Abstract
Introduction
Misclassification of spondyloarthritis (SpA) as rheumatoid arthritis (RA) may lead to delayed SpA diagnosis and suboptimal therapeutic outcomes. Here, we evaluate the literature on clinical manifestations in patients with SpA and RA, particularly seronegative RA, to understand the potential overlap, distinctions, and most reliable approaches to accurate diagnosis.
Methods
In this systematic literature review, conducted according to PRISMA guidelines, we searched key biomedical databases for English-language publications of original research articles (up to July 23, 2020) and rheumatology conference abstracts (January 1, 2018–July 31, 2020) reporting key SpA clinical presentations in patients with SpA or RA. Publications were assessed for eligibility by two independent reviewers; discrepancies were resolved by a third. Studies were evaluated for publication quality using the Downs and Black checklist.
Results
Of 4712 records retrieved, 79 met the inclusion criteria and were included in the analysis. Of these, 54 included study populations with SpA and RA, and 25 with seropositive and/or seronegative RA. Entheseal abnormalities were more frequently reported among patients with SpA than RA and with seronegative vs. seropositive RA. Psoriasis, nail psoriasis, and dactylitis were exclusively seen in SpA vs. RA. In most publications (70 of 79), advanced imaging techniques allowed for more accurate distinction between SpA and RA. Overlapping clinical characteristics occur in SpA and RA, including inflammation and destruction of joints, pain, diminished functional ability, and increased risk for comorbidities. However, of 54 studies comparing SpA and RA populations, only seven concluded that no distinction can be made based on the SpA manifestations and outcomes examined.
Conclusions
Typical SpA-related clinical symptoms and signs were observed in patients with RA, suggesting that misclassification could occur. Availability of advanced imaging modalities may allow for more prompt and comprehensive evaluation of peripheral manifestations in SpA and RA, reducing misclassification and delayed diagnosis.
Supplementary Information
The online version contains supplementary material available at 10.1007/s40744-021-00407-8.
Keywords: Axial spondyloarthritis, Psoriatic arthritis, Rheumatoid arthritis, Rheumatic diseases, Spondyloarthropathies
Plain Language Summary
Spondyloarthritis (SpA) is a group of chronic, inflammatory diseases that includes axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), in addition to other peripheral forms of SpA. AxSpA primarily affects the spine and can cause chronic back pain. PsA occurs in patients with the skin condition psoriasis and patients often experience symptoms including joint pain, stiffness, and swelling. Quick and accurate diagnosis of SpA is necessary to prevent joint damage and physical limitations. Rheumatoid arthritis (RA) is characterized by pain, swelling, and stiffness in multiple joints, and delayed diagnosis and treatment can have lasting effects. However, many patients with SpA and RA who initially seek medical care often experience delayed diagnoses. This study evaluated the literature on symptoms in patients with SpA and RA, particularly patients with RA without antibodies typically associated with the disease, to understand the potential overlap, differences, and most reliable ways to accurately diagnose patients. Data from 79 records were included in the analysis, 54 of which included study populations with SpA and RA. Skin and nail psoriasis, as well as swelling of the fingers and toes, was only seen in patients with SpA. Most studies showed that enhanced imaging allowed for distinguishing between SpA and RA. This study showed that typical signs and symptoms of SpA, including inflammation and joint pain, could also be seen in patients with RA, which suggests that challenges exist for accurately identifying SpA. This highlights the importance of advanced imaging to diagnose and treat patients with SpA in a timely manner.
Supplementary Information
The online version contains supplementary material available at 10.1007/s40744-021-00407-8.
Key Summary Points
| Misclassification of spondyloarthritis (SpA) as rheumatoid arthritis (RA) can lead to delayed diagnosis and treatment and poor outcomes for patients with SpA. |
| This study evaluated the literature for clinical manifestations of SpA and RA to understand the potential overlap, distinction, and most reliable approaches for accurate diagnosis. |
| Clinical manifestations observed exclusively in SpA included psoriasis, nail psoriasis, and dactylitis. |
| Advanced imaging techniques, such as ultrasonography and magnetic resonance imaging, provided a more accurate distinction between SpA and RA. |
| While SpA manifestations were observed among patients with RA, improvement and standardization of imaging protocols can positively impact clinical outcomes and quality of life. |
Introduction
Spondyloarthritis (SpA) refers to a group of chronic, inflammatory diseases that includes axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), as well as other peripheral types of SpA including enteropathic arthritis, reactive arthritis, and undifferentiated SpA [1, 2]. AxSpA predominantly involves inflammation of the sacroiliac joints and spine; inflammation of the spinal vertebrae, connective tissue, and joints causes chronic back pain and may eventually lead to the fusion of vertebral units [1]. AxSpA with radiographic sacroiliitis is termed radiographic axSpA, also known as ankylosing spondylitis (AS), and fulfills the definition of AS based on the 1984 modified New York criteria and the 2009 Assessment of SpondyloArthritis international Society criteria for radiographic axSpA [3]. Conversely, axSpA without radiographic sacroiliitis, which does not meet the modified New York criteria for AS, can be subclassified as nonradiographic axSpA [3]. The prevalence of axSpA ranges from 0.9 to 1.4% in the US adult population [4]. However, the true disease prevalence is not known, partly due to the significant delays in diagnosis and recognition; recent reports indicate a mean diagnostic delay of 6.7 years [5]. Challenges in distinguishing inflammatory back pain (IBP), a key symptom of axSpA that affects the spine and sacroiliac joints, from other forms of low back pain in the general population are a primary contributor to delay or lack of diagnosis, especially among patients without definitive radiographic sacroiliitis [4]. AxSpA is associated with substantial physical, economic, and emotional liabilities [4].
PsA has a prevalence of approximately 100–200 per 100,000 in the general adult population and an incidence rate of 3.6–7.2 per 100,000 patient-years [6]. PsA manifests with axial disease, peripheral joint inflammation, enthesitis, dactylitis, and skin and nail psoriasis, either alone or in combination [7]. A PsA diagnosis delayed by as few as 6 months may be associated with worse peripheral joint erosions, progressive joint damage, and substantial physical limitations [7].
Rheumatoid arthritis (RA), with an estimated global age-standardized point prevalence and annual incidence rate of 246.6 and 14.9 per 100,000 population, respectively, is characterized by pain, swelling, and stiffness in multiple joints [8]. Disability is common and substantial; in a large US study, 35% of patients with RA had employment-related disability after 10 years [9]. Prompt diagnosis and treatment are associated with improved clinical and radiographic outcomes, as well as the probability of remission; diagnosis delays beyond 3 months may be detrimental [10].
Infiltration of the joint synovia with inflammatory cells and cellular mediators (cytokines) is the hallmark of arthritis in both RA and SpA [11]. Resultant lytic destruction of bone and cartilage follows in both RA and SpA; in SpA, there are also areas of bony proliferation and ankylosis [12]. Inflammation of ligament and tendon insertions into bone (enthesitis) and bone itself (osteitis) are also characteristic pathologies of SpA [1, 2]. However, several key factors distinguish SpA from other types of arthritis, including the distribution and type of musculoskeletal manifestations and particular extra-articular features, as well as genetic associations and structural outcome [12]. Joint damage in RA comprises widespread destruction with minimal or no indications of repair; in AS, damage to the spine or joint is usually accompanied by remodeling [12]. The pathophysiology of chronic inflammatory diseases is rooted in the interaction network of proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1, IL-6, IL-17, and IL-23 [13]. For many patients with inflammatory conditions such as RA and SpA, their response to inhibitors of these inflammatory cytokines may differ, suggesting a disease-dependent, hierarchical cytokine effect [13]. Ongoing studies implicate TNF-α, IL-1, and IL-6 in RA pathology and TNF-α, IL-17, and IL-23 in SpA [13]. Thus, correct diagnosis is important when steering the patient toward appropriate therapies.
As many patients with axSpA, PsA, and RA initially seek medical care from primary care physicians or other nonrheumatology healthcare providers, correct and prompt diagnosis is variable and often delayed. Numerous recommendations and guidelines exist to promote early rheumatology referrals [14–16]. Early diagnosis and treatment before irreversible changes occur are crucial for optimal disease management and improved patient quality of life. Diagnostic algorithms for axSpA [1], PsA [17], and RA [18] are available as a guide for rheumatologists in their clinical assessments. Overall, diagnosis relies on clinical judgement of features that are characteristic of each disease spectrum, including the patient’s history of symptoms and manifestations, physical findings, laboratory workup, and imaging information. However, overlap in clinical manifestations of inflammatory rheumatic diseases, particularly early in the disease course, may lead to misdiagnosis. Thorough evaluation of disease presentations is crucial to guide decisions pertaining to treatment and patient care. This systematic review assesses the available evidence on overlapping clinical manifestations associated with axSpA, PsA, and RA to better understand whether disease misclassification, and therefore delayed diagnosis, may occur.
