency.
Protocol Approval and Patient Consent
Ethical approval was sought from the Institutional Ethics and Review Committee at the AKUHN (Ref. No. 2018/REC-121) prior to conducting the study. The study was conducted in accordance with the Declaration of Helsinki 1964 and its later amendments. Informed consent was signed by the participants prior to enrollment into the study.
Study Procedures
This was a prospective, cross-sectional study that enrolled patients from August 2020 to March 2021. Demographic, clinical, and laboratory data were obtained from the patient’s records. Each consenting participant was tested for the presence of PN using both a questionnaire for symptoms and clinical testing. The Neuropathy Symptom Score (NSS) (see Supplementary Material) was administered which is a validated tool to diagnose the presence and severity of neuropathy. It consists of questions probing for gait instability, burning sensation, numbness, pricking sensation and autonomic symptoms [18]. A clinical examination was undertaken by application of components of the Neuropathy Disability Score (NDS) (see Supplementary Material) and monofilament testing using a 10-g nylon filament. Neuropathy testing was performed by an internal medicine resident after training by a neurologist (D.S.) and an endocrinologist (U.A.). The NDS is a validated tool that evaluates both small and large fiber neuropathy in the lower limbs by testing the perception of pain, vibration, temperature, and ankle reflexes [1].
Peripheral neuropathy was defined as at least one neuropathy symptom on the NSS and at least one sign on either the NDS or a positive monofilament testing.
Statistical Analysis
Categorical data such as gender, ethnicity, and alcohol use are presented as frequencies and percentages, whereas continuous data such as age, body mass index (BMI), CD4 count, HIV viral load, and current HbA1c are presented as medians and interquartile ranges (IQR). Continuous data was further tested for normality using Shapiro–Wilk test. Univariate analyses were conducted using Fisher’s exact test for categorical variables and Kruskal–Wallis test for continuous variables when comparing the associations between the two groups (HIV vs HIV with DM). A logistic regression model was used to estimate the association between the risk factors and peripheral neuropathy status. The electronic database of the commercially available Statistical Package for Social Sciences (SPSS) version 25 was used to perform the analysis. Variables with a p value of less than 0.10 were included in the multivariate model whereas a p value of less than 0.05 was considered significant.
Results
A total of 150 patients were assessed for eligibility for inclusion into the study. Five patients declined consent, four were ineligible owing to meeting exclusion criteria, and five were excluded from the study because of inadequate data. Therefore 136 patients, with 68 in each study group, were included in the final analysis. Figure 1 depicts the flow of the study.
Fig. 1.
Study flowchart
Demographic Characteristics of Study Population
The median age of the participants in the HIV and DM group was higher at 55.6 years (IQR 47.2–60.4) than the 51.0 years (IQR 42.3–58.6) in the HIV only category (p < 0.001). Fifty-five percent (n = 75/136) of the total participants were male, accounting for 51.5% and 46.9% in the HIV-only and concurrent HIV and DM groups, respectively. Overall, 98.5% of the participants were Africans. The other differences in demographic characteristics are detailed in Table 1.
Table 1.
