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. 2022 Jan 11;303(1):215–225. doi: 10.1148/radiol.211028

Figure 4:

Transarterial embolization increases the number and proportion of tumor-infiltrating lymphocytes in the intratumoral compartment of nontarget tumors. Box and whisker plots show (A) the average number of CD3+, CD8+, FOXP3+, and CD4+ cells (intrastromal and intratumoral cells) at 2 days (n = 4), 7 days (n = 6), and 12 days (n = 8) after embolization in nontarget tumors relative to control (CTRL) tumors from rats that did not undergo embolization (n = 12); (B) the average number of cells within the intratumoral compartment of nontarget tumors at 2, 7, and 12 days after embolization relative to control tumors; and (C) the average percentage of cells found within the intratumoral compartment as a function of total number of cells (intrastromal plus intratumoral cells) in nontarget tumors at 2, 7, and 12 days after embolization relative to control tumors. Whiskers indicate maximum and minimum values. Boxes extend from the 25th to 75th percentiles. The line in the middle of the box is plotted at the median. * = P < .05 and ** = P < .01 according to the generalized estimating equation model. Significant P values (left to right): in B, .02, .04; in C, .02, .03, .002, .01.

Transarterial embolization increases the number and proportion of tumor-infiltrating lymphocytes in the intratumoral compartment of nontarget tumors. Box and whisker plots show (A) the average number of CD3+, CD8+, FOXP3+, and CD4+ cells (intrastromal and intratumoral cells) at 2 days (n = 4), 7 days (n = 6), and 12 days (n = 8) after embolization in nontarget tumors relative to control (CTRL) tumors from rats that did not undergo embolization (n = 12); (B) the average number of cells within the intratumoral compartment of nontarget tumors at 2, 7, and 12 days after embolization relative to control tumors; and (C) the average percentage of cells found within the intratumoral compartment as a function of total number of cells (intrastromal plus intratumoral cells) in nontarget tumors at 2, 7, and 12 days after embolization relative to control tumors. Whiskers indicate maximum and minimum values. Boxes extend from the 25th to 75th percentiles. The line in the middle of the box is plotted at the median. * = P < .05 and ** = P < .01 according to the generalized estimating equation model. Significant P values (left to right): in B, .02, .04; in C, .02, .03, .002, .01.