Methods
Data Sources
This systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [19]. We searched the MEDLINE Literature Analysis and Retrieval System Online (including MEDLINE In-Process), Excerpta Medica (Embase), BIOSIS Previews, and Evidence-Based Medicine Reviews databases for original research articles (up to July 23, 2020) reporting studies on clinical manifestations of SpA and RA. The list of search terms is provided in Table S1. Additionally, abstract archives of the American College of Rheumatology/Association of Rheumatology Health Professionals Annual Meeting and the European League Against Rheumatism Annual European Congress of Rheumatology were searched (January 1, 2018–July 31, 2020) to identify abstracts not yet indexed in the aforementioned biomedical databases at the time of the search. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.
Eligibility Criteria and Article Selection
Eligible records for inclusion were English-language, noninterventional, original research studies of adult patients that either included both RA and SpA or seropositive and/or seronegative RA as major populations and that also reported SpA-related clinical manifestations. The key inclusion and exclusion criteria are described in Table 1. Abstracts of all records retrieved from the literature search were screened for eligibility by two independent reviewers; discrepancies were reconciled by a third.
Table 1.
Details of systematic literature review methodology
| Databases |
Electronic databases: MEDLINE, MEDLINE In-Process, Embase, BIOSIS Previews, and Evidence-Based Medicine Reviews Conference databases: ACR/ARHP Annual Meeting and EULAR Annual European Congress of Rheumatology archives |
| Time frame |
Full text articles: up to July 23, 2020 Conference abstracts: January 1, 2018–July 31, 2020 |
| Inclusion criteria |
Population: studies including adult patients with either both RA and SpA or seropositive and/or seronegative RA Outcomes: SpA-related clinical manifestations (documented history and current manifestations): – Sacroiliitis on imaging – Active (acute) inflammation on MRI suggestive of sacroiliitis – Oligoarthritis – Polyarthritis – Definitive radiographic sacroiliitis – IBP – Peripheral arthritis – Enthesitis – Uveitis – Dactylitis – Psoriasis – Nail disease (psoriatic nail disease or nail psoriasis) – IBD, specifically Crohn’s disease and ulcerative colitis – Good response to NSAIDs – HLA-B27 – Elevated CRP – Structural damage, hip involvement, spinal deformities Study design: nonrandomized controlled trials, including prospective and retrospective observational, case control, prospective and retrospective longitudinal, and cross-sectional studies |
| Exclusion criteria |
Non-English-language articles Interventional studies focusing on the evaluation of clinical efficacy and/or safety, including RCTs, nRCTs, or single-arm trials Reviews, editorials, case reports, case series, commentaries, animal and in vitro studies, and studies focusing on clinical efficacy and safety of an intervention Publications not relevant to the study objective |
| Critical appraisal tools | Downs and Black Quality Index for assessing risk of bias [20] |
| Data extraction | Total number of patients analyzed, number of patients with outcome, mean, SD, SE, median, range, 95% CI, and P values, as applicable |
ACR American College of Rheumatology, ARHP Association of Rheumatology Health Professionals, CRP C-reactive protein, EULAR European League Against Rheumatism, IBD inflammatory bowel disease, IBP inflammatory back pain, MRI magnetic resonance imaging, nRCT nonrandomized controlled trial, NSAID nonsteroidal anti-inflammatory drug, RA rheumatoid arthritis, RCT randomized controlled trial, SpA spondyloarthritis
Data Extraction and Quality Assessment
Data from the final list of included publications were extracted by one reviewer and validated by a second independent reviewer; any discrepancies were resolved by a third reviewer. For each record, the study title, year of publication, study design, total study population, objective, inclusion/exclusion criteria, baseline patient data, outcomes assessed, and authors’ conclusions were extracted. Baseline patient data collected included age, sex, geographic region, race/ethnicity, proportion of patients with rheumatoid factor (RF) and anticyclic citrullinated peptide (anti-CCP) expression, and disease and symptom duration. Outcomes extracted comprised current and historical SpA-related clinical manifestations, imaging, laboratory tests, and disease activity measures. Clinical manifestation outcomes included oligoarthritis, polyarthritis, IBP, peripheral arthritis, enthesitis, uveitis, dactylitis, psoriasis, nail disease (psoriatic nail psoriasis or nail psoriasis), inflammatory bowel disease (specifically Crohn’s disease and ulcerative colitis), and good response to nonsteroidal anti-inflammatory drugs. Imaging outcomes consisted of sacroiliitis on imaging, active (acute) inflammation on magnetic resonance imaging (MRI) suggestive of sacroiliitis, definitive radiographic sacroiliitis, structural damage, hip involvement, and spinal deformities. Laboratory tests comprised HLA-B27 expression and elevated C-reactive protein (CRP) levels. Subjective measures of disease activity included physician global assessment (PGA); patient-reported outcome (PRO) measures were pain and fatigue on a visual analog scale such as patient global assessment (PtGA) of disease activity.
The procedural quality of each publication was evaluated using the Downs and Black Quality Index for evaluating risk of bias [20]. Briefly, study methodology was assessed using 26 questions examining the characteristics of study reporting, external validity, and internal validity (bias and confounding) (Table S2). The total possible score on the Downs and Black scale was 27, with higher numbers indicating higher methodological quality or lower risk of bias.
Results
Study Selection, Characteristics, and Quality Assessment
The initial search yielded 4712 records, from which 79 unique studies were identified for inclusion after screening (Fig. 1) [21–99]. Of these, 54 included study populations with RA and SpA [21–74], and 25 included study populations with seropositive and/or seronegative RA [75–99]. SpA-related outcomes or manifestations reported in included studies assessed by clinical examination and/or imaging comprised peripheral arthritis [21–28, 30–36, 38–42, 45–52, 57–63, 66, 68, 71, 72, 74–99], polyarthritis [22, 33, 36, 78, 79], and oligoarthritis [22, 33], enthesitis or enthesopathy [22–29, 31–33, 36, 44, 45, 47–49, 54–56, 60, 63, 66, 67, 69, 71, 72, 75, 84], psoriasis [21–23, 25, 26, 30, 59, 70, 74], dactylitis [21, 27, 33, 36, 46, 55, 71–73], nail psoriasis [21, 23, 28, 54, 59, 72], axial disease (IBP [25, 26, 32, 33, 38, 48, 55, 61–63, 69], spinal deformities [33, 37, 38, 43, 51, 64, 90], hip involvement or damage [35, 47, 64, 90], and sacroiliitis [43, 55, 90]), extra-articular manifestations (uveitis [53, 55, 70] and inflammatory bowel disease [70, 74]), and laboratory measures (HLA-B27 positivity [24–26, 53, 55, 65, 69, 78] and elevated CRP levels [21, 34, 46, 47, 49, 65, 76, 89, 99]). Other data reported included PROs (pain [30, 34, 38, 40, 46, 57, 61, 76, 98], fatigue [30, 38, 98], and PtGA of disease activity [30, 34, 38, 61, 62, 77, 81, 98]), and PGA of disease [30, 38, 62, 77, 81]. Imaging methods used across included studies comprise ultrasonography [21–23, 25, 26, 28, 29, 31, 32, 34, 39, 44, 47, 48, 50, 54–56, 59, 66, 67, 69, 71, 72, 74, 75, 82, 84, 85], classic radiography (i.e., X-ray) [29, 33, 36, 40, 45, 46, 51, 56, 68, 75–80, 83, 86, 89, 93, 95, 99], computed tomography [43], and MRI [24, 27, 37, 41, 47, 49, 57, 60].
Fig. 1.
PRISMA diagram for article selection. PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses, SLR systematic literature review
Study characteristics are described in Table 2. The 79 included analyses, published between 1997 and 2020, were conducted in Europe (n = 47), North America (n = 11), Asia (n = 8), Africa (n = 4), South America (n = 1), and combined populations across multiple geographical regions, including Europe, Asia, North America, North Africa, and Oceania (n = 8). Of those studies reporting information on study design and setting, most were prospective cohort (n = 41) or cross-sectional (n = 21) studies in single (n = 31) or multicenter (n = 19) settings, comprising a study population of 35–117,794 patients with SpA and RA. Across all studies, the proportion of men with SpA and RA (both seropositive and seronegative) ranged from 17.4 to 87.5% and from 6.7 to 68.2%, respectively. Included patients with SpA and RA (both seropositive and seronegative) had a mean age of 30.9–54.5 years and 41.6–67.3 years, respectively, and a mean disease duration of 8.0–1083.6 months and 2.5–192.0 months, respectively.
Table 2.
