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. 2022 Feb 8;12(2):276. doi: 10.3390/biom12020276

Figure 17.

Figure 17

Both berberine and NAX60 can increase the effects of APR-246 on clonogenicity of PANC-28 cells in the presence WT-TP53, but in the absences of WT-TP53 they have less effects on clonogenicity. The effects of ABR-246 on clonogenicity in the presence of low doses of BBR (Panel (A)) or NAX060 (Panel (B)) were examined. PANC-28 + pLXSN in the absence of BBR or NAX060 (red bars), PANC-28 + WT-TP53 in the absence of BBR or NAX060 (blue bars), PANC-28 + pLXSN in the presence of APR-246 and 100 nM BBR (green bars), MIA-PaCa-2 + WT-TP53 in the presence of APR-246 and100 nM NAX060 (Panel (B)) (yellow bars). The colony formation abilities were repeated 3 times for each cell type and each treatment condition and similar results were observed. *** = p < 0.0001, ** p < 0.005, * p < 0.05 and NS = not statistically significant.