Abstract
Rhizoma phragmitis is a common Chinese herbal medicine whose effects are defined as ‘clearing heat and fire, promoting fluid production to quench thirst, eliminating irritability, stopping vomiting, and disinhibiting urine’. During the Novel Coronavirus epidemic in 2020, the Weijing Decoction and Wuye Lugen Decoction, with Rhizoma phragmitis as the main herbal component, were included in The Pneumonia Treatment Protocol for Novel Coronavirus Infection (Trial Version 5) due to remarkable antiviral effects. Modern pharmacological studies have shown that Rhizoma phragmitis has antiviral, antioxidative, anti-inflammatory, analgesic, and hypoglycemic functions, lowers blood lipids and protects the liver and kidney. This review aims to provide a systematic summary of the botany, traditional applications, phytochemistry, pharmacology and toxicology of Rhizoma phragmitis.
Electronic Supplementary Material
Supplementary material (Appendixes 1–3) is available in the online version of this article at 10.1007/s11655-022-3572-1.
Keywords: Rhizoma phragmitis, pharmacology, phytochemistry, Chinese medicine
Electronic supplementary material
Appendix 1. Details of Prescriptions Containing Rhizoma phragmitis
Appendix 2. Main Components of Rhizoma phragmitis
Appendix 3. Pharmacological Activities of Rhizome phragmitis
Author Contributions
Ren Y drafted the manuscript. Cui GD was responsible for the literature screening and data extraction of this paper. Yao H and Zi CY were responsible for proofreading of the article. Gao YX and He LS revised and commented on the manuscript. All authors have read and approved the final version for publication.
Conflict of Interest
All the authors declare that there is no conflict of interest regarding the publication of this paper.
References
- 1.Sauvêtre A, Schröder P. Uptake of carbamazepine by rhizomes and endophytic bacteria of Phragmites australis. Front Plant Sci. 2015;6:83. doi: 10.3389/fpls.2015.00083. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.He Y, Langenhoff AAM, Sutton NB, et al. Metabolism of ibuprofen by Phragmites australis: uptake and phytodegradation. Environ Sci Technol. 2017;51:4576–4584. doi: 10.1021/acs.est.7b00458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Schröder P, Maier H, Debus R. Detoxification of herbicides in Phragmites australis. Z Naturforsch C J Biosci. 2005;60:317–324. doi: 10.1515/znc-2005-3-417. [DOI] [PubMed] [Google Scholar]
- 4.Park SJ, Kim YW, Park MK, et al. Anti-inflammatory steroid from Phragmitis Rhizoma modulates LPS-mediated signaling through inhibition of NF-κB pathway. Inflammation. 2016;39:727–734. doi: 10.1007/s10753-015-0299-6. [DOI] [PubMed] [Google Scholar]
- 5.Chen YH, Liu XC, Jiang ZP, et al. Determination of p-coumaric acid in the extract of Rhizoma phragmitis from different areas. Mod Food (Chin) 2021:196–198,201.
