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. 2022 Mar 2;12(3):391. doi: 10.3390/biom12030391

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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COL11A1 modulated the expression levels of epithelial-mesenchymal transition (EMT) markers and matrix metalloproteinase (MMP)-2/9: (A) expression levels of EMT markers and MMP-2/9 were detected by Western blotting analysis in BxPC-3, Capan-2, and PANC-1 cells transfected with siCOL11A1 or pCMV3-COL11A1; (B) protein levels of EMT markers and MMP-2/9 were normalized to those of β-actin in PANC-1, BxPC-3, and Capan-2 cells after the indicated treatment; (C) expression levels of EMT markers were examined by confocal microscopy in PANC-1 cells transfected with pCMV3-COL11A1 or siCOL11A1 (×100); (D) expression levels of N-cadherin (N-cad), E-cadherin (E-cad), and vimentin (VIM) were calculated as a ratio compared with the controls (n = 3, * p < 0.05).

COL11A1 modulated the expression levels of epithelial-mesenchymal transition (EMT) markers and matrix metalloproteinase (MMP)-2/9: (A) expression levels of EMT markers and MMP-2/9 were detected by Western blotting analysis in BxPC-3, Capan-2, and PANC-1 cells transfected with siCOL11A1 or pCMV3-COL11A1; (B) protein levels of EMT markers and MMP-2/9 were normalized to those of β-actin in PANC-1, BxPC-3, and Capan-2 cells after the indicated treatment; (C) expression levels of EMT markers were examined by confocal microscopy in PANC-1 cells transfected with pCMV3-COL11A1 or siCOL11A1 (×100); (D) expression levels of N-cadherin (N-cad), E-cadherin (E-cad), and vimentin (VIM) were calculated as a ratio compared with the controls (n = 3, * p < 0.05).