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. 2022 Mar 24;17(3):e0265485. doi: 10.1371/journal.pone.0265485

Effect of a multi-faceted rapid response system re-design on repeat calling of the rapid response team

Richard Chalwin 1,2,*, Amy Salter 1, Jonathan Karnon 3, Victoria Eaton 2, Lynne Giles 1
Editor: Tai-Heng Chen4
PMCID: PMC8947019  PMID: 35324935

Abstract

Background

Repeat Rapid Response Team (RRT) calls are associated with increased in-hospital mortality risk and pose an organisation-level resource burden. Use of Non-Technical Skills (NTS) at calls has the potential to reduce potentially preventable repeat calling. NTS are usually improved through training, although this consumes time and financial resources. Re-designing the Rapid Response System (RRS) to promote use of NTS may provide a feasible alternative.

Methods

A pre-post observational study was undertaken to assess the effect of an RRS re-design that aimed to promote use of NTS during RRT calls. The primary outcome was the proportion of admissions each month subject to repeat RRT calling, and the average number of repeat calls per admission each month was the secondary outcome of interest. Univariate and multivariable interrupted time series analyses compared outcomes between the two study phases.

Results

The proportion of admissions with repeat calls each month increased across both phases of the study period, but the increase was lower in the post re-design phase (change in regression slope -0.12 (standard error 0.07) post versus pre re-design). The multivariable model predicted a 6% reduction (95% confidence interval -15.1–3.1; P = 0.19) in the proportion of admissions having repeat calls at the end of the post redesign phase study compared to the predicted proportion in the absence of the re-design. The average number of calls per admission was also predicted to decrease in the post re-design phase, with an estimated difference of -0.07 calls per admission (equivalent to one fewer repeat call per 14 patients who had RRT calls) at the end of the post re-design phase (95% confidence interval -0.23–0.08, P = 0.35).

Conclusion

This study of an RRS re-design showed modest, but not statistically significant, reductions in the proportion of admissions with repeat calls and the mean number of repeat calls per admission. Given the economic and workforce capacity issues that all health care systems now face, even small improvements in the RRS may have lasting impact across the organisation. For the potential interest of RRS managers, this paper presents a pragmatic, low-cost initiative intended to enhance communication and cooperation at RRT calls.

Introduction

Over the past quarter century, the Rapid Response Team (RRT) has evolved from a conceptual advancement of the response to in-hospital cardiac arrest to become a ubiquitous patient safety mechanism [1, 2]. Throughout this time, studies, and reviews of Rapid Response System (RRS) activity have consistently demonstrated increasing rates of RRT calling, as RRS mature and the hospitals they are based within become busier [25].

In some respects, this suggests desirable awareness and utilisation of a patient safety mechanism. Indeed, the increase in RRS usage within an organisation has been associated with improved patient survival statistics [3, 6, 7]. However, increasing RRS activity poses a logistical and resourcing burden for hospitals, as most RRTs tend to not be supernumerary, with staff rostered from other substantive roles [4, 8, 9]. Although adverse effects have not yet been attributed to team members leaving other duties to attend RRT calls [10], the potential exists for these to occur. This risk could be magnified during concurrent RRT calls as resources are typically not available to provide a full response to more than one call simultaneously [9].

Against this background of increasing activity, the RRS should seek efficiencies to facilitate RRT capacity to promptly attend all unexpected clinical deteriorations. One avenue could be through reduction of potentially preventable repeat calling, that is the RRT attending a patient more than once due to inadequate resolution of an initial call, especially when the repeat call closely follows the first. In a previous study, we found increased mortality risk in patients re-attended by the RRT within 24 hours of a previous completed call in which clinical issues remained unresolved [11].

Deficits in non-technical skills (NTS), such as communication and cooperation, at RRT calls have been identified as a risk factor for potentially preventable repeat calling [1113]. Effective employment of NTS are crucial due to the inherent time and clinical pressures imposed by the deteriorating patient [14, 15]. Ideally, NTS would be augmented by delivery of specialised, simulated scenario training for RRTs [14, 16]. However, such training requires taking staff away from clinical duties, which is often not feasible in resource-limited hospitals.

Therefore, a comprehensive, multi-faceted RRS re-design aimed to enhance use of NTS at RRT calls, without the need for dedicated training or additional funding, was implemented. The re-design drew on themes from the TeamSTEPPS® program [17, 18], and previous research which described RRS improvement initiatives [14, 1921]. The present study uses Interrupted Time Series analysis to investigate the effects of the re-design of an existing RRS.

Methods

This was a pre-post intervention study assessing the proportion of patients who had repeat RRT calls before and after implementation of a RRS re-design. Data were collected over a five-year period prior to the re-design and another five years after its implementation. The present study was part of the Impact of Non-Technical Skills on Performance and Effectiveness of a Medical Emergency Team (IMPACT) research program (ClinicalTrials.gov: NCT01551160), components of which have already been reported [1113].

Participants

Patients attended by the RRT at a tertiary, outer metropolitan hospital between 1st July 2009 and 30th June 2019 were identified from RRS records. Those who were not admitted to the hospital (e.g. day procedures, outpatients, or visitors) and patients under 18 years of age were ineligible for inclusion.

The cohort of in-patient admissions who were attended by the RRT were divided into two groups: those attended by the RRT more than once during an admission (the ‘Repeat Call’ group) and those with only one RRT call.

Clinical staff were classified into two groups: those rostered to attend calls as part of the RRT (‘members’), and those who recognise clinical deterioration and call the RRT (‘users’).

Intervention

The RRS re-design incorporated three components, described in detail previously [13]. These components targeted the key NTS domains of leadership, communication, and co-operation both within the RRT and between RRT members and users.

