Figure 1. Low-Dimensional Lesion Representation (Outer Circle) and Region-wise Relevance for Explaining Unfavorable 90-Day Functional Outcomes.

Six unique lesion patterns, each combining various lesion locations, represented left hemispheric stroke lesions, with varying focuses from anterior to posterior brain regions. Similar anterior to posterior dimensions were covered by right-sided lesion patterns. However, the overall spatial resolution was slightly lower for right-sided lesions, given that they were captured by only 3 individual lesion patterns. Evaluated on a region-wise basis, stroke lesions relating to bilateral precentral and postcentral gyri, insular and opercular cortex, and left putamen, caudate nucleus, and multiple white matter tracts had the highest relevance in explaining unfavorable functional outcome at 90-day (mRS score >2). Left side of images represents the left hemisphere.