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. 2022 Mar 3;10(3):601. doi: 10.3390/biomedicines10030601

Figure 8.

Figure 8

The impact of FGFR inhibitors (BGJ 398 and PD 173074) used in combination with PTX or Dox on proliferation and survival of Tx-R HCC 1806 breast cancer cells; (A) Crystal violet staining of Tx-R HCC 1806 cells that were treated with BGJ 398 (or PD 173074) alone or in combination with PTX (or Dox) for 96 h. The cells treated with DMSO were used as a control. The cells treated with PTX or Dox alone illustrated chemoresistance of Tx-R HCC 1806 cells. The culture dishes were fixed with ice-cold 100% methanol, stained with crystal violet, and photographed; (B) Quantification of crystal violet staining of Tx-R HCC 1806 cells treated with PTX and Dox alone or in combination with BGJ 398. The plates were dried, crystal violet was dissolved using 0.1% SDS solution, and absorbance was measured at 590 nm. The graphs represent the mean ± SD. * p < 0.05; ** p < 0.01; (C) Quantification of crystal violet staining of Tx-R HCC 1806 cells treated with PTX and Dox alone or in combination with PD 173074.