1. Regular RRT meetings

Short meetings for RRT members, designed to address Leadership and Cooperation within the team, were scheduled to occur at the beginning of each shift. The primary purpose of these meetings was to pre-emptively establish each team member’s role and initial task at RRT calls. This approach was designed to avoid spending valuable time doing this at a deteriorating patient’s bedside.

2. Team role badges

Each member of the RRT was required to wear a badge indicating their role while attending calls. This was designed to reinforce the team Leadership role as well as facilitate non-verbal Communication of all role designations to RRT members and users present at calls.

3. RRT members-to-users”hand-off” procedure

A structured verbal and written process, aiming to improve Communication and Cooperation between RRT members and users, was introduced for RRT calls ending with the patient remaining on their ward. This formalised the transfer of primary clinical responsibility from the RRT back to the ward team. In particular, the hand-off process encouraged RRT users to voice any ongoing clinical concerns and have them addressed before the RRT departed.

Study phases

There were two phases of data collection, punctuated by the implementation of the RRS re-design as detailed above. Phase 1 comprised five years (July 2009 –June 2014) and Phase 2 a further five-year period (July 2014 –June 2019). The data presented in this paper were collected retrospectively, extracted at the end of the study from the hospital’s RRS and in-patient electronic databases.

Aside from the re-design described above, the configuration and operations of the RRS did not change over the entire study period (i.e. Phase 1 and 2). In particular, the RRT activation criteria, composition of the RRT and provision of Critical Care services at the investigating hospital remained the same throughout.

Outcome measures

RRT call data, obtained from the hospital RRS database, were aggregated at the per-patient-admission level. Variables were then created to indicate if each admission contained repeat calls, or not, and the count of those repeat calls.

The admission-level data were then collapsed by study month, derived from the date of hospital entry, with month 1 representing July 2009, through to month 120 in June 2019. A variable was created to indicate study phase (Phase 1: months 1–60, Phase 2: months 61–120).

The primary outcome in this study was the proportion of admissions with repeat RRT calls from all admissions with at least one RRT call (per month). This was chosen as an indicator of potentially preventable RRS activity that could be measured throughout both study phases.

The secondary outcome was the mean number of RRT calls per admission (from all admissions with at least one RRT call) to investigate aggregate RRT call load on the hospital.

Other variables

Demographic data, captured at time of admission, included age, gender, Indigenous identification and socioeconomic status (expressed as a binary variable for Socio-Economic Indexes for Australia (SEIFA) decile of three or less versus greater than three, derived from the 2016 Postal Area Index of Relative Socio-economic Advantage and Disadvantage) [22]. Hospital admission data included elective vs non-elective admission, Charlson Co-Morbidity Index (CCI) and in-patient length of stay (LOS). Counts of hospital admissions during each month of the study were derived from the hospital activity database.

These variables were similarly aggregated by month to account for variations in hospital activity and casemix over the study period. For each study month, the number of admissions, and the percentage of admissions corresponding to male gender, Indigenous identification, SEIFA ≤ 3, and non-elective admissions were derived. The mean age, CCI, and hospital LOS were also calculated for each study month.

Data analysis

Monthly hospital activity and aggregated patient demographics were compared between study phases using Mann-Whitney U-tests.

The effect of the re-design was assessed by Interrupted Time Series (ITS) methodology as described by Bernal et al [23]. In general terms, ITS analyses use segmented regression to compare the observed effect of an intervention, introduced at a defined time point, on an outcome to the effect predicted in the absence of the intervention [24, 25]. ITS quantified the impact of the RRS re-design on the outcomes of interest through the change in coefficients of the fitted regression line at the point of introducing the re-design.

Non-seasonal Auto Regressive Integrated Moving Average (ARIMA) models with a first-order auto-correlation were fit for each outcome variable [26]. Study month was used as the time metric in all models. Initially, simple models were fit that considered only time (study month), phase and the interaction of time and phase (i.e. a different intercept and slope corresponding to the post-intervention phase compared to the pre-intervention phase were allowed for in the regression model–see Fig 2 in Bernal et al [23]). Subsequently, multivariable models that included hospital admission rates, patient demographics and admission characteristics were fit to adjust for any variations between months in hospital activity and casemix over the study phases. The final multivariable model retained variables with a corresponding P-value < 0.1. Sensitivity analyses were also undertaken to examine the impact of potential outliers [27].

Predicted changes in the percentage of repeat call admissions and mean number of calls per admission were derived for each year using the approach outlined in Wagner et al [28]. In this way, the cumulative annual changes in the outcome measures that were attributable to the RRS design were estimated.

Model fit was assessed by the stationary R2 value, where values closer to 1 are indicative of better fit, and the Ljung-Box Q statistic, which indicates if there is a marked lack of fit of the corresponding ARIMA model [29]. Durbin’s alternative statistic was used to assess the extent of auto-correlation in the statistical models [30].

Statistical analyses were conducted with SPSS (IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp), with the exception of Durbin’s alternative statistic, which was calculated using Stata (StataCorp. 2017. Stata Statistical Software: Release 15. College Station, TX: StataCorp LLC).

Ethics

This study was approved by the Central Adelaide Health Network Human Research Committee (approval number: 2012069).

The need for patient signed consent was waived on the grounds that data used in this study were already collected electronically for hospital quality assurance purposes, no unique patient identifiers were included in the study database, and all individual patient level variables were aggregated by study month prior to analysis and reporting.

Results

The RRS database provided records for 9754 patients who were attended by the RRT during the study period. From these, 93 paediatric patients and 122 visitors, staff or outpatients were excluded as being ineligible. A further 12 in-patients for whom the database had incomplete records were also excluded. Of the remaining 9527 patient admissions, 3073 occurred in Phase 1 and 6454 in Phase 2. The hospital in-patient database recorded 188016 admissions during Phase 1 and 240910 in Phase 2.

