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. 2022 Mar 21;14(3):651. doi: 10.3390/v14030651

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison between the spike-specific IgG- and IgA-levels in serum within BNT162b2 mRNA vaccinated subjects (n = 110) and COVID-19 convalescent subjects (n = 43). Medians and interquartile ranges (IQRs) are presented for SARS-CoV-2 non-immune (NI, n = 6), vaccinated HIV-1-uninfected (HU, n = 60), vaccinated HIV-1-infected (HIV, n = 50), COVID-19 HIV-1-uninfected (COVID HU, n = 17), COVID-19 HIV-1-infected (COVID HIV, n = 26). The IgG and IgA levels are presented as antibody ratios obtained by dividing the extinction of the sample by that of the assay calibrator. The cut-off ratio for a positive IgG or IgA level at ≥1.1 is indicated by the dashed line. Significance was tested by Wilcoxon signed-rank tests. All vaccinated and COVID-19 convalescent subjects had significantly higher IgG- (p ≤ 0.0001) and IgA-levels (p ≤ 0.001) compared to the NI group (p-value not depicted in the graph). Significance was tested by Mann–Whitney U tests. **** = p ≤ 0.0001.