Characteristics of articles reporting SpA manifestations among patients with SpA and RA
| Study | Study design | Country | Study population, N | Male, % | Primary SpA manifestation(s) | Examination site(s) | Primary examination method(s) |
|---|---|---|---|---|---|---|---|
| Tinazzi et al. [21] | Prospective cohort | Italy | 96 |
RA, 26 PsA, 59 |
Enthesitis, dactylitis | Hand | Ultrasonography |
| Zabotti et al. [22] | Prospective cohort | Italy | 60 |
RA, 21 PsA, 42 |
Peripheral arthritis, enthesitis | Hand | Ultrasonography |
| Zabotti et al. [23] | Cross-sectional | Italy | 73 |
S+ RA, 48 S− RA, 13 PsA, 56 |
Enthesitis, psoriasis/nail psoriasis | Hand | Ultrasonography, integrated rheumatology/ dermatology evaluation |
| Narváez et al. [24] | Prospective cohort | Spain | 37 |
RA, 20 PsA, 35 |
Enthesitis | Wrist, hand | MRI |
| Ottaviani et al. [25] | Case control | France | 114 |
RA, 26 PsA, 22 |
Peripheral arthritis | Shoulder | Ultrasonography |
| Ebstein et al. [26] | Cross-sectional | France | 97 |
RA, 17 SpA, 68 |
Enthesitis | Foot, elbow, knee | Ultrasonography |
| Mathew et al. [27] | Prospective cohort | India | 36 |
RA, 22 PsA, 44 |
Peripheral arthritis, enthesitis | Hand | MRI |
| Fournié et al. [28] | Prospective cohort | France | 41 |
RA, 24 PsA, 55 |
Peripheral arthritis, enthesitis | Finger | Ultrasonography |
| Falsetti et al. [29] | Prospective cohort | Italy | 598 |
RA, 30 PsA, 48 |
Enthesitis | Heel | Ultrasonography |
| Ogdie et al. [30] | Retrospective cohort | United States | 4827 |
S+ RA, 24 S− RA, 23 PsA, 46 AxSpA, 61 |
Peripheral arthritis, other | NR | NR |
| Erturk et al. [31] | Cross-sectional | Turkey | 93 |
S+ RA, 8 S− RA, 11 AxSpA, 17 |
Enthesitis | Hand | Ultrasonography |
| Genc et al. [32] | Prospective cohort | Turkey | 62 |
RA, 8 AxSpA, 78 |
Enthesitis | Shoulder, knee, heel, foot | Ultrasonography |
| Helliwell et al. [33] | Prospective cohort | Australia, Belgium, Canada, France, Ireland, Morocco, New Zealand, South Africa, Italy, Spain, Sweden, United Kingdom, United States | 1124 |
RA, 29 PsA, 52 |
Peripheral arthritis, enthesitis, dactylitis, spinal deformities | Heel, knee, hand, finger | Radiography |
| Sakellariou et al. [34] | Cross-sectional | Italy | 156 |
RA, 28 PsA, 32 |
Peripheral arthritis | Wrist, hand, foot | Ultrasonography, radiography |
| Low et al. [35] | Prospective cohort | Ireland | 58 |
S+ RA, 44 S− RA, 30 PsA, 25 |
Other | Hip, waist | Synovial biopsy by needle arthroscopy |
| Inanc et al. [36] | Prospective cohort | Turkey | 303 |
RA, 17 PsA, 36 |
Peripheral arthritis | Hand, foot | Radiography |
| Baraliakos et al. [37] | Prospective cohort | Germany | 40 |
RA, 12 AxSpA, 50 |
Spinal deformities | Cervical spine | MRI |
| Michelsen et al. [38] | Cross-sectional | Norway | 1791 |
RA, 32 PsA, 51 AxSpA, 67 |
Peripheral arthritis, IBP, spinal deformities, other | NR | NR |
| Ceccarelli et al. [39] | Cross-sectional | Italy | 113 |
RA, 16 PsA, 47 |
Peripheral arthritis | Wrist, knee | Ultrasonography |
| Reddy et al. [40] | Prospective cohort | United States | 19,588 |
RA, 25 PsA, 48 |
Peripheral arthritis, other | Spine, neck | Radiography |
| Cimmino et al. [41] | Prospective cohort | Italy | 102 |
RA, 14 PsA, 47 |
Peripheral arthritis | Wrist, hand | MRI |
| Liphardt et al. [42] | Prospective cohort | Germany | 298 |
RA, 29 PsA, 41 |
Peripheral arthritis | Hand | Hand dynamometer |
| Fauny et al. [43] | Retrospective cohort | France | 244 |
RA, 22 AxSpA, 87 |
Spinal deformities | Vertebra | Computed tomography |
| Batticciotto et al. [44] | Retrospective cohort | Italy | 35 |
RA, 15 SpA, 40 |
Enthesitis | Wrist, hand | Ultrasonography |
| Ichikawa et al. [45] | Prospective cohort | Japan | 220 |
S+ RA, 51 S− RA, 30 PsA, 57 |
Peripheral arthritis, enthesitis | Hand, foot | Radiography |
| Lindqvist et al. [46] | Prospective cohort | Sweden | 1036 |
RA, 30 PsA, 42 AxSpA, 71 |
Peripheral arthritis, other | NR | Radiography |
| Ramírez et al. [47] | Cross-sectional | Spain | 107 | NR | Peripheral arthritis, enthesitis, hip damage or involvement | Hip | Ultrasonography, radiography |
| Harman et al. [48] | Prospective cohort | Turkey | 142 |
RA, 15 AxSpA, 60 pSpA, 62 |
Peripheral arthritis, enthesitis | Shoulder, elbow, wrist, hand, knee | Ultrasonography |
| Abrar et al. [49] | Prospective cohort | Germany | 53 |
RA, 55 PsA, 53 |
Enthesitis | Hand | MRI |
| Figus et al. [50] | Cross-sectional | Italy, Croatia, Bulgaria | 106 | NR | Peripheral arthritis | Wrist | Ultrasonography |
| Murphy et al. [51] | Prospective cohort | Ireland | 38 |
RA, 40 SpA 61 |
Peripheral arthritis | Hand, foot | Radiography |
| Kruithof et al. [52] | Prospective cohort | Belgium | 142 |
RA, 48 PsA, 64 SpA, 79 |
Peripheral arthritis | Knee | Synovial biopsy by needle arthroscopy |
| Noche et al. [53] | Cross-sectional | Cameroon | 24 |
RA, 19 AxSpA, 88 |
Ophthalmic manifestations | Eye | Routine ophthalmic examination |
| Idolazzi et al. [54] | Cross-sectional | Italy | 88 |
RA, 27 PsA, 51 |
Enthesitis, psoriasis/nail psoriasis | Nails | Ultrasonography |
| D’Agostino et al. [55] | Cross-sectional | France | 194 | NR | Enthesitis | Pelvis, knee, foot | Ultrasonography |
| Falsetti et al. [56] | Retrospective cohort | Italy | 200 | NR | Enthesitis | Shoulder | Ultrasonography, radiography |
| Cimmino et al. [57] | Prospective cohort | Italy | 17 |
RA, 20 PsA, 29 |
Peripheral arthritis | Wrist, hand | MRI |
| Roman-Ivorra et al. [58] | Cross-sectional | Spain | 197 |
RA, 18 PsA, 18 |
Peripheral arthritis, other | Hand | Hand dynamometer |
| Sandobal et al. [59] | Prospective cohort | Argentina | 62 | NR | Peripheral arthritis, psoriasis/nail psoriasis | Nails | Ultrasonography |
| Schoellnast et al. [60] | Retrospective cohort | Austria | 39 |
RA, 19 PsA, 33 |
Peripheral arthritis, enthesitis | Wrist, hand | MRI |
| Bailly et al. [61] | Prospective cohort | France | 165 |
RA, 19 AxSpA, 56 |
Other | NR | NR |
| Cemeroğlu et al. [62] | Retrospective cohort | Turkey | 90 |
RA, 22 AxSpA, 69 |
Other | NR | NR |
| Leeb et al. [63] | Cross-sectional | Austria | 255 |
RA, 68 PsA, 68 |
Peripheral arthritis, other | NR | NR |
| Harter et al. [64] | Retrospective cohort | United Kingdom | 49,094 | NR | Hip damage or involvement | Fractures of the hip and vertebra | NR |
| Illeez et al. [65] | Retrospective cohort | Turkey | 321 |
RA, 18 AS, 69 |
– | Blood | Immunoassays |
| Ahmed et al. [66] | Prospective cohort | Egypt | 35 | NR | Peripheral arthritis, enthesitis | Wrist, hand | Ultrasonography |
| Ward et al. [67] | Prospective cohort | United States | 41 |
RA, 24 SpA, 55 |
Enthesopathy | Ankle | Ultrasonography |
| Helenius et al. [68] | Case control | Finland | 64 |
RA, 8 AxSpA, 68 SpA, 57 |
– | Jaw | Stomatognathic examination, radiography |
| Milutinovic et al. [69] | Prospective cohort | Serbia | 102 |
RA, 23 AxSpA, 77 SpA, 64 |
Enthesitis | NR | Ultrasonography |
| Aletaha et al. [70] | Case control | United States | 117,794 | NR | – | NR | NR |
| Smerilli et al. [71] | Cross-sectional | Italy | 60 |
RA, 23 PsA, 53 |
Enthesitis | Hand | Ultrasonography |
| Tinazzi et al. [72] | Prospective cohort | Italy | 82 |
RA, 29 PsA, 41 |
Enthesitis | Hand | Ultrasonography |
| Rothschild et al. [73] | Prospective cohort | United States | 246 | NR | Dactylitis | NR | NR |
| Matschke et al. [74] | Cross-sectional | United Kingdom | 30 |
RA, 28 AS, 67 |
– | Knee | Ultrasonography |
| Grosse et al. [75] | Prospective cohort | France | 108 |
CCP+, 72 CCP−, 28 |
RA serostatus comparison | Wrist, hand | Ultrasonography, radiography |
| Mouterde et al. [76] | Prospective cohort | France | 748 |
S+ RA, 23 S− RA, 23 |
RA serostatus comparison | Wrist, hand, foot | Radiography |
| Slimani et al. [77] | Cross-sectional | Algeria | 249 |
