Table 2.
Placental characteristics and risk of maternal all-cause mortality, CPP Mortality Linkage Study
| Placental Weight (per SD) | 1 | 1.04 (1.02,1.06) | 1.03 (1.01,1.05) |
| 2 | 0.99 (0.98,1.01) | 0.99 (0.97,1.01) | |
| 3 | 1.05 (1.02,1.07) | 1.05 (1.02,1.07) | |
| 4 | 1.05 (1.02,1.07) | 1.05 (1.02,1.07) | |
| Placenta to birthweight ratio (per SD) | 1 | 1.07 (1.04,1.09) | 1.06 (1.04,1.09) |
| 2 | 1.04 (1.01,1.07) | 1.04 (1.02,1.06) | |
| 3* | 1.03 (1.01,1.05) | 1.03 (1.01,1.05) | |
| 4* | 1.03 (1.01,1.05) | 1.03 (1.01,1.05) | |
| Largest to smallest diameter (per SD) | 1 | 1.03 (1.01,1.05) | 1.02 (1.00,1.04) |
| 2 | 1.01 (1.00,1.03) | 1.01 (0.99,1.03) | |
| 3 | 1.01 (1.00,1.03) | 1.01 (0.99,1.03) | |
| 4 | 1.01 (1.00,1.03) | 1.01 (0.99,1.03) | |
| Thickness (per SD) | 1 | 0.96 (0.94,0.98) | 0.95 (0.94,0.97) |
| 2 | 0.99 (0.98,1.01) | 1.00 (0.98,1.02) | |
| 3 | 1.00 (0.99,1.02) | 1.01 (0.99,1.03) | |
| 4 | 1.00 (0.99,1.02) | 1.01 (0.99,1.03) | |
| Placental Indices ** | |||
| Overall composite | 1 | 1.07 (1.02,1.12) | 1.05 (1.00,1.11) |
| 2 | 1.04 (0.99,1.10) | 1.04 (0.98,1.10) | |
| 3 | 1.03 (0.98,1.08) | 1.02 (0.97,1.08) | |
| 4 | 1.03 (0.98,1.08) | 1.02 (0.97,1.08) | |
| Inflammation related | 1 | 1.15 (1.10,1.20) | 1.16 (1.11,1.22) |
| 2 | 1.03 (0.99,1.08) | 1.05 (1.00,1.11) | |
| 3 | 1.01 (0.97,1.06) | 1.03 (0.98,1.09) | |
| 4 | 1.01 (0.97,1.06) | 1.03 (0.98,1.09) | |
| Hemorrhage related | 1 | 1.00 (0.94,1.06) | 0.98 (0.93,1.05) |
| 2 | 1.00 (0.94,1.06) | 1.00 (0.94,1.07) | |
| 3 | 0.98 (0.93,1.04) | 0.99 (0.92,1.05) | |
| 4 | 0.98 (0.93,1.04) | 0.99 (0.92,1.05) | |
| Hypoxia related | 1 | 0.98 (0.93,1.03) | 0.97 (0.92,1.02) |
| 2 | 1.03 (0.98,1.08) | 1.03 (0.97,1.08) | |
| 3 | 1.03 (0.98,1.08) | 1.02 (0.97,1.08) | |
| 4 | 1.03 (0.98,1.08) | 1.02 (0.97,1.08) |
Model 1: unadjusted; Model 2: age, race, composite socioeconomic status, pre-pregnancy BMI, smoking, gravidity, number of prior medical diseases, site, year of pregnancy; Model 3: model 2 + gestational age, birth weight; Model 4: model 3 + preeclampsia (*Models 3 and 4 removed additional birthweight adjustment for placenta-to-birthweight ratio models);
**
dichotomized at 90th percentile;
¥
Sensitivity analysis excluding women with diabetes or CVD conditions (including hypertension) prior to pregnancy.
Bolding denotes p<0.05.