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Selection of gRNA for packaging versus use as mRNA for translation. Note that in the CAP3G RNA, the 5′ cap is accessible and the RNA is monomeric, while in the CAP1G form the 5′ cap is sequestered and RNA dimerizes for packaging. RNA structure schematics modeled from [28]. DIS = dimer initiation site; SD = major splice donor; PBS = primer binding site. Figure adapted from HIV Replication Cycle by BioRender.com (2022).