S+ RA, 14 S− RA, 16 |
RA serostatus comparison | Hand, foot | Radiography |
| Liu et al. [78] | Retrospective cohort | United States | 80 |
S+ RA, 50 S− RA, 50 |
RA serostatus comparison | Hand | Radiography |
| Oprea et al. [79] | Prospective cohort | Romania | 66 |
S+ RA, 7 S− RA, 19 |
RA serostatus comparison | Hand | Radiography |
| Barra et al. [80] | Prospective cohort | Canada | 841 |
S+ RA, 23 S− RA, 31 |
RA serostatus comparison | Hand, foot | Radiography |
| Deveci et al. [81] | Cross-sectional | Turkey | 48 |
S+ RA, 15 S− RA, 13 |
RA serostatus comparison | Blood | Immunoassays |
| Hamdi et al. [82] | Cross-sectional | Tunisia | 118 | NR | RA serostatus comparison | Wrist, hand | Ultrasonography |
| Asikainen et al. [83] | Prospective cohort | Finland, Sweden | 312 | NR | RA serostatus comparison | Hand, foot | Radiography |
| Azuaga-Piñango et al. [84] | Retrospective cohort | Spain | 145 | NR | RA serostatus comparison | Wrist, hand | Ultrasonography |
| Azuaga-Piñango et al. [85] | Prospective cohort | Spain | 205 | NR | RA serostatus comparison | Wrist, hand | Synovial biopsies using arthroscopy, ultrasonography |
| Rauwel et al. [86] | Prospective cohort | France | 487 |
S+ RA, 20 S− RA, 26 |
RA serostatus comparison | Hand, foot | Radiography |
| Hermosillo [87] | Prospective cohort | Mexico | 64 | NR | RA serostatus comparison | NR | NR |
| Morales-Arango et al. [88] | Prospective cohort | Mexico | 28 | Total, 22 | RA serostatus comparison | NR | NR |
| Shin et al. [89] | Retrospective cohort | South Korea | 109 |
S+ RA, 19 S− RA, 13 |
RA serostatus comparison | Hand, foot | Radiography |
| Sahatçiu-Meka et al. [90] | Prospective cohort | Kosovo | 250 |
S+ RA, 26 S− RA, 26 |
RA serostatus comparison | Hand, foot, shoulder, knee, elbow, hip, spine | Clinical assessment |
| Sahatçiu-Meka et al. [91] | Retrospective cohort | Kosovo | 250 |
S+ RA, 27 S− RA, 27 |
RA serostatus comparison | Hand | NR |
| Rajapaksa et al. [92] | Case control | Sri Lanka | 162 |
S+ RA, 16 S− RA, 13 |
RA serostatus comparison | NR | Immunoassays |
| Shin et al. [93] | Prospective cohort | South Korea | 1198 | NR | RA serostatus comparison | Hand, foot | Radiography |
| Modi et al. [94] | Cross-sectional | United States | 884 | NR | RA serostatus comparison | NR | NR |
| Shankar et al. [95] | Cross-sectional | India | 211 | Total, 12 | RA serostatus comparison | Hand | Radiography |
| Fujinami et al. [96] | Prospective cohort | Japan | 30 | NR | RA serostatus comparison | Blood | Immunoassays |
| Othman et al. [97] | Retrospective cohort | Malaysia | 80 |
S+ RA, 17 S− RA, 18 |
RA serostatus comparison | Ankle, elbow, knee, shoulder, hand, wrist | Immunoassays |
| Cappelli et al. [98] | Cross-sectional | United States | 165 | Total, 18 | RA serostatus comparison | NR | PROs |
| Choi et al. [99] | Prospective cohort | Belgium | 241 |
S+ RA, 26 S− RA, 33 |
RA serostatus comparison | NR | Radiography |
AS ankylosing spondylitis, axSpA axial spondyloarthritis, CCP cyclic citrullinated peptide, IBP inflammatory back pain, MRI magnetic resonance imaging, NR not reported, PRO patient-reported outcome, PsA psoriatic arthritis, pSpA peripheral spondyloarthritis, RA rheumatoid arthritis, S+ RA seropositive RA, S− RA seronegative RA, SpA spondyloarthritis
The methodological quality of each study included in the analysis is described in Table S3; the overall scores on the quality index ranged from 9 to 15 (index range 0–27). For questions assessing study reporting, scores ranged from 5 to 8 (index range 0–11), with most studies (n = 59) having a score ≥ 7. For questions assessing external validity, scores ranged from 0 to 2 (index range 0–3); most records had a score of 0. For questions assessing internal validity (bias), scores ranged from 2 to 5 (index range 0–7), with 53 studies having a score of 4. Lastly, for questions assessing internal validity (confounding–selection bias), scores ranged from 1 to 3 (index range 0–6), with most studies (n = 73) having a score of 1. For questions relating to internal and external validity, “unable to determine” and “no” responses were both scored as 0, which lowered the overall validity scores of included studies. Notably, some of the questions in the Downs and Black checklist are relevant only to interventional studies, which were excluded from this review; therefore, this may have contributed to lower checklist scores for studies included in this review.
Clinical Manifestations and Outcomes in SpA vs. RA
Peripheral Arthritis
Overall, 65 studies reported data on peripheral arthritis (Fig. 2). Key outcomes included findings from both clinical examination (Clinical Disease Activity Index, Disease Activity Score in 28 joints [DAS28], swollen joint count, tender joint count, morning stiffness, grip strength, and synovial biopsy by needle arthroscopy) and imaging (synovitis by imaging, joint effusion, joint space narrowing, periostitis, erosion, periosteal inflammation on MRI, bursitis, joint osteolysis, juxta-articular new bone formation, and bone cyst formation). A total of 26 studies evaluated peripheral arthritis as a primary focus of their study, making comparisons among patients with SpA and RA; of these, only two concluded that there were no differences between SpA and RA based on MRI [41] and ultrasonographic and MRI [47] findings (Table 3). In general, the frequency of presence or absence of peripheral arthritis was relatively equal among patients with SpA and RA. However, several studies noted specific anatomical sites that were more prominently affected by SpA than RA. Ottaviani and colleagues reported ultrasound findings indicating that patients with SpA had a higher frequency of acromioclavicular joint synovitis than those with RA, as well as lower occurrence of subacromial and subdeltoid bursitis, glenohumeral effusion, and humeral bone erosion [25]. Office extremity MRI revealed that periosteal inflammation at the first interphalangeal joint was exclusively present among patients with PsA vs. RA, whereas synovitis in the metacarpophalangeal (MCP) joint was observed more frequently among patients with RA vs. PsA [27]. At baseline, tibiotalar joint synovitis was observed significantly more frequently in patients with SpA and gout by ultrasound vs. those with RA and reactive arthritis; after 1 year, tibiotalar joint synovitis was observed more frequently in the RA group than in the SpA, gout, and reactive arthritis groups [48]. Subtalar and talonavicular joint synovitis were observed more frequently in the early RA group than in the SpA, gout, and reactive arthritis groups [48]. Ultrasound findings of synovitis and erosions at the distal interphalangeal joints were exclusively observed in PsA vs. RA, and joint effusion was frequently seen at radiocarpal and midcarpal joints in RA vs. PsA [66]. Effusion at the third proximal interphalangeal (PIP) joint was detected more significantly in PsA than RA [66]. A registry analysis revealed similarities with regard to swollen joint count and tender joint count among patients with seronegative RA and SpA [30]. Of note, Figus and colleagues highlighted that although clinical examinations showed no differences between RA and PsA, ultrasound studies detected significant score differences in joint effusion, synovial hypertrophy, Doppler signal, II MCF, and wrist between oligoarticular PsA and RA, but no differences were observed between polyarticular PsA and RA [50].
Fig. 2.
Summary of the number of studies reporting SpA clinical manifestations and the authors’ conclusions regarding the feasibility of distinguishing between SpA and RA populations. IBP inflammatory back pain, PRO patient-reported outcome, RA rheumatoid arthritis, SpA spondyloarthritis
Table 3.