In Phase 2, by comparison to Phase 1, there were more mean hospital admissions per month (4015 [SD 419.7] vs 3134 [SD 222.0], P<0.01) and a greater percentage of those hospital admissions were attended by the RRT (2.6% [standard deviation (SD) 0.5] versus 1.6% [SD 0.4], P<0.01).

Compared to Phase 1, in Phase 2 there were shorter mean in-patient LOS (10.9 days [SD 1.6] vs 12.9 [SD 3.0], P<0.01), lower mean patient age (67.4 [SD 2.0] vs 68.6 [SD 2.8], P<0.01), lower percentage of patients with low socioeconomic status (68.2% [SD 7.0%] vs 79.7% [SD 6.4%], P<0.01) and lower mean CCI (4.5 [SD 0.3] vs 4.8 [SD 0.46], P<0.01). Hospital activity and patient demographic data are summarised by year of the study in Table 1.

Table 1. Hospital activity and demographic data (for patients having RRT calls) by study year.

Study Year Count of All Admissions Count of RRT Call Admissions LOS Mean (SD) Age Mean (SD) Male Mean % (SD) Indigenous Mean % (SD) Low SEIFA Mean % (SD) CCI Mean (SD) Non-Elective Mean % (SD)
1 34238 507 14.4 (4.2) 67.8 (3.3) 48.7 (6.2) 0.9 (1.3) 81.7 (6.7) 4.7 (0.4) 90.8 (3.1)
2 36087 506 14.0 (3.0) 69.1 (2.8) 52.3 (9.4) 1.8 (2.0) 79.0 (6.7) 4.9 (0.5) 94.4 (2.7)
3 37785 578 11.7 (2.1) 68.9 (2.6) 51.4 (7.4) 3.0 (1.8) 82.3 (4.5) 4.8 (0.5) 93.4 (3.0)
4 39441 666 12.1 (2.2) 68.0 (3.1) 50.8 (8.7) 2.6 (1.7) 78.4 (8.2) 4.6 (0.5) 94.9 (3.2)
5 40465 816 12.6 (2.5) 69.3 (2.4) 47.9 (5.2) 1.7 (1.4) 77.0 (5.0) 4.9 (0.4) 92.9 (2.9)
Phase 1 overall 188016 3073 12.9 (3.0) 68.6 (2.8) 50.2 (7.5) 2.0 (1.8) 79.7 (6.4) 4.8 (0.5) 93.3 (3.2)
6 41098 887 11.0 (0.6) 67.2 (2.5) 52.1 (6.6) 2.4 (2.1) 74.5 (5.5) 4.7 (0.4) 92.4 (2.7)
7 45307 1174 9.9 (1.5) 65.8 (2.1) 45.7 (5.0) 1.9 (1.2) 72.4 (6.4) 4.3 (0.3) 92.0 (2.8)
8 49009 1223 11.6 (2.0) 67.8 (1.6) 49.5 (5.2) 2.0 (1.6) 65.5 (5.6) 4.4 (0.2) 94.6 (2.6)
9 52123 1541 11.5 (1.8) 68.2 (1.6) 49.7 (4.8) 3.1 (1.7) 66.6 (4.9) 4.6 (0.2) 93.2 (3.3)
10 53373 1629 10.7 (1.3) 67.9 (1.5) 49.3 (5.3) 3.6 (1.8) 61.8 (4.5) 4.6 (0.3) 93.4 (1.9)
Phase 2 overall 240910 6454 10.9 (1.6) 67.4 (2.0) 49.3 (5.6) 2.6 (1.7) 68.2 (7.0) 4.5 (0.3) 93.1 (2.7)

RRT = Rapid Response Team, SD = standard deviation, LOS = length of stay, SEIFA = socio-economic indexes for Australia, CCI = Charlson co-morbidity index.

Primary outcome

The ARIMA univariate model estimated the slope as 0.115 (standard error (SE) 0.047) in Phase 1, and 0.029 (SE 0.047) in Phase 2, indicating an observed change in slope between phases of -0.087 (SE 0.067), as shown in Fig 1.

Fig 1. Percentage of repeat call admissions per month representing the ARIMA univariate model.

Fig 1

Phase 1 monthly observed data in black squares, with slope illustrated by the solid black line. Phase 2 monthly observed data in grey circles, with slope illustrated by the solid grey line. The slope in Phase 1 is extended into Phase 2 and represented by the dotted black line for comparison with Phase 2 observed data.

Similar results were found for the final multivariable model, in which proportion of non-elective admissions and average hospital LOS were also retained as covariates. In this model, the change in slope due to the re-design was estimated to be -0.118 (SE 0.067).

The final multivariable model estimated a 6% decrease (95% confidence interval (CI)-15.1–3.1, P = 0.19) in the proportion of RRT attended patients triggering repeat calls (per month) by the fifth-year post-implementation of RRS re-design. The estimated cumulative change in the observed percentage of repeat call admissions in Phase 2, compared to the percentage predicted if the re-design had not been implemented, is shown in Fig 2.

Fig 2. Final multivariable model.

Fig 2

Cumulative predicted change in percentage of repeat call admissions (per month) associated with the RRS re-design, with 95% confidence intervals.

Durbin’s alternative test statistics were 2.35 on 1 df (P = 0.12) and 2.13 on 1 df (P = 0.14) for the univariate and multivariable models, respectively, and the stationary R2 values were 0.26 for the univariate and 0.30 for the multivariable models, respectively. The Ljung-Box Q statistic indicated there was no significant lack of fit observed for the univariate (15.77 on 17 df; P = 0.54), nor for the multivariable model (Q = 20.83 on 17 df; P = 0.23). Taken together, these statistics suggest reasonable fit of the ITS models.