Demographic characteristics of study population
Variables | Total | HIV only | HIV + DM | P value | |||
---|---|---|---|---|---|---|---|
N = 136 | N = 68 | N = 68 | |||||
Age (years) | 51.0 | [42.3, 58.6] | 46.9 | [38.7, 53.7] | 55.6 | [47.2, 60.4] | < 0.001 |
Gender | |||||||
Male | 75 | 55.1% | 35 | 51.5% | 40 | 58.8% | 0.491 |
Female | 61 | 44.9% | 33 | 48.5% | 28 | 41.2% | |
Ethnicity | |||||||
African | 134 | 98.5% | 66 | 97.1% | 68 | 100.0% | 0.496 |
Asian | 2 | 1.5% | 2 | 2.9% | 0 | 0.0% | |
Height (cm) | 169.0 | [162.0, 174.5] | 168.0 | [160.0, 175.0] | 169.5 | [162.0, 173.0] | 0.772 |
Weight (Kg) | 75.0 | [70.0, 85.5] | 75.0 | [70.0, 85.0] | 77.5 | [70.0, 88.5] | 0.147 |
DM diabetes mellitus, HIV human immunodeficiency virus
Disease Characteristics
In the HIV-only and concurrent HIV and DM groups, the median duration since diagnosis of HIV was 8.5 (IQR 4.0–12.0) and 10.5 (IQR 6.0–13.5) years, respectively (Table 2). The current median CD4 count was 490 (IQR 356–680) and 588 (IQR 387–799) in the HIV-only and concurrent HIV and DM groups, respectively (p = 0.087). The proportion of patients with either undetectable or less than 20 copies (the laboratory cutoff range) of HIV RNA detected was 69.1%. Ninety-four percent of the total study population were on ART and only nine had a history of use of neurotoxic ART medications. In the concurrent HIV and DM group, the mean duration of period of follow-up for DM was 3.85 years. The average HBA1c was 7.65%.
Table 2.
Disease characteristics of HIV and diabetes mellitus
Variables | Total | HIV only | HIV + diabetes | P value | |||
---|---|---|---|---|---|---|---|
N = 136 | N = 68 | N = 68 | |||||
HIV duration (years) | 10.0 | [5.0, 12.0] | 8.5 | [4.0, 12.0] | 10.5 | [6.0, 13.5] | 0.071 |
CD4 count at diagnosis | 200.0 | [65.5, 400.0] | 162.5 | [50.0, 378.0] | 242.5 | [76.0, 429.5] | 0.220 |
Recent CD4 count | 524.5 | [369.0, 731.0] | 490.0 | [356.0, 680.0] | 588 | [387.5, 799.0] | 0.087 |
Recent HIV-1 RNA count | |||||||
Undetectable/< 20 | 94 | 69.1% | 48 | 70.6% | 46 | 67.6% | 0.853 |
Detectable | 42 | 30.9% | 20 | 29.4% | 22 | 32.4% | |
Current ART use | |||||||
Yes | 129 | 94.9% | 65 | 95.6% | 64 | 94.1% | 0.648 |
None | 7 | 5.1% | 3 | 4.4% | 4 | 5.9% | |
History of previous neurotoxic ART use | |||||||
Yes | 9 | 6.6% | 3 | 4.4% | 6 | 8.8% | 0.493 |
No | 127 | 93.4% | 65 | 95.6% | 62 | 91.2% | |
Duration of diabetes (years) | – | – | 1.0 | [0.5, 6.0] | – | ||
HbA1c (%) | – | – | 6.7 | [6.6, 7.6] | – | ||
Total cholesterol (mmol/L) | – | – | 4.5 | [3.7, 5.2] | – | ||
HDL cholesterol (mmol/L) | – | – | 1.1 | [0.6, 1.5] | – | ||
LDL cholesterol (mmol/L) | – | – | 2.7 | [2.2, 3.4] | – | ||
Triglycerides (mmol/L) | – | – | 1.7 | [1.2, 2.3] | – |
Data are presented as the number (%) of patients or median (25th and 75th percentile) values
ART antiretroviral therapy, HbA1c glycated hemoglobin, HDL high density lipoprotein, LDL low density lipoprotein, RNA ribonucleic acid
Prevalence of Neuropathy
Neuropathic symptoms were reported by about a third of the participants, with no significant differences in the two groups (HIV only, 33.8%; HIV and DM, 30.9%) (Table 3). The HIV and DM group had a higher proportion of detected abnormalities with 27 (39.7%) patients while the HIV-only group had 16 patients (23.5%). The most common detected abnormality on neurological examination was absent reflexes. (A detailed table of NDS findings is available in the Supplementary Material.)
Table 3.