- 6.Wang ZH, Guo QM, Zhou FQ. Progress in chemical composition pharmacological functions development and utilization of Phragmites australis. J Liaoning Univ Tradit Chin Med (Chin) 2014;16:81–83. [Google Scholar]
- 7.da Costa RMF, Winters A, Hauck B, et al. Biorefining potential of wild-grown arundo donax, cortaderia selloana and Phragmites australis and the feasibility of white-rot fungi-mediated pretreatments. Front Plant Sci. 2021;12:679966. doi: 10.3389/fpls.2021.679966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Shin S, Kim NS, Kim YA, et al. Effect of the Phragmitis Rhizoma aqueous extract on the pharmacokinetics of docetaxel in rats. Comb Chem High Throughput Screen. 2019;22:326–332. doi: 10.2174/1386207322666190419110724. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Gao HX, Ding AW, Tang YP, et al. Chemical constituents from the Rhizomas of Phragmites communis. Chin J Nat Med. 2009;7:196–198. [Google Scholar]
- 10.Luo F. Study on the chemical constituents of Rhizoma phragmitis and the fingerprint of Kudiezi medicinal material. Shenyang: Shenyang Pharmaceutical Univisity; 2008. [Google Scholar]
- 11.Choi JS. Anti-hyperlipidemic effect of Phragmites communis and its active principles. J Korean Soc Food Sci Nutr. 1995;24:523–529. [Google Scholar]
- 12.Wang H. Analysis of volatile components of Rhizoma phragmitis and its application in cigarettes. Yunnan Chem Technol (Chin) 2008;35:62–65. [Google Scholar]
- 13.Ru JL, Li P, Wang JN, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminformatics. 2014;6:13–18. doi: 10.1186/1758-2946-6-13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Gao HX, Ding AW, Tang YP, et al. Research progress on chemical constituents, pharmacological effects and clinical applications of Rhizoma phragmitis. Res Pract Chin Med (Chin) 2009;23:75–78. [Google Scholar]
- 15.Luo F, Li N, Cao GD, et al. Isolation and identification of liposoluble components from the Rhizoma phragmitis. J Shenyang Pharm Univ (Chin) 2009;26:441–443. [Google Scholar]
- 16.Sun SL. The pharmacological effects and clinical application of the Rhizoma phragmitis. Cardiovasc Dis Electron J Integr Tradit Chin West Med (Chin) 2016;4:165. [Google Scholar]
- 17.Chen Y, Li L, Jiang LR, et al. Alkaloids constituents from the roots of Phragmites australis (Cav.) Trin. ex Steud. with their cytotoxic activities. Nat Prod Res. 2021;7:1–6. doi: 10.1080/14786419.2021.1888291. [DOI] [PubMed] [Google Scholar]
- 18.Huang GD, Chen FF, Yang JH, et al. Moschamindole induces glioma cell apoptosis by blocking Mia40-dependent mitochondrial intermembrane space assembly and oxidative respiration. Phytother Res. 2021;35:3390–3405. doi: 10.1002/ptr.7061. [DOI] [PubMed] [Google Scholar]
- 19.Grigor’eva AV, Galyautdinov IV, Khalilov LM, et al. N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-p-coumaramide from Phragmites australis. Chem Nat Compd. 2013;48:1117–1118. [Google Scholar]
- 20.Zhao XX. Preparation of polysaccharides from Chlorella vulgaris and studies on bioactive components from the Phragmites australis. Dalian: Dalian Ocean University; 2014. [Google Scholar]
- 21.Cao LH, Yang X, Zhao YY, et al. Effect of Rhizoma phragmitis on chronic bronchitis based on network pharmacology and its mechanism. Pharmacol Clin Chin Mater Med (Chin) 2021;37:96–103. [Google Scholar]