Given the unusual observation in November 2015 (study month 77), a sensitivity analysis was conducted excluding this value. This analysis resulted in slightly attenuated regression coefficients for the univariate (-0.068 [SE 0.064] vs -0.087 [SE 0.067]) and multivariable models (-0.094 [SE 0.065] vs -0.118 [SE 0.067]), and a modest alteration of the estimated change in percentage of patients having repeat calls versus predicted to -4.9% (95% CI -13.7–3.8, P = 0.27) as shown in S1 Fig.

Secondary outcome

The change in regression coefficient for the mean number of calls per admission in Phase 2 compared to Phase 1 associated with implementation of the re-design was -0.001 (SE 0.001) in the ARIMA univariate model. Fig 3 shows the observed data for Phase 1 and Phase 2.

Fig 3. Mean number of calls per admission by study month for the ARIMA univariate model.

Fig 3

Phase 1 observed data in black squares, with slope illustrated by the solid black line. Phase 2 observed data in grey circles, with slope illustrated by the solid grey line. The Phase 1 slope is extended into Phase 2 and represented by the dotted black line for comparison with Phase 2 observed data.

At the end of the Phase 2, the final multivariable model, retaining hospital LOS, showed a predicted difference of -0.07 (95%CI -0.23–0.08) calls per admission (P = 0.35) as shown in Fig 4.

Fig 4. Final multivariable model.

Fig 4

Cumulative predicted change in calls per admission associated with the RRS re-design, with 95% confidence intervals.

The fit statistics from the ITS models for the calls per admission were similar to those observed in the analysis of the primary outcome, again suggesting reasonable fit. Durbin’s alternative test statistics were 0.68 on 1 df (P = 0.41) and 0.58 on 1 df (P = 0.45) for the univariate and multivariable models, respectively. The stationary R2 values were 0.26 for the univariate and 0.30 for the multivariable models. The Ljung-Box Q statistic indicated there was no significant lack of fit for the univariate (12.83 on 17 df; P = 0.75), nor for the multivariable model (Q = 15.82 on 17 df; P = 0.54).

A sensitivity analysis excluding the unusual November 2015 observation led to results that were essentially unchanged, with the pre-post regression coefficient change in slope of -0.001 [SE 0.001] and 0.07 fewer predicted calls per admission (95%CI -0.21–0.07, P = 0.34), as presented in the final multivariable model in S2 Fig.

Discussion

Key findings

Following a multi-faceted RRS re-design, modest, but not statistically significant, reductions were estimated in the percentage of RRT-attended patients having repeat calls and the average number of repeat RRT calls per patient, with changes in hospital activity and patient demographics accounted for in the statistical analyses. The observed reduction saw six percent fewer RRT attended patients going on to have repeat calls (per month). In the context of a median 30-minute call duration [12], this would be equivalent to a reduction in RRS activity of three hours per 100 patients attended by the RRT.

Interpretation of results

Notably, the investigating hospital saw markedly increased activity throughout the study period. This partly explains the disparity in the number of subjects between the two study Phases. However, there was also a statistically significant increase in the percentage of admissions subject to RRT calls in Phase 2 versus Phase 1. Reviews of RRS operational activity observations have reported that increases in RRT calling over time following introduction of an RRS are commonplace [17]. A likely cause is familiarity and acceptability that reduce barriers to calling as the RRS matures.

In this study, the changes in hospital activity and patient demographics were accounted for in the multivariable Interrupted Time Series analyses. The estimated reduction in proportion of patients experiencing a repeat call following the RRS re-design has potential implications for patient mortality. A previous publication from this research program and two other studies corroborated the association between repeat calling and mortality [12, 31, 32].

Implications of results

For organisations, there are two important potential benefits to operational efficiency from exploring potentially avoidable repeat calling. First, RRTs tend to draw resources from other acute clinical unit rosters, such as ICU and Internal Medicine, rather than have their own supernumerary staffing [8, 9]. Therefore, even modest reductions in potentially avoidable re-calling of the RRT allow staff more time to attend to their primary rostered clinical duties.

Second, as RRS activity increases, there is a proportionate potential for concurrent RRT calls. Most RRS only roster a single RRT [8, 9], which presents a risk to simultaneously deteriorating patients from delayed or incomplete attendance by an RRT. Thus, attempts to reduce the likelihood of avoidable repeat calls may help to ensure constant RRS capability to attend clinical deterioration promptly and effectively.

Contribution to evidence base

The literature on re-designing the RRS to improve use of NTS during RRT calls is scant. Most published articles reinforce simulation training as the gold standard mechanism to achieve this [14, 15]. Staff training is labour and cost intensive, so alternative strategies need to be explored.

Kansal et al. evaluated streamlining information sharing by ward staff to the RRT on their arrival to calls, alongside other restructuring of their respective RRS [19]. Although they did report reductions in rates of unexpected deaths and other adverse patient outcomes after re-designing the RRS, these authors could not ascribe the role of the enhanced handover as the sole reason for these improvements due to changes to a tiered RRS response taking place at the same time.

Prince et al. and Mardegan et al. described changes to operations of the RRT during calls [20, 21]. Prince et al. focused on visual identification of team member roles during cardiac arrest calls which was incorporated into simulation training for the RRT. These authors noted perceived improvements in communication during RRT calls, although no pre-training data were collected. This reflects improvements in perceptions and experiences of interactions during RRT calls we found in a previous publication from this research program [13]. Mardegan et al. only described staff satisfaction after introduction of a RRT call checklist that facilitated handover from ward staff to the RRT on their arrival to calls. While staff were positive in general about each of these interventions, no effects on patient outcomes were presented in either study [20, 21].

The present study reports implementation of a multi-faceted RRS re-design that aimed to promote use of NTS during RRT calls. While not statistically significant, the results may still be worthy of consideration at an organisational level, especially given the negligible barriers or overheads to implementing the three components of this RRS re-design.