Summary of SpA manifestations among patients with SpA and RA, and authors’ conclusions regarding the feasibility of differentiating the two diseases
| Study | Primary manifestation outcome(s) | Sub-outcome(s) | Results | Can SpA and RA be differentiated? |
|---|---|---|---|---|
| Tinazzi et al. [21] | Enthesitis | Flexor tenosynovitis | Of 1732 measurements performed in 864 pulleys, patients with PsA had significantly thicker pulleys in every digit vs. those with RA | Yes |
| Dactylitis | – |
Among patients with PsA with or without a history of dactylitis, only the second-digit A1 pulley was thicker in patients with previous dactylitis The mean thickness of PsA pulleys remained significantly higher than those of RA when patients with PsA with previous dactylitis were excluded, except for the A1 pulley of the second finger |
||
| Zabotti et al. [22] | Peripheral arthritis | Synovitis | Joint synovitis was more frequently detected in early RA than early PsA (91.1 vs. 59.6%, respectively; P = 0.0001) | Yes |
| Enthesitis | Flexor tenosynovitis, soft tissue edema |
At the MCP joint, inflammation of the peritendon extensor digitorum tendon was seen in 2.5% of the joints in early RA vs. 54.1% of the joints in early PsA (P = 0.0001) At the PIP joint, central slip enthesitis was exclusively observed in early PsA (P = 0.0045) Soft tissue edema was detected almost exclusively in fingers of patients with PsA (P = 0.0002) |
||
| Zabotti et al. [23] | Enthesitis | Peritendon inflammation | Ultrasound studies revealed peritendon inflammation of the extensor digitorum tendon exclusively among patients with PsA vs. S− RA (P = 0.006) | Yes |
| Psoriasis, nail psoriasis | – |
Of patients initially diagnosed with early S– RA, 25% were reclassified as early PsA after presenting with cutaneous or nail psoriasis upon further rheumatology-dermatology evaluation Integrated ultrasonography and dermoscopy improved the recognition of subclinical psoriatic findings; the specificity for PsA diagnosis from 83.3% (dermoscopy alone) and 88.1% (ultrasound alone) to 90.5% |
||
| Narváez et al. [24] | Enthesitis | Bone marrow edema, tenosynovitis |
MRI findings of enthesitis and extensive diaphyseal bone marrow edema were seen exclusively in early PsA (12/17 patients; 71%) vs. early RA (P = 0.0001) Both diffuse and pronounced soft tissue edema spreading to the subcutis were observed more frequently among patients with early PsA vs. early RA (P = 0.002) No significant differences were noted in the frequency of synovitis, bone erosions, subchondral bone edema, or tenosynovitis between the two groups The extensor tendons were more frequently involved in RA, and the flexor tendons were more frequently involved in PsA (P = 0.014) |
Yes |
| Psoriasis | – | 1 patient initially presented with S– oligoarthritis, but a diagnosis of PsA was suspected because of a family history of psoriasis; this patient was then diagnosed with PsA months after the MRI with the presentation of skin lesions | ||
| Ottaviani et al. [25] | Peripheral arthritis | Synovitis, bursitis, joint effusion, bone erosion | In ultrasound studies, patients with SpA had a higher frequency of acromioclavicular joint synovitis vs. those with RA (66 vs. 5%; P < 0.0001), and lower occurrence of subacromial and subdeltoid bursitis (39 vs. 67%; P = 0.015), glenohumeral effusion (5 vs. 28%; P = 0.008), and humeral bone erosion (10 vs. 56%; P < 0.0001) | Yes |
| Ebstein et al. [26] | Enthesitis | Enthesophytes |
The mean (SD) MASEI score was 8.5 (7.3) for patients with RA and 7.8 (6.5) for those with SpA The mean (SD) GUESS score was 5.8 (3.1) for RA and 6.3 (3.9) for SpA |
No |
| Mathew et al. [27] | Peripheral arthritis | Periosteal inflammation at MCP and PIP joints, synovitis |
Office extremity MRI revealed that periosteal inflammation at the first interphalangeal joint was exclusively present among patients with PsA vs. RA Synovitis in the MCP joint was observed more frequently among patients with RA than those with PsA (P = 0.008) |
Yes |
| Enthesitis | Flexor tenosynovitis, bone marrow edema | Diaphyseal bone marrow edema (P = 0.004) and flexor tenosynovitis (P = 0.008) were detected more frequently in patients with PsA vs. RA | ||
| Fournié et al. [28] | Peripheral arthritis | Synovitis, joint erosion |
Synovitis was observed by ultrasound in all fingers with RA (25/25; 100%) vs. 76% of fingers with PsA (19/25 fingers) Joint erosions were observed in 19 of 25 fingers with RA (76%) by ultrasound vs. 52% of fingers with PsA (13/25 fingers) |
Yes |
| Enthesitis | Tenosynovitis, enthesophytes |
Extrasynovial changes indicative of enthesitis were observed by ultrasound imaging in 84% of fingers with PsA vs. none with RA Pseudotenosynovitis, characterized by diffuse inflammation of digital soft tissues, was also observed in 4 fingers with PsA; this may play a role in the development of dactylitis |
||
| Falsetti et al. [29] | Enthesitis | Enthesophytes | Ultrasonography studies revealed a significantly lower prevalence of posteroinferior calcaneal enthesophytosis in RA vs. PsA (P < 0.05) | Yes |
| Ogdie et al. [30] | Peripheral arthritis | CDAI, SJC, TJC | Patients with SpA (PsA and axSpA) had significantly lower TJC vs. those with RA; patients with SpA and S− RA had significantly lower SJC vs. those with S+ RA | Yes |
| Other | PGA, PtGA, pain and fatigue VAS |
Patients with S+ RA had a higher mean PGA score vs. those with S− RA or PsA, but a lower score than those with axSpA Patients with S+ RA had a mean PtGA score comparable with that of patients with S− RA but lower than those with PsA or axSpA |
||
| Erturk et al. [31] | Enthesitis | Erosion and calcification at tendons |
Hypoechogenicity of quadriceps tendon (P = 0.037), bone erosion at the quadriceps tendon attachment (P = 0.003), and calcification at the Achilles’ tendon (P = 0.023) were observed more frequently in patients with S– than those with S+ RA More patients with AS had bone erosion at the common extensor tendon (P < 0.001), calcification at the Achilles’ tendon (P = 0.024), and erosion at the triceps tendon (P = 0.035) than those with S– RA |
Yes |
| Genc et al. [32] | Enthesitis | Enthesophytes |
Authors did not find any difference in the frequency of tendon involvement and entheseal abnormalities among patients with RA and AS by ultrasound The most frequently affected entheseal sites in the lower limbs were the suprapatellar, infrapatellar, and Achilles’ tendon in both groups |
No |
| Helliwell et al. [33] | Peripheral arthritis | Joint osteolysis, juxta-articular new bone formation | Juxta-articular new bone formation and osteolysis were observed more frequently via radiography among patients with SpA (polyarticular and nonpolyarticular PsA) vs. RA | Yes |
| Enthesitis | Entheseal erosion | Entheseal erosion and new bone formation were observed more frequently via radiography among patients with polyarticular PsA vs. polyarticular RA | ||
| Dactylitis | – | Significantly more patients with polyarticular PsA had dactylitis vs. those with RA (P < 0.001) | ||
| Spinal deformities | Spinal pain and stiffness | Spinal pain and stiffness were observed more frequently among patients with polyarticular PsA vs. RA | ||
| Sakellariou et al. [34] | Peripheral arthritis | Synovitis | Serum calprotectin significantly correlated with ultrasonographic synovitis in early onset, untreated PsA vs. RA | Yes |
| Low et al. [35] | Other | Body composition |
Patients with S− RA had significantly increased BMI (P = 0.033) and waist circumference (P = 0.017), but not hip circumference (P = 0.248) vs. those with S+ RA Patients with PsA had significantly increased BMI (P < 0.001), waist circumference (P = 0.001), and hip circumference (P < 0.001) vs. those with S+ RA but not S− RA There was a significant correlation between waist circumference and both synovitis (r = 0.31, P = 0.018) and vascularity (r = 0.34, P = 0.010) at arthroscopy |
Yes |
| Inanc et al. [36] | Peripheral arthritis | Erosive disease |
In this study, 16 of 79 RF– patients with RA (20%), 104 of 129 RF+ patients with RA (81%), and 7 of 56 patients with PsA (12.5%) had anti-CCP antibodies Patients with RA and anti-CCP antibodies had significantly higher disease activity, greater loss of function, and more frequent erosive disease than those with RA without anti-CCP antibodies In a subgroup analysis, anti-CCP antibodies in RF– patients with RA were also associated with erosive disease All patients with PsA and anti-CCP antibodies had symmetrical polyarthritis with higher number of swollen joints |
Yes |
| Baraliakos et al. [37] | Spinal deformities | Bone marrow edema | In a small study of patients with RA (n = 34) and AS (n = 6) complaining of neck pain, bone marrow edema was found in 21 patients with RA (62%) and three with AS (50%); however, the occurrence and severity of bone marrow edema did not correlate with neck pain severity | No |
| Michelsen et al. [38] | Peripheral arthritis | CDAI, DAS28, SJC, TJC, morning stiffness | In this cross-sectional study, DAS28 (P = 0.003) and CDAI (P = 0.028) were significantly higher in PsA vs. RA | Yes |