- 22.Gutiérrez Nava ZJ, Jiménez-Aparicio AR, Herrera-Ruiz ML, et al. Immunomodulatory effect of Agave tequilana evaluated on an autoimmunity like-SLE model induced in balb/c mice with pristane. Molecules. 2017;22:848–861. doi: 10.3390/molecules22060848. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Zhou R, Cui M, Wang Y, et al. Isolation, structure identification and anti-inflammatory activity of a polysaccharide from Phragmites rhizoma. Int J Biol Macromol. 2020;161:810–817. doi: 10.1016/j.ijbiomac.2020.06.124. [DOI] [PubMed] [Google Scholar]
- 24.Chung YH, Park TK, Yim SH, et al. Polysaccharide-rich extract of Phragmites Rhizome attenuates water immersion stress and forced swimming fatigue in rodent animal model. J Med Food. 2019;22:355–364. doi: 10.1089/jmf.2018.4218. [DOI] [PubMed] [Google Scholar]
- 25.Miao MS, Gu LY, Fang XY, et al. Effect of Phragmites communis polysaccharide on the aged-model mice. China J Chin Mater Med (Chin) 2004;29:673–675. [PubMed] [Google Scholar]
- 26.Qian ZG, Jiang LF. Preparation and antibacterial activity of the oligosaccharides derived from Rhizoma phragmites. Carbohydr Polym. 2014;111:356–358. doi: 10.1016/j.carbpol.2014.04.043. [DOI] [PubMed] [Google Scholar]
- 27.Zhu L, Zhang D, Yuan C, et al. Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro. Pak J Pharm Sci. 2017;30:1357–1362. [PubMed] [Google Scholar]
- 28.Cui J, Li C, Qian CJ, et al. Study on the regulatory metabolisms of Rhizoma phragmitis polysaccharide on glucolipid in diabetic mice. Farm Mach (Chin) 2012;720:142–144. [Google Scholar]
- 29.Gao D, Zhang Y, Yang F, et al. In vitro screening and evaluation of 37 traditional Chinese medicines for their potential to activate peroxisome proliferator-activated receptors-γ. Pharmacogn Mag. 2016;12:120–127. doi: 10.4103/0973-1296.177909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 30.Mazumder K, Sumi TS, Golder M, et al. Antidiabetic profiling, cytotoxicity and acute toxicity evaluation of aerial parts of Phragmites karka (Retz.) J Ethnopharmacol. 2021;270:113781. doi: 10.1016/j.jep.2021.113781. [DOI] [PubMed] [Google Scholar]
- 31.Song BH, Cheng YL, Xin XR, et al. Effects of ehanol extract of Rhizoma phragmitis on liver glycogen content and glycogen synthetase in diabetic mice. Tianjin Med J (Chin) 2014;42:65–67. [Google Scholar]
- 32.Sultan RA, Kabir MSH, Uddin MMN, et al. Ethnopharmacological investigation of the aerial part of Phragmites karka (poaceae) J Basic Clin Physiol Pharmacol. 2017;28:283–291. doi: 10.1515/jbcpp-2016-0066. [DOI] [PubMed] [Google Scholar]
- 33.Rehman AU, Liaqat M, Asghar R, et al. Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat. Bangladesh J Pharmacol. 2017;12:276. [Google Scholar]
- 34.Chen S, Ju M, Luo Y, et al. Hepatoprotective and antioxidant activities of the aqueous extract from the rhizome of Phragmites australis. Z Naturforsch C J Biosci. 2013;68:439–444. [PubMed] [Google Scholar]
- 35.Cao LH, Zhao YY, Miao JX, et al. Effect of fresh Rhizoma phragmitis on airway inflammation in chronic bronchitis based on TGF-β signaling pathway. China J Chin Mater Med (Chin) 2021;46:5887–5894. doi: 10.19540/j.cnki.cjcmm.20210824.701. [DOI] [PubMed] [Google Scholar]
- 36.Jia XD, Zhang CY, Liu YG, et al. Prevention of extract from Rhizoma phragmitis on calcium oxalate stones in male rats. Chin J Exp Tradit Med Formulae (Chin) 2013;19:224–227. [Google Scholar]
- 37.Wang Z, Yi J, Yang JY, et al. Protective effect of cadmium poisoning mice liver and kidney damage of the Rhizoma phragmitis polysaccharide. Sci Technol Food Ind (Chin) 2013;34:349–352. [Google Scholar]
- 38.Nam Y, Chung YH, Chu LY, et al. Inhibitory effects of polysaccharide-rich extract of Phragmites rhizoma on atopic dermatitis-like skin lesions in NC/Nga mice. Life Sci. 2013;92:866–872. doi: 10.1016/j.lfs.2013.03.001. [DOI] [PubMed] [Google Scholar]