Strengths and limitations

To the best of our knowledge, this is the first description of objective RRS performance outcomes measured around implementation of a Non-Technical Skills focused system re-design.

The Interrupted Time Series approach is particularly helpful for studying organisation-level interventions where randomised controlled trials are infeasible [2325]. Its use in this study allowed us to investigate the effect of the re-design on the outcomes and accounted for temporal trends and variations [28]. The analysis also demonstrated that the effect of the re-design in reducing rates of repeat calling was sustained throughout Phase 2, with no evidence of attrition of benefit.

As with any pragmatic study, there are limitations. First, we acknowledge the absence of results regarding RRS compliance with the components of the re-design, or usage of NTS during RRT calls. Due to limited financial resources for the study, it was not possible to employ observers to objectively record attendance at RRT meetings, wearing of badges or usage of NTS during RRT calls, and adherence to the required hand-off process at RRT call completions.

Second, although a range of demographic and hospital activity co-variates were included in the analyses and the configuration of RRS did not otherwise alter during the entire study period, it is still possible that some other unmeasured factors, such as seniority of RRT clinicians, could have influenced the findings.

Finally, some repeat calls may indicate a correctly functioning RRS responding to clinically discrete deteriorations. However, this study focused on the wider resourcing implication for organisations, and so did not separate these from the preventable calls. All repeat calls present a potential logistical and staffing burden on hospitals, so that even modest improvements, such as observed here, may confer benefits to the organisation.

Future scope for re-designing the RRS

The RRS re-design used in this study was developed with the understanding that further iteration and re-evaluation would be worthwhile. Some potential revisions to the re-design, such as role stickers, rather than badges, and electronic availability of RRT rosters, have already been proposed in a previous publication from this research program [13].

Further to those, a natural addition to the RRS would be debriefs for the RRT and other hospital staff involved in calls [33, 34]. This could take one of two forms: “hot debrief” conducted immediately after completion of each RRT call or “cold debrief” in which cases are reviewed later at scheduled meetings [34]. There are challenges in implementing either of these debrief methods. Hot debrief depends on RRT members, and possibly also ward staff, involved in that call remaining available to attend. For ad-hoc RRTs rostered from other clinical roles, this may be infeasible [8, 9]. The scheduled, delayed nature of cold debrief provides more opportunity for RRT members to plan their attendance and avoid conflicts with other clinical duties, so may be easier to implement, but all RRT members are unlikely to be rostered to work at the scheduled time of the cold debrief [34].

Context within the IMPACT research project

As outlined earlier, this study was conducted as part of a larger research project. In a parallel survey study of perceptions and experiences of NTS use during RRT calls of RRT members and those calling the RRT (users), this RRS re-design was associated with significant reductions in reported experience of conflict [13]. Furthermore, both in quantitative data and free-text comments, improvements in leadership, communication and cooperation between RRT members and users during RRT calls were reported following introduction of the re-design.

Thus, the apparent lack of effect of the RRS re-design on the proportion of admissions with repeat RRT calls and the mean number of RRT calls per admission raises the question of whether organisational change did not occur, or whether a potential improvement (as suggested by the survey findings) was not captured by the outcomes used here. Therefore, as part of future research, identification and use of other outcome measures that are more sensitive to NTS performance during RRT calls should be explored.

Conclusions

This study reports a multi-faceted RRS re-design which was associated with a modest, but not statistically significant, reduction in the percentage of patients per month having repeat calls and the average number of repeat calls per admission.

In an era of economic and health workforce constraints, even small potential improvements may still have relevance to organisations. This RRS re-design (and assessment thereof) has scope for further refinement, and may be of interest to RRS clinicians and managers seeking to implement their own pragmatic, low-cost quality improvement initiatives.

Supporting information

S1 Fig. Percentage of repeat call admissions per month representing the ARIMA univariate model with outlier detection enabled.

Phase 1 observed data shown as black squares, with trend shown as the solid black line. Phase 2 observed data shown as grey circles, with trend shown as the solid grey line. The Phase 1 trend is extended into Phase 2 as the dotted black line for comparison with Phase 2 observed data. Observation for study month 77 (November 2015) was identified as an outlier and excluded for this sensitivity analysis.

(TIF)

S2 Fig. Mean number of calls per admission by study month for the ARIMA univariate model with outlier detection enabled.

Phase 1 observed data shown as black squares, with trend shown as the solid black line. Phase 2 observed data shown as in grey circles, with trend shown as the solid grey line. The Phase 1 trend is extended into Phase 2 as the dotted black line for comparison with Phase 2 observed data. Observation for study month 77 (November 2015) was identified as outlier and excluded for this sensitivity analysis.

(TIF)

S1 Data. De-identified, by-month aggregated data used in statistical analyses.

(CSV)

Acknowledgments

Dr Bill Wilson, Chief Medical Information Officer, Northern Adelaide Local Health Network, Adelaide, Australia for assistance with data extraction from hospital electronic databases.

Data Availability

All relevant data are within the manuscript and its Supporting Information files.

Funding Statement

The author(s) received no specific funding for this work.