| IBP | BASDAI, BASFI | Patients with axSpA had significantly higher BASDAI (P = 0.009) and BASFI (P = 0.030) vs. those with RA or PsA | ||
| Spinal deformities | Spinal pain and stiffness | Patients with axSpA reported significantly more spine pain and stiffness at night vs. those with RA (P < 0.001) or PsA (P = 0.003) | ||
| Other | PtGA, pain and fatigue VAS | PGA and patient-reported pain and fatigue were significantly lower in RA (P < 0.015) vs. PsA or axSpA | ||
| Ceccarelli et al. [39] | Peripheral arthritis | Synovitis, DAS28 |
DAS28 values were significantly higher among patients with RA vs. PsA (P = 0.0001) Synovitis was significantly more prevalent and severe in RA vs. PsA (mean [SD] total ultrasound score of 13.1 [9.8] vs. 5.0 [6.5]; P = 0.0001, respectively) |
Yes |
| Reddy et al. [40] | Peripheral arthritis | Erosion, SJC, TJC |
SJC (P < 0.012) and TJC (P < 0.001) were significantly higher among patients with RA vs. PsA Joint erosions (P = 0.020) and deformity (P = 0.021) were significantly more prevalent in RA vs. PsA |
Yes |
| Other | mHAQ, pain | mHAQ (P < 0.001) and pain (P = 0.020) scores were significantly higher in RA vs. PsA | ||
| Cimmino et al. [41] | Peripheral arthritis | Synovitis | When patients with PsA and RA were matched for disease severity, dynamic MRI showed similar patterns of synovitis based on the mean (SD) rate of early enhancement (1.0 [0.6] and 1.3 [0.7], respectively) and relative enhancement (87.1 [39.2] and 107.3 [48.2], respectively) | No |
| Liphardt et al. [42] | Peripheral arthritis | Grip strength | Patients with RA had significantly lower grip strength vs. those with PsA, psoriasis, and the control group | Yes |
| Hand function | With regard to hand grip, those with RA, PsA, and psoriasis performed significantly worse vs. the control group | Yes | ||
| Fauny et al. [43] | Spinal deformities | Vertebral fractures | The prevalence of vertebral fractures was similar in patients with RA and AS | No |
| Batticciotto et al. [44] | Enthesitis | Erosion in MCP joints, paratenonitis |
Ultrasound showed that significantly more patients with early RA (5/20; 25%) had erosion in ≥ 1 MCP joint vs. those with early SpA (0/15; P = 0.036) Ultrasound showed that significantly more patients with early SpA (12/15; 80%) had paratenonitis of the extensor tendons in ≥ 1 finger vs. those with early RA (6/20; P = 0.003) |
Yes |
| Ichikawa et al. [45] | Peripheral arthritis | Erosion, joint osteolysis, juxta-articular bony proliferation | Radiography of the hands and feet revealed that juxta-articular bony proliferation is the most important factor differentiating PsA from S+ and S− RA (P < 0.001 for all) | Yes |
| Enthesis | Diffuse soft tissue swelling | Diffuse soft tissue swelling of the fingers and feet was significantly higher in patients with PsA vs. those with S+ RA (P < 0.001 for both) and S− RA (P = 0.005 and P = 0.004, respectively) | ||
| Lindqvist et al. [46] | Peripheral arthritis | SJC, TJC |
Authors compared disease characteristics of patients with PsA at enrollment in the Swedish Early PsA register (SwePsA) and at follow-up after 2 years; disease characteristics were also compared with those from the Swedish Early RA register (Ramona) At enrollment, patients with RA had a larger number of SJC (P < 0.0001) and TJC (P < 0.0001) compared with patients with PsA; at follow-up, patients with polyarticular PsA had significantly more TJC than those with RA |
Yes |
| Other | CRP, ESR, pain VAS, PtGA |
At enrollment, patients with RA had significantly higher mean ESR (P < 0.0001) and CRP (P < 0.0001) vs. those with PsA; additionally, those with early RA had a significantly higher mean HAQ score (P < 0.0001), pain (P = 0.0311), and PtGA (P < 0.0051) At the 2-year follow-up, ESR and CRP remained significantly higher in patients with RA (P < 0.0001 and P = 0.0001, respectively) vs. PsA Patients with RA had significantly higher ESR and CRP both on inclusion (P = 0.0003 and P = 0.0026, respectively) and 2 years later (P = 0.0026 and P = 0.0001) vs. those with polyarticular PsA At follow-up, patients with polyarticular PsA had significantly higher PtGA score vs. those with RA |
||
| Ramírez et al. [47] | Peripheral arthritis | Bursitis | No sonographic or MRI features were distinctive of SpA | No |
| Enthesitis | Tendinitis, enthesopathy | Neither ultrasound nor MRI was useful in classifying enthesitis in the great trochanter as mechanical or inflammatory | ||
| Hip damage or involvement | Erosion | A significantly higher proportion of patients with noninflammatory musculoskeletal disease had erosion in the gluteus minimus tendon (P = 0.038) as detected by ultrasonography vs. those with SpA | ||
| Harman et al. [48] | Peripheral arthritis | Synovitis |
Tibiotalar joint synovitis was observed on ultrasound significantly more frequently in patients with SpA and gout (P < 0.05) vs. those with RA and reactive arthritis; after 1 year, tibiotalar joint synovitis was observed more frequently in the RA group vs. SpA, gout, and reactive arthritis (P < 0.05) Subtalar and talonavicular joint synovitis were observed more frequently in the early RA group compared with the SpA, gout, and reactive arthritis groups (P < 0.05) |
Yes |
| Enthesitis | Tenosynovitis, tendinitis |
Tibialis posterior tenosynovitis was significantly more common in the RA group vs. the SpA, gout, and reactive arthritis groups (P < 0.001) Tibialis posterior tenosynovitis appeared to be more specific for RA, whereas Achilles’ tendinitis was more frequent in axial SpA and reactive arthritis |
||
| Abrar et al. [49] | Enthesitis | Bone erosion, tenosynovitis |
Patients with PsA had thicker flexor tendon pulleys vs. RA (mean difference, 0.16 mm; P < 0.001); this was accompanied by a higher degree of associated inflammatory changes (mean difference from RA, 4.7; P = 0.048) A strong correlation between accessory pulley inflammation and overall PsA MRI score as well as inflammatory PsA MRI subscores (flexor tenosynovitis, synovitis, and periarticular inflammation) was observed for almost all fingers |
Yes |
| Figus et al. [50] | Peripheral arthritis | Joint effusion, synovitis |
Although clinical examinations showed no differences between RA and PsA, ultrasound detected significant differences in the score of joint effusion (P < 0.021), synovial hypertrophy (P < 0.001), Doppler signal (P < 0.011), II MCF (P < 0.000), and wrist (P < 0.032) between oligoarticular PsA and RA No differences were found between RA and polyarticular PsA |
Yes |
| Murphy et al. [51] | Peripheral arthritis | Erosion, joint space narrowing |
At 1 year, the hand periarticular bone mineral density measurements were significantly lower in RA vs. SpA (P = 0.044) A decrease in hand periarticular bone mineral density of LSC > 2.04% was observed in 7 of 20 patients with RA (35%) vs. 3 of 18 patients with SpA (17%) A decrease in axial bone mineral density of LSC > 2.8% was observed in three patients with RA (15%) vs. 7 with SpA (39%) Persistent disease activity, measured by Ritchie articular index or CRP, was associated with a greater rate of periarticular bone loss in RA and a greater rate of axial bone loss in SpA |
Yes |
| Kruithof et al. [52] | Peripheral arthritis | Synovial histopathology |
Vascularity, and neutrophil and CD163+ macrophage counts were greater in SpA than RA (P < 0.05), but synovial lining layer thickness and the number of CD83+ dendritic cells were greater in RA (P < 0.05) In RA, 44% of histopathology samples had positive staining for intracellular citrullinated proteins, and 46% of MHC-HC gp39 peptide complexes vs. none of these markers in SpA samples When samples of patients who were treated with DMARDs and/or corticosteroids were excluded, vascularity (P < 0.001) and the number of neutrophils (P = 0.01) were increased in PsA vs. RA, and staining for intracellular citrullinated proteins and MHC-HC gp39 peptide complexes was present exclusively in RA |
Yes |
| Noche et al. [53] | Ophthalmic manifestations | Uveitis | Among 16 patients with RA and 8 patients with AS, anterior uveitis was observed in 6 of 8 patients with AS, and none with RA | Yes |
| Idolazzi et al. [54] | Enthesitis | Tenosynovitis, paratenonitis | Power Doppler signal at the nail bed enthesis was exclusively seen in patients with PsA vs. those with psoriasis, RA, and osteoarthritis and healthy controls | Yes |
| Psoriasis, nail psoriasis | – | The nail plate was significantly thicker in patients with PsA, psoriasis, and osteoarthritis vs. those with RA | ||
| D’Agostino et al. [55] | Enthesitis | Enthesopathy |
Of 164 consecutive patients presenting at a rheumatology clinic with SpA, 161 had ≥ 1 abnormal enthesis by ultrasound examination (the three patients without enthesitis had undifferentiated SpA, PsA, and reactive arthritis); 18 of 30 patients with RA (60%) had any abnormal entheses (P < 0.0001) Of 34 patients with SpA who underwent clinical examination, 88 of 612 entheses (14%) were deemed clinically abnormal in 21 patients (62%) and 220 of 612 entheses (36%) were considered abnormal by ultrasound in 32 patients (94%; P < 0.0001 for both) |
Yes |