Neuropathy Symptom Score results
Variables | Total | HIV only | HIV + diabetes | P value | |||
---|---|---|---|---|---|---|---|
N = 136 | N = 68 | N = 68 | |||||
Neuropathy symptoms | |||||||
Symptoms of unsteadiness when walking | |||||||
Yes | 6 | 4.4% | 1 | 1.5% | 5 | 7.4% | 0.208 |
No | 130 | 95.6% | 67 | 98.5% | 63 | 92.6% | |
Burning, aching pain, or tenderness in legs or feet | |||||||
Yes | 23 | 16.9% | 16 | 23.5% | 7 | 10.3% | 0.066 |
No | 113 | 83.1% | 52 | 76.5% | 61 | 89.7% | |
Pricking sensations on legs and feet | |||||||
Yes | 20 | 14.7% | 7 | 10.3% | 13 | 19.1% | 0.226 |
No | 116 | 85.3% | 61 | 89.7% | 55 | 80.9% | |
Regions of numbness on legs and feet | |||||||
Yes | 22 | 16.2% | 9 | 13.2% | 13 | 19.1% | 0.486 |
No | 114 | 83.8% | 59 | 86.8% | 55 | 80.9% | |
Polyneuropathy (≥ 1 symptom) | |||||||
Absent | 92 | 67.6% | 45 | 66.2% | 47 | 69.1% | 0.855 |
Present | 44 | 32.4% | 23 | 33.8% | 21 | 30.9% |
The diagnosis of PN required the presence of at least one symptom and at least one sign. This criterion was met by 20.6% of the participants (HIV only, 16%; HIV and DM, 25%; see Fig. 2).
Fig. 2.
Prevalence of peripheral neuropathy (percentage)
Risk Factors Associated with Neuropathy
In the overall cohort, older age, BMI and duration of HIV were not significantly associated with PN. Older age had odds ratio (OR) of 1.04; 95% confidence interval (CI) 0.979–1.102, and OR 1.09; 95% CI 1.019–1.175 in the HIV only and concurrent HIV and DM cohorts, respectively. In the HIV-only group, the period of HIV treatment had an OR 1.08 (95% CI 0.960–1.219) while the OR was 1.06 (95% CI 0.962–1.156) in the concurrent HIV and DM group. Both the CD4 count at diagnosis of HIV and the current CD4 count had no effect on the presence of neuropathy in both groups. Suppression of viral load was not associated with peripheral neuropathy in the two groups. The findings are shown in Table 4.
Table 4.
Factors associated with neuropathy
Overall (N = 136) | HIV only (N = 68) | HIV + diabetes (N = 68) | |||||||
---|---|---|---|---|---|---|---|---|---|
OR | 95% CI OR | P value | OR | 95% CI OR | P value | OR | 95% CI OR | P value | |
Age | 1.07 | [1.02, 1.113] | 0.004 | 1.04 | [0.979, 1.102] | 0.211 | 1.09 | [1.019, 1.175] | 0.014 |
Gender (female) | 0.62 | [0.263, 1.468] | 0.278 | 0.55 | [0.145, 2.094] | 0.382 | 0.72 | [0.23, 2.245] | 0.57 |
BMI (continuous) | 0.98 | [0.911, 1.053] | 0.577 | 0.99 | [0.945, 1.044] | 0.776 | 0.93 | [0.817, 1.051] | 0.238 |
BMI (underweight) | 3.89 | [0.221, 68.381] | 0.353 | – | – | – | 2.40 | [0.124, 46.391] | 0.562 |
BMI (overweight) | 1.21 | [0.469, 3.118] | 0.693 | 1.25 | [0.297, 5.256] | 0.761 | 0.98 | [0.268, 3.602] | 0.978 |
BMI (obese) | 0.58 | [0.16, 2.073] | 0.399 | 1.05 | [0.166, 6.604] | 0.962 | 0.30 | [0.049, 1.82] | 0.19 |
Duration of HIV | 1.07 | [0.996, 1.151] | 0.063 | 1.08 | [0.96, 1.219] | 0.198 | 1.06 | [0.962, 1.156] | 0.258 |
CD4 count diagnosis | 1.00 | [0.999, 1.002] | 0.699 | 1.00 | [0.998, 1.003] | 0.744 | 1.00 | [0.998, 1.002] | 0.962 |
CD4 count last | 1.00 | [0.999, 1.002] | 0.394 | 1.00 | [0.999, 1.004] | 0.287 | 1.00 | [0.999, 1.001] | 0.931 |
RNA (undetected) | 1.15 | [0.46, 2.868] | 0.767 | 0.43 | [0.114, 1.613] | 0.21 | 2.77 | [0.704, 10.905] | 0.145 |
BMI body mass index, RNA ribonucleic acid
Discussion
In view of the increasing coexistence of non-communicable disease in patients with HIV, our study aimed to show the burden of one of the complications of both HIV and DM. We identified an overall prevalence of 20.6% in the 136 participants. Comparatively, the prevalence in the HIV and DM group was higher than in the HIV-only group (25.0% and 16.2%, respectively).