References

  • 1.Jones DA, DeVita MA, Bellomo R. Rapid-response teams. N Engl J Med 2011;365:139–146. doi: 10.1056/NEJMra0910926 [DOI] [PubMed] [Google Scholar]
  • 2.Chan PS, Jain R, Nallmothu BK, Berg RA, Sasson C. Rapid Response Teams: A Systematic Review and Meta-analysis. Arch Intern Med. 2010;170:18–26. doi: 10.1001/archinternmed.2009.424 [DOI] [PubMed] [Google Scholar]
  • 3.Herod R, Frost SA, Parr M, Hillman K, Aneman A. Long term trends in medical emergency team activations and outcomes. Resuscitation 2014;85:1083–1087. doi: 10.1016/j.resuscitation.2014.04.010 [DOI] [PubMed] [Google Scholar]
  • 4.The Joint College of Intensive Care Medicine and Australian and New Zealand Intensive Care Society Special Interest Group on Rapid Response Systems. Resource use, governance and case load of rapid response teams in Australia and New Zealand in 2014. Crit Care Resusc 2016;18:275–282. [PubMed]
  • 5.College of Intensive Care Medicine of Australia and New Zealand; Australian and New Zealand Intensive Care Society. Joint position statement on rapid response systems in Australia and New Zealand and the roles of intensive care. (IC-25) Melbourne: CICM; 2016.
  • 6.Jones D, Bellomo R, Devita M. Effectiveness of the Medical Emergency Team: the importance of dose. Crit Care 2009;13:313. doi: 10.1186/cc7996 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Hillman K, Chen J, Jones D. Rapid response systems. Med J Aust 2014;201:519–521. doi: 10.5694/mja14.01088 [DOI] [PubMed] [Google Scholar]
  • 8.The ANZICS-CORE MET dose Investigators. Rapid Response Team composition, resourcing and calling criteria in Australia. Resuscitation 2011;83:563–567. doi: 10.1016/j.resuscitation.2011.10.023 [DOI] [PubMed] [Google Scholar]
  • 9.Sethi SS, Chalwin R. Governance of rapid response teams in Australia and New Zealand. Anaesth Intensive Care 2018;46:304–312. doi: 10.1177/0310057X1804600308 [DOI] [PubMed] [Google Scholar]
  • 10.Concord Medical Emergency Team (MET) Incidents Study Investigators Incidents resulting from staff leaving normal duties to attend medical emergency team calls. Med J Aust 2014;201:528–531. doi: 10.5694/mja14.00647 [DOI] [PubMed] [Google Scholar]
  • 11.Chalwin R, Flabouris A, Kapitola K, Dewick L. Perceptions of interactions between staff members calling, and those responding to, rapid response team activations for patient deterioration. Aust Health Rev. 2016;40:364–370. doi: 10.1071/AH15138 [DOI] [PubMed] [Google Scholar]
  • 12.Chalwin R, Giles L, Salter A, Eaton V, Kapitola K, Karnon J. Reasons for Repeat Rapid Response Team Calls, and Associations with In-Hospital Mortality. Jt Comm J Qual Patient Saf 2019;45:268–275. doi: 10.1016/j.jcjq.2018.10.005 [DOI] [PubMed] [Google Scholar]
  • 13.Chalwin R, Giles L, Salter A, Kapitola K, Karnon J. Re-designing a rapid response system: effect on staff experiences and perceptions of rapid response team calls. BMC Health Serv Res 2020;20:480. doi: 10.1186/s12913-020-05260-z [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Gillon S, Radford S, Chalwin R, Devita M, Endacott R, Jones D. Crisis resource management, simulation training and the medical emergency team. Crit Care Resusc 2012;14:227–235. [PubMed] [Google Scholar]
  • 15.Chalwin RP, Flabouris A. Utility and assessment of non-technical skills for rapid response systems and medical emergency teams. Intern Med J 2013;43:962–969. doi: 10.1111/imj.12172 [DOI] [PubMed] [Google Scholar]
  • 16.Flin R, Maran N. Identifying and training non-technical skills for teams in acute medicine. Qual Saf Health Care 2004;13(Suppl 1):i80–84. doi: 10.1136/qhc.13.suppl_1.i80 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Clancy CM, Tornberg DN. TeamSTEPPS: assuring optimal teamwork in clinical settings. Am J Med Qual 2007;22:214–217. doi: 10.1177/1062860607300616 [DOI] [PubMed] [Google Scholar]
  • 18.King HB, Battles J, Baker DP, Alonso A, Salas E, Webster J, et al. TeamSTEPPS™: Team Strategies and Tools to Enhance Performance and Patient Safety. In: Henriksen K, Battles JB, Keyes MA, Grady ML, editors. Advances in Patient Safety: New Directions and Alternative Approaches (Vol. 3: Performance and Tools). Rockville (MD): Agency for Healthcare Research and Quality (US);2008. Aug. [PubMed] [Google Scholar]
  • 19.Kansal A, Havill K. The effects of introduction of new observation charts and calling criteria on call characteristics and outcome of hospitalised patients. Crit Care Resusc 2012;14:38–43. [PubMed] [Google Scholar]
  • 20.Prince CR, Hines EJ, Chyou PH, Heegeman DJ. Finding the key to a better code: code team restructure to improve performance and outcomes. Clin Med Res 2014;12:47–57. doi: 10.3121/cmr.2014.1201 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Mardegan K, Heland M, Whitelock T, Millar R, Jones D. Developing a medical emergency team running sheet to improve clinical handoff and documentation. Jt Comm J Qual Patient Saf 2013;39:570–575. doi: 10.1016/s1553-7250(13)39073-4 [DOI] [PubMed] [Google Scholar]
  • 22.Australian Bureau of Statistics. 2033.0.55.001—Census of Population and Housing: Socio-Economic Indexes for Areas (SEIFA), Australia, 2016. Accessed at: https://www.abs.gov.au/AUSSTATS/abs@.nsf/DetailsPage/2033.0.55.0012016?OpenDocument in June 2020.
  • 23.Bernal JL, Cummins S, Gasparrini A. Interrupted time series regression for the evaluation of public health interventions: a tutorial. Int J Epidemiol 2017;46:348–355. doi: 10.1093/ije/dyw098 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Fretheim A, Zhang F, Ross-Degnan D, Oxman AD, Cheyne H, Foy R et al. A reanalysis of cluster randomized trials showed interrupted time-series studies were valuable in health system evaluation. J Clin Epidemiol 2015;68:324–333. doi: 10.1016/j.jclinepi.2014.10.003 [DOI] [PubMed] [Google Scholar]
  • 25.Kontopantelis E, Doran T, Springate DA, Buchan I, Reeves D. Regression based quasi-experimental approach when randomisation is not an option: interrupted time series analysis. BMJ 2015;350:h2750. doi: 10.1136/bmj.h2750 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Nelson BK. Time series analysis using autoregressive integrated moving average (ARIMA)models. Acad EmergMed 1998;5:739–44. doi: 10.1111/j.1553-2712.1998.tb02493.x [DOI] [PubMed] [Google Scholar]
  • 27.Tsay RS. Outliers, level shifts, and variance changes in time series. J Forecast 1988;7:1–20 [Google Scholar]
  • 28.Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther. 2002;27:299–309. doi: 10.1046/j.1365-2710.2002.00430.x [DOI] [PubMed] [Google Scholar]
  • 29.Ljung GM, Box GE. On a Measure of a Lack of Fit in Time Series Models. Biometrika 1978;65:297–303. [Google Scholar]
  • 30.Baum C.F, Wiggins VL.sg135: Test for autoregressive conditional heteroskedasticity in regression error distribution. Stata Technical Bulletin 2000;55:13–14. Reprinted in Stata Technical Bulletin Reprints, vol. 10, pp. 143–4. College Station, TX: Stata Press.
  • 31.Calzavacca P, Licari E, Tee A, Mercer I, Haase M, Haase-Fielitz A et al. Features and outcome of patients receiving multiple Medical Emergency Team reviews. Resuscitation 2010;81:1509–1515. doi: 10.1016/j.resuscitation.2010.06.017 [DOI] [PubMed] [Google Scholar]
  • 32.Stelfox HT, Bagshaw SM, Gao S. Characteristics and outcomes for hospitalized patients with recurrent clinical deterioration and repeat medical emergency team activation. Crit Care Med 2014;42:1601–1609. doi: 10.1097/CCM.0000000000000315 [DOI] [PubMed] [Google Scholar]
  • 33.Aponte-Patel L, Salavitabar A, Fazzio P, Geneslaw AS, Good P, Sen AI. Implementation of a Formal Debriefing Program After Pediatric Rapid Response Team Activations. J Grad Med Educ 2018;10:203–208. doi: 10.4300/JGME-D-17-00511.1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Couper K, Perkins GD. Debriefing after resuscitation. Curr Opin Crit Care 2013;19:188–194. doi: 10.1097/MCC.0b013e32835f58aa [DOI] [PubMed] [Google Scholar]