| Falsetti et al. [56] | Enthesitis | Enthesopathy |
Of 900 shoulders examined among 450 symptomatic consecutive outpatients with SpA, RA, osteoarthritis, and controls, deltoidal proximal insertion enthesitis was detected in 10 shoulders, most frequently in PsA (17%) Ultrasonography revealed thickening and hypoechogenicity of the enthesis |
Yes |
| Cimmino et al. [57] | Peripheral arthritis | Synovitis | MRI studies revealed that the volume of inflammation was significantly higher in RA vs. PsA for two of three extensor compartments and in the joint synovial membrane (P = 0.002 and P < 0.001, respectively) | Yes |
| Roman-Ivorra et al. [58] | Peripheral arthritis | Modified Sharp/van der Heijde score | Patients with RA had worse mean modified Sharp/van der Heijde score than those with PsA (45.81 vs. 7.8) | Yes |
| Other | Hand and grip strength | Patients with RA presented with worse mean grip strength in both the left (11.02 vs. 20.06) and right (11.22 vs. 20.79) hands vs. those with PsA | ||
| Sandobal et al. [59] | Peripheral arthritis | Synovitis | Patients with PsA (106/350 joints) and psoriasis (8/200 joints) had increased power Doppler signal in the distal interphalangeal joints vs. those with RA (no signal; P = 0.0001); authors concluded that this was an indication of subclinical synovitis | Yes |
| Psoriasis, nail psoriasis | – | Patients with PsA (82/350 nails) and psoriasis (41/200 nails) had increased power Doppler signal in nail beds vs. those with RA (6/270 nails; P = 0.0001) | ||
| Schoellnast et al. [60] | Peripheral arthritis | Periostitis, bone cyst | Periostitis occurred more frequently in patients with PsA vs. RA (78 vs. 0%; P < 0.05) in MRI studies | Yes |
| Enthesitis | Bone marrow edema and erosion, tenosynovitis | Significantly more patients with RA showed bone erosions vs. those with PsA (86 vs. 17%; P < 0.05); however, nonsignificant differences were seen with regard to bone marrow edema, bone cysts, and tenosynovitis between the two groups | ||
| Bailly et al. [61] | Other | Pain, PtGA | Levels of pain and PtGA were numerically higher among patients with axSpA vs. RA | Yes |
| Cemeroğlu et al. [62] | Other | PGA, PtGA |
The mean (SD) PGA scores for patients with RA vs. AS were 4.1 (2.9) and 4.8 (2.8), respectively The mean (SD) PtGA scores for patients with RA vs. AS were 4.6 (2.4) and 4.9 (3.1), respectively |
No |
| Leeb et al. [63] | Peripheral arthritis | SJC, TJC |
Mean (SD) SJC for one PsA cohort and two RA cohorts (RA1 and RA2) were 1.6 (2.0), 1.9 (2.5), and 3.0 (3.7), respectively; a significant difference was found between the PsA and RA2 cohorts (P = 0.028) No difference in TJC was observed between the groups |
Yes |
| Other | DAS28 | Mean (SD) DAS28 scores for the PsA, RA1, and RA2 cohorts were 3.2 (1.3), 3.2 (1.5), and 3.8 (1.4), respectively; a significant difference was found between the PsA and RA2 cohorts (P = 0.006) | ||
| Harter et al. [64] | Hip damage/involvement | Fractures |
Adjusted hazard ratios were calculated for each outcome Patients with RA had a significantly elevated risk of fracture: all (1.23), hip (1.55), and vertebral (1.53) Those with mild psoriasis had significantly elevated risk of all (1.07) and hip (1.13) fractures Patients with severe psoriasis had significantly elevated risk of all (1.26) and vertebral (2.23) fractures Patients with PsA had a significantly elevated risk of all fracture (1.26) |
No |
| Illeez et al. [65] | Laboratory markers of inflammation | – |
Hemoglobin values were significantly lower for patients with RA vs. controls (P < 0.001) ESR, CRP, NLR (P < 0.001 for all), and PLR (P = 0.04) values were significantly higher in patients with RA vs. controls Patients with AS had significantly higher values for hemoglobin, ESR, CRP, and NLR (P = 0.001, P = 0.001, P = 0.006, and P = 0.001, respectively) vs. controls, whereas PDW values were significantly lower (P < 0.05) |
No |
| Ahmed et al. [66] | Peripheral arthritis | Joint effusion, synovitis |
Ultrasound findings of synovitis and erosions at the distal interphalangeal joints were exclusively observed in PsA vs. RA (P < 0.001) Joint effusion was frequently seen at radiocarpal and midcarpal joints in patients with RA vs. PsA (P = 0.047 and 0.039, respectively) Effusion at the third PIP joint was detected more significantly in PsA vs. RA (P = 0.037) |
Yes |
| Enthesitis | Tenosynovitis | Tenosynovitis was observed more frequently at the extensor tendons among patients with RA vs. PsA (P = 0.021) and at the flexor tendons in patients with PsA vs. RA (P = 0.022) | ||
| Ward et al. [67] | Entheseopathy | – |
Higher rates of PTT fiber disruption, PTT tenosynovial effusion, and Doppler signal (all P < 0.001) were observed in RA and SpA vs. healthy controls Patients with RA and SpA were 5.1 and 3.6 times more likely to exhibit ultrasound-detected pathology, respectively, than healthy controls (both P < 0.001) |
No |
| Helenius et al. [68] | TMJ symptoms | – |
Patients with rheumatic disease (RA, AS, and SpA) reported significantly more frequent severe TMJ symptoms vs. controls (P < 0.001) Mean (SD) maximum mouth opening was significantly less in patients with rheumatic disease (46.3 mm [8.6 mm]) vs. controls (55.0 mm [7.4 mm]; P < 0.001) Erosions were observed in 4 patients with RA (17%), 7 with AS (37%), and 8 with SpA (38%) |
No |
| Milutinovic et al. [69] | Enthesitis | Enthesopathy |
Using BUSES, authors distinguished 127 patients with enthesitis (76 with SpA, 26 with RA, and 25 with mechanically-related enthesitis) The mean (SD) BUSES was 9.9 (12.4) among those with SpA and 3.1 (4.2) among those without SpA (P < 0.001) |
Yes |
| Aletaha et al. [70] | Comorbidity | – |
Patients with AS, PsA, and RA had a 4.2%, 51.0%, and 3.4% 5-year cumulative incidence of psoriasis, respectively 5-year cumulative incidence of uveitis was 7.7% for patients with AS, 1.8% for those with PsA, and 1.5% for those with RA Patients with AS, PsA, and RA had significantly higher risk of developing any one or two of the six manifestations analyzed vs. controls (P < 0.002) |
No |
| Smerilli et al. [71] | Enthesitis | Pulley inflammation | Inflammation of the A1 pulley was observed by ultrasound in 15 of 240 fingers (6.3%) of 8 of 30 patients with PsA (26.7%) vs. 1 of 240 fingers (0.4%) of 1 of 30 patients with RA (P < 0.01 and P = 0.03, respectively) | Yes |
| Tinazzi et al. [72] | Enthesitis | Tenosynovitis, enthesopathy, peritendon edema |
Ultrasonographic findings of tenosynovitis, peritendinous soft tissue edema, and flexor tendon enthesopathy were more commonly observed in patients with PsA vs. RA (P < 0.001, P = 0.003, and P = 0.001, respectively), despite higher DAS28 score in RA When the three modifications of the flexor tendon were summed up per patient, the difference between PsA and RA remained significant (P < 0.001) |
Yes |
| Rothschild et al. [73] | Dactylitis | – | Dactylitis was observed in 18 of 150 patients with SpA, 7 of 106 with undifferentiated SpA, 6 of 27 with PsA, 0 of 5 with AS, and 0 of 96 with RA | Yes |
| Matschke et al. [74] | PT physical function | PROs |
PT stiffness was significantly reduced in patients with RA and AS vs. controls (P = 0.04 and P = 0.01, respectively) PT CSA was significantly larger leading to a reduction in YM in patients with AS (P = 0.04 and P < 0.001, respectively) Patients with RA and AS reported significantly lower scores for mHAQ (P < 0.001 and P < 0.01, respectively) and SF-36 PCS (P < 0.001 and P = 0.04, respectively) vs. controls, and SF-36 MCS score was significantly lower for patients with AS vs. controls (P = 0.03) |
No |
| Grosse et al. [75] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Radiography (mean total modified Sharp erosion score) and ultrasonography (total ultrasonography score for erosions; presence of ≥ 2 eroded joint facets) were (OR) 4.4 and 3.7 times higher among patients with CCP+ vs. CCP– RA, respectively The most discriminating joint between the two groups was MTP5, especially in cases with bilateral erosion (P < 0.001); both radiography and ultrasonography findings of bilateral erosions in the MTP5 joints were highly discriminant for patients with CCP+ RA (P < 0.001) CCP+ RA was associated independently with more severe erosive disease vs. CCP– RA on both radiography and ultrasonography |
Yes |
| Mouterde et al. [76] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Compared with S+ patients, S− patients had lower DAS28 (P = 0.002) and modified total Sharp score (P = 0.026) at baseline At year 3 of follow-up, DAS28 remission was similar, but the radiographic progression rate was lower in S− patients (P < 0.001) |
Yes |
| Slimani et al. [77] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | S− patients were older at the time of inclusion in the study (P = 0.03) and at RA diagnosis (P = 0.04), with less severe disease (SJC, P = 0.04; ESR P = 0.04; HAQ, P = 0.05; and remission rate, P = 0.04) vs. S+ patients | Yes |
| Liu et al. [78] | RA serostatus comparison | IA-irAE vs. RA serostatus | Mean (SD) CRP levels were 17.99 (21.90) and 27.93 (35.37) for patients with RA who were S+ and S−, respectively | No |