The prevalence of PN in HIV has varied markedly in previous studies depending on the population studied and the diagnostic criteria utilized. Studies that have included both signs and symptoms have shown a range of prevalence of PN in HIV from 4% to 40% [15, 19–24]. Most of these reports utilized the Brief PN Screen (BPNS), a validated tool that assesses both the symptoms and signs of neuropathy [20]. The prevalence of 20.6% in the overall cohort of our study is comparable to the range exhibited in the aforementioned reports. Conversely, a high estimate of 59% was reported in Rwanda by Tumusiime et al. [25] 21% of the participants were on an ART regime containing a neurotoxic drug, stavudine, compared to our population among whom only 6.6% reported previous use.
Our study reported a higher prevalence in the HIV and DM group compared to the HIV-only group. Previous studies in the African region have either excluded patients with DM or did not have any patients with a history of DM among their participants. A study done in South Africa listed DM as an exclusion criterion due to the confounding in the diagnosis of HIV-associated PN [24]. Studies of PN in patients with HIV in Kenya [15] and Uganda [26] did not include participants with a known history of DM. Nonetheless, a history of DM was shown to confer an additional risk of PN in HIV in other reports, including Evans et al., who demonstrated an OR of 1.57 (95% CI 0.96–2.59, p = 0.080) with history of DM in asymptomatic PN and a significant association of OR 3.15 (95% CI 1.74–5.70, p = 0.001) in symptomatic PN amongst patients with HIV [19]. A different report by Anziska and colleagues reported a history of DM in 19.2% of the participants amongst women in the USA living with HIV in 2009. After multivariate analysis, DM was associated with an OR of 1.45 (95% CI 1.02–2.08, p = 0.04) in HIV DSP [27]. Similar findings were reported earlier in 2005 in a large cohort of 2515 patients in the same country with a reported OR of 1.79 (95% CI 1.12–2.84, p = 0.014 [28]. Although our study supports the notion that DM increases the risk of PN in HIV, the sampling technique does not enable analysis of the degree of risk conferred. Most of the patients with DM were diagnosed because of routine random blood sugar checks or HbA1c while undergoing follow-up for HIV infection. The relatively short duration of DM follow-up and well-controlled diabetes is a consequence of screening.
The median age was higher in the HIV and DM group compared to the HIV-only group. Older age was associated with PN with an OR of 1.04 and 1.09 in the two respective groups. This association has been clearly demonstrated in previous studies [15, 19, 23, 25, 26, 28, 29]. These results illustrate the contribution of age-related degeneration of the nerves to the insults by HIV, drugs, and other comorbid conditions like DM (duration) in the occurrence of PN. In our study, female gender was not associated with PN in HIV. This was in contrast to a study done in Kenya that showed an almost tenfold risk in female individuals [15]. The risk of PN was noted to be higher in women who were anemic, proving a possible confounder in the high risk amongst the female patients in the study. Other studies in the same region of sub-Saharan Africa in Rwanda [25] and Zimbabwe [29] showed no association between female gender and PN.