- 39.Barua S, Kim H, Hong SC, et al. Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases. Arch Pharm Res. 2017;40:250–257. doi: 10.1007/s12272-016-0846-1. [DOI] [PubMed] [Google Scholar]
- 40.Kim SH, Chang WH, Lim H, et al. Aqueous extract of Phragmites communis Rhizomes attenuates phototoxicity in skin cells. Mol Cell Toxicol. 2021;17:29–40. [Google Scholar]
- 41.Kim NS, Shin S, Shin GG, et al. Genotoxicity evaluation of a Phragmitis rhizoma extract using a standard battery of in vitro and in vivo assays. J Ethnopharmacol. 2019;241:112025. doi: 10.1016/j.jep.2019.112025. [DOI] [PubMed] [Google Scholar]
- 42.Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44:450–462. doi: 10.1016/j.immuni.2016.02.015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 43.Wu DQ, Ren XF, Xu XJ, et al. Comparative study of the antioxidative capacity of ethanol extracts from different parts of Phragmites australis. Sci Technol Food Ind (Chin) 2012;33:174–176. [Google Scholar]
- 44.Abideen Z, Qasim M, Rasheed A, et al. Antioxidant activity and polyphenol content of Phragmites karka under saline conditions. Pak J Bot. 2015;47:813–818. [Google Scholar]
- 45.Kim BJ, Kim JH, Kim HP, et al. Biological screening of 100 plant extracts for cosmetic use (II): anti-oxidative activity and free radical scavenging activity. Int J Cosmet Sci. 1997;19:299–307. doi: 10.1046/j.1467-2494.1997.171726.x. [DOI] [PubMed] [Google Scholar]
- 46.Yu WJ, Jiang TF, Wang YH, et al. Determination of the monosaccharide composition of polysaccharides from Rhizoma phragmitis and Pollen typhae by capillary zone electrophoresis. Trans Oceanol Limnol (Chin) 2010:162–168.
- 47.Shen W, Ren XT, Zhang J, et al. Study on extraction and anti-oxidation of polysaccharides from Rhizoma phragmitis. Lishizhen Med Mater Med Res (Chin) 2010;21:1078–1080. [Google Scholar]
- 48.Yu XH, Xu W, Shao R, et al. Antioxidant properties of flavonoids extracted from leaves of Phragmites communis Trin. in vivo and in vitro. Food Sci. 2009;30:185–188. [Google Scholar]
- 49.Semwal DK, Bamola A, Rawat U. Chemical constituents of some antidiabetic plants. Univ J Phytochem Ayurvedic Heights. 2007;2:40–48. [Google Scholar]
- 50.Biswas B, Golder M, Islam T, et al. Comparative antioxidative and antihyperglycemic profiles of pneumatophores of two mangrove species Avicennia alba and Sonneratia apetala. Dhaka Univ J Pharm Sci. 2018;17:205–211. [Google Scholar]
- 51.Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet. 2009;373:2125–2135. doi: 10.1016/S0140-6736(09)60953-3. [DOI] [PubMed] [Google Scholar]
- 52.Wu QH, Fu SG, Song WW. Treatment of acute and chronic hepatitis with fresh Rhizoma phragmitis. Jilin J Chin Med (Chin) 1996;3:35. [Google Scholar]
- 53.Nahid S, Mazumder K, Rahman Z, et al. Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini (L.) skeels seeds: a diabetic rat model study. Asian Pac J Trop Biomed. 2017;7:126–133. [Google Scholar]
- 54.Li LH, Zhang GS. Study on the hepatoprotective effect and antihepatic fibrosis of Rhizoma phragmitis polysaccharide. J Anhui Univ Chin Med (Chin) 2007;26:32–34. [Google Scholar]
- 55.Li LH, Han GL, Gao JR, et al. Effects of Rhizoma phragmitis polysaccharide on TGF-β/Smads signaling pathway in immune liver fibrosis rats. Chin J Tradit Med Sci Technol (Chin) 2011;18:206–208. [Google Scholar]
- 56.Zhai L, Wang Z. Professor Wang Zhen’s experience in treating respiratory diseases with fresh reed rhizome. J Gansu Coll Tradit Chin Med (Chin) 2014;31:18–19. [Google Scholar]
