Table 1.
Minimal inhibitory concentrations of cefiderocol (CFDC) for 22 carbapenem-resistant Acinetobacter baumannii representative strains performed using CFDC MTS strips (Liofilchem S.r.l., 64026 Roseto degli Abruzzi TE, Italy) on Mueller–Hinton agar (cation adjusted). A. baumannii cells were cultured in LB or LB supplemented with 3.5% HSA or HPF, respectively.
| CFDC MICs (mg/L) | |||
|---|---|---|---|
| Strain | LB | HPF | 3.5% HSA |
| AB5075 | 0.5 (S) | 1 (S) | 2 (S) |
| ABUH702 | 0.38 (S) | 1.5 (S) | 3 (S) |
| AMA16 | >4.5 * (I) | >256 (R) | 32 * (R) |
| AB0057 | 1 (S) | 8 (I) | 1.5 (S) |
| AMA40 | 0.5 (S) | 16 * (R) | 3 (S) |
| AMA41 | 0.094 (S) | 0.5–0.75 (S) | 2 (S) |
| AMA113 | 0.5 (S) | 1.5 (S) | 1.5 (S) |
| AMA181 | 0.19 (S) | 0.19 (S) | 0.75 (S) |
| AMA3 | 24 (R) | >256 (R) | 32 * (R) |
| AMA4 | 16 * (R) | 48 * (R) | 64 * (R) |
| AMA5 | >256 (R) | >256 (R) | 16 * (R) |
| AMA9 | 32 (R) | 48 (R) | 16 (R) |
| AMA14 | 8 * (I) | 16 * (R) | 12 (I) |
| AMA17 | >256 (R) | >256 (R) | >256 (R) |
| AMA18 | 64 * (R) | 16 * (R) | 16 * (R) |
| AMA19 | 4 (S) | 4 (S) | 48 * (R) |
| AMA28 | 32 * (R) | >256 (R) | 32 * (R) |
| AMA30 | 64 * (R) | 128 * (R) | 12 * (I) |
| AMA31 | >256 (R) | >256 (R) | 96 * (R) |
| AMA33 | 16 * (R) | >256 (R) | >256 (R) |
* Intra-colonies are present. S: Susceptible, I: Intermediate, R: Resistant.