Figure 4.

Role of IP6 in immature Gag lattice and in mature capsid core formation. (A) Schematic depiction of maturation of immature lattice to mature core formation, with structural model below showing position of IP6. Note that IP6 is coordinated by K359 and K290 rings in immature hexamer (left), while it interacts with R18 in the mature viral core. Figure adapted from findings of [189]. (B) Top and side views of IP6 in mature lattice, with positions of R18 residues indicated in yellow. IP6 is depicted in red. From PDB 6BHT [189]. Structures rendered by the PyMOL Molecular Graphics System, Shrodinger, LLC.