Decision Letter 0

Tai-Heng Chen

14 Oct 2021

PONE-D-21-18171

Effect of a multi-faceted Rapid Response System re-design on repeat calling of the Rapid Response Team

PLOS ONE

Dear Dr. Chalwin,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Nov 27 2021 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Tai-Heng Chen, M.D.

Academic Editor

PLOS ONE

Journal requirements:

When submitting your revision, we need you to address these additional requirements.

1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at

https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf and

https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf

2. In your Data Availability statement, you have not specified where the minimal data set underlying the results described in your manuscript can be found. PLOS defines a study's minimal data set as the underlying data used to reach the conclusions drawn in the manuscript and any additional data required to replicate the reported study findings in their entirety. All PLOS journals require that the minimal data set be made fully available. For more information about our data policy, please see http://journals.plos.org/plosone/s/data-availability.

Upon re-submitting your revised manuscript, please upload your study’s minimal underlying data set as either Supporting Information files or to a stable, public repository and include the relevant URLs, DOIs, or accession numbers within your revised cover letter. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories. Any potentially identifying patient information must be fully anonymized.

Important: If there are ethical or legal restrictions to sharing your data publicly, please explain these restrictions in detail. Please see our guidelines for more information on what we consider unacceptable restrictions to publicly sharing data: http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions. Note that it is not acceptable for the authors to be the sole named individuals responsible for ensuring data access.

We will update your Data Availability statement to reflect the information you provide in your cover letter.

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a) If there are ethical or legal restrictions on sharing a de-identified data set, please explain them in detail (e.g., data contain potentially sensitive information, data are owned by a third-party organization, etc.) and who has imposed them (e.g., an ethics committee). Please also provide contact information for a data access committee, ethics committee, or other institutional body to which data requests may be sent.

b) If there are no restrictions, please upload the minimal anonymized data set necessary to replicate your study findings as either Supporting Information files or to a stable, public repository and provide us with the relevant URLs, DOIs, or accession numbers. For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories.

We will update your Data Availability statement on your behalf to reflect the information you provide.

4. Your ethics statement should only appear in the Methods section of your manuscript. If your ethics statement is written in any section besides the Methods, please delete it from any other section.

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Partly

Reviewer #3: Yes

********** 

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

********** 

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

********** 

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

********** 

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: 1. Cite the source (reference) when models proposed by other researchers are mentioned.

2. Conclusion- Need major revision. Should include the key findings, answer the research questions, highlight the limitations, and future scope, etc.

3. Interpretation of Results: Use the reference numbers instead of author names.

Reviewer #2: The manuscript is technically sound and the statistical analyses performed are appropriate. Just one question regarding the conclusion, I could not understand how your findings are 'suggestive of feasibility' of a redesign. Please kindly elaborate on that.

Please edit the article for grammar. There are numerous minor grammatical errors; there is no easy way to list them all here.

As examples: In the abstract:

Background: ...training; however, this...

Methods:... effect of AN RRS re-design.

Reviewer #3: Dear Author(s)

The design of the study is original, well-defined problems, and clearly reveals the purpose or hypothesis. Methods and practices are clear and understandable. The findings are discussed appropriately and adequately. The language of writing is clear and grammatically well written. My suggestion is to accept as it.