The association between the level of HIV suppression and PN has been controversial in previous studies. Advanced disease was noted to be associated with PN in studies done in the USA with CD4 counts lower than 200 conferring odds of 1.39 and 1.64, respectively [19, 28]. In contrast, no association was demonstrated between CD4 counts and PN in Kenya [15], Uganda [26], Rwanda [25], and Zimbabwe [29]. These are generally comparable to the findings of this study and supportive of the notion that other factors including nutrition may be contributory to PN in the African population. Intriguingly, in this study, a suppressed viral load has a positive impact on PN in the HIV and DM group with an OR of 2.77. This was not supportive of the postulated pathogenesis of HIV DSP as viral invasion and replication in the peripheral nerves. The potential contribution of DM as a factor in PN in this subset of patients is unclear. A longer duration of follow-up had a slight positive association with the occurrence of PN in both groups. Significant positive association between the duration of clinical follow up and PN was demonstrated in a study done in North America in 2006 [30]. More recent studies in Rwanda [25] and Nigeria [31] also show the same association.
The strengths of the study lie in the inclusion of two comparative groups in the evaluation of the burden of PN in patients with HIV. Previous reports have excluded patients with diabetes because of the confounding effect on PN. The concurrent HIV and DM group reflects the current and future challenges of comorbidities in the HIV population. Furthermore, the evaluation in relation to age, BMI, and level of disease control of both HIV and DM allowed the assessment of risk factors of PN in the participants. Most of the patients studied were attending regular follow-up clinics and therefore represent a real-world cohort of patients. The findings are therefore generalizable to many settings in Kenya and sub-Saharan Africa. The definition of PN in our study was the presence of both a symptom and a sign using validated and widely utilized criteria.
A limitation of the study was the lack of electrophysiological tests for nerve function studies and reliance on clinical evaluation for the diagnosis of PN. Nerve function tests were not administered because of financial constraints. Although we documented the prevalence of neuropathic symptoms, the burden of the disease and the impact on quality of life were not assessed. Future studies should assess how neuropathy impacts the patients.
Conclusion
Our study demonstrates a higher prevalence of PN in patients with both HIV and DM when compared to HIV alone. Physicians should consider routinely screening patients for PN in HIV-positive patients with DM.
Supplementary Information
Below is the link to the electronic supplementary material.
Acknowledgements
We thank the staff and participants at the infectious disease clinic of the Aga Khan University Hospital in Nairobi, Kenya for their cooperation during the conduct of the project. We also acknowledge the input of Aditi Vakil during data collection.
Funding
No funding or sponsorship was received for this study or publication of this article.
Authorship
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Author Contributions
Uazman Alam contributed to conception and design of the study. Jasmit Shah performed statistical analysis. Werimo Pascal Kuka, Dilraj Singh Sokhi and Reena Shah participated in data collection. All authors participated in the interpretation of the data, the writing, reviewing and editing of the manuscript, and had final responsibility for approving the published version.
Prior Presentation
This study has been earlier presented at the 25th World Neurology Congress, 3–7 October 2021 (virtual).
Disclosures
Werimo Pascal Kuka, Jasmit Shah, Uazman Alam, Dilraj Singh Sokhi and Reena Shah have nothing to disclose.
Compliance with Ethics Guidelines
All phases of this study received approval from the Institutional Ethics Review Committee of the Aga Khan University (Ref. No. 2018/REC-121). The study was conducted in accordance with the Declaration of Helsinki 1964 and its later amendments. Informed consent was obtained from all participants of this study.
Data Availability
The datasets generated during and /or analyzed during this study are available from the corresponding author on reasonable request.
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Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Data Availability Statement
The datasets generated during and /or analyzed during this study are available from the corresponding author on reasonable request.