Table 2.
Association between maternal homocysteine and longitudinal first trimester embryonic CRL and EV in the included population (n = 1060), natural pregnancies (n = 555) and IVF/ICSI pregnancies (n = 505).
| Model 1 | Model 2 | |||
|---|---|---|---|---|
| CRL | ||||
| Beta (95% CI) √mm | p-value | Beta (95% CI) √mm | p-value | |
| Included population n = 919 |
−0.027 (−0.043, −0.012) | <0.001 | −0.023 (−0.038, −0.007) | 0.004 |
| Natural pregnancies n = 494 |
−0.027 (−0.052, −0.001) | 0.039 | −0.019 (−0.044, 0.006) | 0.141 |
| IVF/ICSI pregnancies, FrET n = 143 |
−0.051 (−0.080, −0.022) | <0.001 | −0.051 (−0.081, −0.023) | <0.001 |
| IVF/ICSI pregnancies, FET n = 282 |
−0.015 (−0.031, 0.001) | 0.061 | −0.013 (−0.029, 0.002) | 0.095 |
| EV | ||||
| Beta (95% CI) 3√cm | p-value | Beta (95% CI) 3√cm | p-value | |
| Included population n = 898 |
−0.013 (−0.021, −0.006) | <0.001 | −0.011 (−0.018, −0.004) | 0.003 |
| Natural pregnancies n = 482 |
−0.014 (−0.026, −0.002) | 0.022 | −0.011 (−0.022, 0.001) | 0.079 |
| IVF/ICSI pregnancies, FrET n = 144 |
−0.024 (−0.039, −0.009) | 0.001 | −0.024 (−0.039, −0.009) | 0.001 |
| IVF/ICSI pregnancies, FET n = 272 |
−0.005 (−0.013, 0.003) | 0.213 | −0.004 (−0.012, 0.003) | 0.305 |
CRL = crown-rump length, EV = embryonic volume, FET = fresh embryo transfer, FrET = frozen embryo transfer. Model 1: adjusted for GA, Model 2: adjusted for GA, conception mode (included population only), parity, smoking, folic acid supplement use, alcohol, BMI, age, and fetal sex. p-value < 0.05 represented in bold.