Best Regards

********** 

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2022 Mar 24;17(3):e0265485. doi: 10.1371/journal.pone.0265485.r002

Author response to Decision Letter 0


2 Nov 2021

Reviewer 1 Comments

1. “Cite the source (reference) when models proposed by other researchers are mentioned”

A reference is provided for ARIMA statistical modelling. The Cochrane (EPOC) reference has been updated to an original description of the segmented regression Interrupted Time Series analytical technique used.

2. “Conclusion- Need major revision”

The conclusion has been rewritten per your request to include the key findings and scope for future research. It now reads:

This study reports a multi-faceted RRS re-design which did not demonstrate a statistically significant effect on the percentage of patients per month having repeat calls or the number of repeat calls per admission.

The RRS re-design presented herein may be of interest to RRS clinicians and managers as a pragmatic, low-cost quality improvement initiative that could inspire future efforts to improve operational efficiency of the RRS.

3. “Interpretation of Results: Use the reference numbers instead of author names”

The names of the lead authors of the two cited papers have been removed.

Reviewer 2 Comments

1. “I could not understand how your findings are 'suggestive of feasibility' of a redesign”

That statement in Conclusions has been removed. The comment regarding the re-design has been rewritten to better reflect the potential contribution of the study to future research.

The conclusion now reads:

This study reports a multi-faceted RRS re-design which did not demonstrate a statistically significant effect on the percentage of patients per month having repeat calls or the number of repeat calls per admission.

The RRS re-design presented herein may be of interest to RRS clinicians and managers as a pragmatic, low-cost quality improvement initiative that could inspire future efforts to improve operational efficiency of the RRS.

2. “Please edit the article for grammar”

We have thoroughly perused the manuscript and used Microsoft Word grammar checks. Errors have been corrected per PLOS One style and language requirements.

Reviewer 3 Comments

None to address

Attachment

Submitted filename: Response to Reviewers.docx

Decision Letter 1

Tai-Heng Chen

19 Dec 2021

PONE-D-21-18171R1Effect of a multi-faceted Rapid Response System re-design on repeat calling of the Rapid Response TeamPLOS ONE

Dear Dr. Chalwin,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process. Please submit your revised manuscript by Feb 02 2022 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Tai-Heng Chen, M.D.

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Conclusion: Need revision.

A conclusion should address: answers research questions/objectives; explains discrepancies and unexpected findings; states importance of discoveries and future implications.

Reviewer #2: The study is methodologically sound and the authors have revised the manuscript to adequately address the concerns I had.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: R. S. Ajin

Reviewer #2: No

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2022 Mar 24;17(3):e0265485. doi: 10.1371/journal.pone.0265485.r004

Author response to Decision Letter 1


20 Jan 2022

Reviewer 1 Comments

1. “Conclusion: Need revision. A conclusion should address: answers research questions/objectives; explains discrepancies and unexpected findings; states importance of discoveries and future implications.”

The conclusions of both the abstract and manuscript have been thoroughly revised and rewritten per your request to clarify the study objectives, key findings, discrepancies and the scope for iterative research and quality improvement.

The abstract conclusion now reads:

“This study of an RRS re-design showed modest, but not statistically significant, reductions in the proportion of admissions with repeat calls and the mean number of repeat calls per admission. Given the economic and workforce capacity issues that all health care systems now face, even small improvements in the RRS may have lasting impact across the organisation. For the potential interest of RRS managers, this paper presents a pragmatic, low-cost initiative intended to enhance communication and cooperation at RRT calls.”

The manuscript conclusion now reads:

“This study reports a multi-faceted RRS re-design which was associated with a modest, but not statistically significant, reduction in the percentage of patients per month having repeat calls and the average number of repeat calls per admission.

In an era of economic and health workforce constraints, even small potential improvements may still have relevance to organisations. This RRS re-design (and assessment thereof) has scope for further refinement, and may be of interest to RRS clinicians and managers seeking to implement their own pragmatic, low-cost quality improvement initiatives.”

Reviewer 2 Comments

None to address

Attachment

Submitted filename: Response to Reviewers Comments.docx

Decision Letter 2

Tai-Heng Chen

3 Mar 2022

Effect of a multi-faceted Rapid Response System re-design on repeat calling of the Rapid Response Team

PONE-D-21-18171R2

Dear Dr. Chalwin,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Tai-Heng Chen, M.D.

Academic Editor

PLOS ONE

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: All the comments have been properly addressed by the authors. My decision is to accept the manuscript.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Acceptance letter

Tai-Heng Chen

8 Mar 2022

PONE-D-21-18171R2

Effect of a multi-faceted Rapid Response System re-design on repeat calling of the Rapid Response Team

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Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Fig. Percentage of repeat call admissions per month representing the ARIMA univariate model with outlier detection enabled.

    Phase 1 observed data shown as black squares, with trend shown as the solid black line. Phase 2 observed data shown as grey circles, with trend shown as the solid grey line. The Phase 1 trend is extended into Phase 2 as the dotted black line for comparison with Phase 2 observed data. Observation for study month 77 (November 2015) was identified as an outlier and excluded for this sensitivity analysis.

    (TIF)

    S2 Fig. Mean number of calls per admission by study month for the ARIMA univariate model with outlier detection enabled.

    Phase 1 observed data shown as black squares, with trend shown as the solid black line. Phase 2 observed data shown as in grey circles, with trend shown as the solid grey line. The Phase 1 trend is extended into Phase 2 as the dotted black line for comparison with Phase 2 observed data. Observation for study month 77 (November 2015) was identified as outlier and excluded for this sensitivity analysis.

    (TIF)

    S1 Data. De-identified, by-month aggregated data used in statistical analyses.

    (CSV)

    Attachment

    Submitted filename: Response to Reviewers.docx

    Attachment

    Submitted filename: Response to Reviewers Comments.docx

    Data Availability Statement

    All relevant data are within the manuscript and its Supporting Information files.


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