- 57.Chen R, Luo YP, Xu XH, et al. Traditional Chinese medicine diagnosis and treatment of 52 cases of coronavirus disease (COVID-19) in Wuhan and analysis of typical medical cases. J Tradit Chin Med (Chin) 2020;61:741–744. [Google Scholar]
- 58.Xu XX. Protective effect of Rhizoma phragmitis polysaccharide on kidney in hyperlipidemia-induced rats. China Med Her (Chin) 2014;11:24–27. [Google Scholar]
- 59.Wu Y, Wang Q, Xiu CK, et al. Effect of Ginseng Radix et Rhizoma, Notoginseng Radix et Rhizoma, and Chuanxiong Rhizoma extract on mitochondrial oxidative stress in hydrogen peroxide-induced endothelial cell aging. Chin J Exp Tradit Med Formulae (Chin) 2021;27:17–24. [Google Scholar]
- 60.Leite e Silva VR, Schulman MA, Ferelli C, et al. Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices. J Cosmet Dermatol. 2009;8:32–39. doi: 10.1111/j.1473-2165.2009.00421.x. [DOI] [PubMed] [Google Scholar]
- 61.Sim MO, Ham JR, Lee MK. Young leaves of reed (Phragmites communis) suppress melanogenesis and oxidative stress in B16F10 melanoma cells. Biomed Pharmacother. 2017;93:165–171. doi: 10.1016/j.biopha.2017.06.037. [DOI] [PubMed] [Google Scholar]
- 62.Li R, Tian F, Qi Y, et al. Pegylated liposomal doxorubicin plus cyclophosphamide followed by docetaxel as neoadjuvant chemotherapy in locally advanced breast cancer (registration number: ChiCTR1900023052) Sci Rep. 2019;9:18135. doi: 10.1038/s41598-019-54387-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 63.Kim J, Lee YJ, Kim YA, et al. Aqueous extract of Phragmitis Rhizoma ameliorates myelotoxicity of docetaxel in vitro and in vivo. BMC Complement Altern Med. 2017;17:393–405. doi: 10.1186/s12906-017-1890-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 64.Hu J, Wang H, Zhang F, et al. The detoxification and synergistic effect of zingiber and Rhizoma phragmitis on radiotherapy and chemotherapy. J Taishan Med Coll (Chin) 2014;35:848–850. [Google Scholar]
- 65.Oladipo AO, Iku S, Ntwasa M, et al. Doxorubicin conjugated hydrophilic AuPt bimetallic nanoparticles fabricated from Phragmites australis: characterization and cytotoxic activity against human cancer cells. J Drug Delivery Sci Technol. 2020;57:101749. [Google Scholar]
- 66.Chao RY, Yang JY, Cai XY, et al. Extraction purification and anti-tumor activity of Rhizoma phragmitis polysaccharide. Sci Technol Food Ind (Chin) 2011;32:284–286. [Google Scholar]
- 67.Deng XJ, Ao SH. Inhibition of Rhizoma phragmitis polysaccharide on the proliferation of non-small cell lung cancer cells A549 by inducing autophagy and apoptosis. Her Med (Chin) 2020;39:1041–1046. [Google Scholar]
- 68.Zhang K, Niu GS, Deng L, et al. Effects of fresh Rhizoma phragmitis water extract on cellular immune function in mice. Tradit Chin Med Res (Chin) 2016;29:68–70. [Google Scholar]
- 69.Sun XY, Deng L, Zhao YH, et al. Effects of fresh Rhizoma phragmitis water extract on non-specific immune function in mice. Henan J Tradit Chin Med (Chin) 2016;36:1525–1527. [Google Scholar]
- 70.Chen FM, Chen GM, Ma AX, et al. Effect of Rhizoma phragmitis on immune function and blood index in the heat-stressed lactation cows. Anim Husb Vet Med (Chin) 2017;49:120–125. [Google Scholar]
Associated Data
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Supplementary Materials
Appendix 1. Details of Prescriptions Containing Rhizoma phragmitis
Appendix 2. Main Components of Rhizoma phragmitis
Appendix 3. Pharmacological Activities of Rhizome phragmitis