Electron microscopy and histological changes in shrimp with infectious myonecrosis virus (IMNV). (A) TEM of a purified preparation of IMNV from naturally infected Penaeus vannamei from Brazil. Photomicrographs of tissue sections from P. vannamei examined for IMNV lesions (B–D) (Scale bar = 50 μm); (B) Focal hemocytic infiltration in muscle tissue; (C) Muscle coagulation necrosis accompanied by infiltration of hemocytes; (D) Muscle liquefactive necrosis and fibrosis. ((A) Reprinted from Journal of Invertebrate Pathology, Vol. 106 (1), Lightner, D.V., Virus diseases of farmed shrimp in the Western Hemisphere (the Americas) a review, p. 21, Copyright (2011), with permission from Elsevier; (B–D) Reprinted from Aquaculture, Vol. 380, Feijó, R.G., Kamimura, M.T., Oliveira-Neto, J.M., Vila-Nova, C.M., Gomes, A.C., Maria das Graças, L.C., Maggioni, R., Infectious myonecrosis virus and white spot syndrome virus co-infection in Pacific white shrimp (Litopenaeus vannamei) farmed in Brazil, p. 5, Copyright (2013), with permission from Elsevier).