| Oprea et al. [79] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
More patients with S+ RA were associated with polyarticular damage vs. S− patients (97.78 vs. 80.95%) MCP and PIP joints were more frequently involved in S+ than S− patients (88.89 vs. 38.09%) Patients with S+ RA presented with more clinically active disease (≥ 5 swollen joints) than S− patients (33.33 vs. 23.81%) |
Yes |
| Barra et al. [80] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– and RF– (S−) |
S− patients with RA were more likely to be older and male vs. those with S+ RA (P < 0.001 for both) S− patients were also less likely to meet the 1987 ACR and 2010 ACR/EULAR criteria for RA; however, at baseline they had higher SJC (9 vs. 6), more erosive disease (32 vs. 23%), and higher DAS28 scores (5.00 vs. 4.75; all P < 0.05) vs. those with S+ RA Additionally, S− patients had shorter duration of symptoms (166 vs. 192 days; P = 0.007) S− patients had greater reductions in SJC (7 vs. 4) and similar DAS28 scores (2.97 vs. 2.83) at their 12-month follow-up vs. S+ patients (P = 0.0017 and P = 0.3, respectively) Adjusted analyses showed that S− patients were as likely to achieve DAS28 remission as S+ patients (OR, 1.18; 95% CI, 0.70 to 1.99); however, they were less likely to have erosive disease at follow-up (OR, 0.43; 95% CI, 0.19 to 0.95; P < 0.04) |
Yes |
| Deveci et al. [81] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Included were 48 patients with RA (proportion of RF+ patients, n = 27 [56.2%]) Anti-CCP antibodies were detected in 30.4% of RF– patients (n = 15) CCP positivity was associated with higher DAS28 scores and RF positivity |
Yes |
| Hamdi et al. [82] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | No difference in ultrasound DAS28 scores was observed among patients with RA, regardless of CCP or RF status | No |
| Asikainen et al. [83] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | Higher Larsen scores were observed in S+ patients with RA than in S− patients | Yes |
| Azuaga-Piñango et al. [84] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Globular synovitis was detected by ultrasound in 95.9% of S+ patients with RA vs. only three patients with S− RA (P < 0.001) Patients with globular synovitis had more erosions (72 vs. 33%; P < 0.0001), higher SJC, and higher synovial hypertrophy and power Doppler signal scores (all P < 0.001) than those without ultrasonographic globular synovitis |
Yes |
| Azuaga-Piñango et al. [85] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Although no significant differences in disease activity was observed between S+ or S− patients, ultrasonographic proliferative synovitis was observed in 55.5% of S+ patients (55.3% RF+ and 58.2% CCP+) vs. 16.1% S− patients (P = 0.0001) Univariate analyses revealed that significantly more patients with proliferative synovitis had erosive disease, higher ultrasonographic scores, and were more likely to be treated with csDMARDs (P = 0.0001, P = 0.0001, and P = 0.05, respectively) Multivariate analyses revealed that erosions (OR, 4.5; 95% CI, 2.17 to 11.07; P = 0.0001) and CCP positivity (OR, 3.5; 95% CI, 1.39 to 10.7; P = 0.09), but not RF positivity (OR, 0.74; 95% CI, 0.31 to 1.71; P = 0.483), were independently associated with the presence of proliferative synovitis |
Yes |
| Rauwel et al. [86] | RA serostatus comparison | HCMV+ vs. HCMV– |
Patients who were HCMV+ were less frequently CCP+ (49.8 vs. 58.9%; P < 0.0465) and had higher mean (SD) DAS28-ESR (5.55 [1.24] vs. 5.20 [1.14]; P < 0.0013) vs. those who were HCMV– At 1 year, bone erosion progression was lower in patients who were HCMV+ than those who were HCMV– (16.1 vs. 25.2%; P = 0.0128) |
Yes |
| Hermosillo [87] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Among 64 patients with very early RA (< 3 months from time at onset of clinical manifestations), 20 (31.2%) had very early S− RA Univariate analyses showed that those with very early S− RA were more likely to have minor disease activity, better functional state at their 3-, 6-, 9-, and 12-month follow-up, lesser work disability, and lower comorbidities, and were less likely to use sulfasalazine, leflunomide, biologics, and corticosteroids than those who had very early S+ RA |
Yes |
| Morales-Arango et al. [88] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Among 430 participants in a Maya-Yucateco cohort, 28 were diagnosed with RA (S+ RA, n = 9; S− RA, n = 17) The level of pain/discomfort, as assessed by EQ5D-3L dimension, was significantly higher among those with S+ RA than S− RA |
Yes |
| Shin et al. [89] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Among 109 patients analyzed, 64 (58.7%) had S+ RA and 45 (41.3%) had S− RA Those with S+ RA had more frequent ankle joint involvement, as visualized by radiography, and ANA expression (all P < 0.05) than those with S− RA Patients with S+ RA had higher levels of ESR and CRP than those with S− RA at initial diagnosis (all P < 0.01) and at their 2-year follow-up (all P < 0.01) DMARD combination therapy was more commonly used in the S+ group (P < 0.05), especially triple DMARD combination |
Yes |
| Sahatçiu-Meka et al. [90] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Patients with S+ RA showed more inflammation of the peripheral joints of hand and foot, but only inflammation of PIP joints was statistically significant, compared with those with S− RA (P < 0.01) With longer duration of disease, the “buttonhole” joint deformity was more prevalent among patients with S+ RA than those with S− RA (P < 0.05), and the “fibular deviation” joint deformity was more prevalent among those with S− RA than those with S+ RA (P < 0.01) |
Yes |
| Sahatçiu-Meka et al. [91] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | Inconclusive, no statistical differences found | No |
| Rajapaksa et al. [92] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Among patients with S+ RA, the prevalence of erosions (38 vs. 21%) and nodules (16 vs. 4%) was significantly higher than in those with S− RA (P < 0.05) Among patients with S+ RA, levels of IgM-RF positively correlated with erosions (P < 0.05); among those with S− RA, an inverse correlation was observed (P < 0.01) |
Yes |
| Shin et al. [93] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
CCP positivity was significantly associated with radiographic bony erosions (OR, 1.69; 95% CI, 1.13 to 2.52; P = 0.0096) vs. RF positivity (OR, 1.03; P = 0.83) or RF and CCP positivity (OR, 2.19; 95% CI, 1.19 to 4.01; P = 0.012) RF and CCP positivity were strongly associated with radiographic damage (OR, 4.93; 95% CI, 2.29 to 10.61; P < 0.0001) Multivariate analyses indicated that disease duration (estimate − 3.95; P < 0.0001) and RF titer (estimate + 0.0665; P = 0.0157) were associated with CCP titers |
Yes |
| Modi et al. [94] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Of 884 patients with RA in the RACER registry, 60% were RF+CCP+, 12% RF+CCP–, 10% RF–CCP+, and 18% RF–CCP– Patients with RF and CCP positivity had longer disease duration compared with the other groups (median, 143 vs. 88 to 93 months; P < 0.05) Morning stiffness was most common in the RF–CCP– group (54 vs. 26% to 40%), and rheumatoid nodules were more common in the CCP+ groups (12% to 15% CCP+ vs. 5% to 6% CCP–) (all P < 0.05) |
Yes |
| Shankar et al. [95] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
Among a cohort of 211 patients with established RA, anti-CCP2 positivity was a predictor of radiographic erosive disease in the hands (P < 0.001) Among patients with RF– RA, anti-CCP2 antibodies were observed in > 50% of patients and were associated with a higher incidence of erosive disease (P < 0.05) |
Yes |
| Fujinami et al. [96] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | No differences in histology scores of features were observed between patients with RF+ or RF– RA | No |
| Othman et al. [97] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | Among 80 adult patients with RA, authors observed a significant association between RF positivity and patients aged ≥ 50 years (P = 0.032) | Yes |
| Cappelli et al. [98] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) | Among 165 patients with RA, CCP negativity was significantly associated with greater fatigue (P = 0.03) | Yes |
| Choi et al. [99] | RA serostatus comparison | CCP+ and/or RF+ (S+) vs. CCP– or RF– (S−) |
At baseline, patients with S− RA had significantly higher mean (SD) TJC (4.7 [2.9] vs. 3.3 [2.7]; P = 0.004), SJC (4.3 [3.0] vs. 2.9 [2.3]; P = 0.001), and DAS28 (5.1 [1.0] vs. 4.7 [1.0]; P = 0.043) vs. those with S+ RA After 2 years of similar treatment with DMARDs across both groups, the mean (SD) ΔDAS28 at 1 year was greater among patients with S− RA than S+ RA (–2.84 [1.32] vs. –3.70 [1.29]; P = 0.037) in the high disease activity population (DAS28-ESR > 5.1) |
Yes |
ACR American College of Rheumatology, ANA antinuclear antibody, AS ankylosing spondylitis, axSpA axial spondyloarthritis, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, BMI body mass index, BUSES Belgrade Ultrasound Enthesitis Score, CCP cyclic citrullinated peptide, CDAI Clinical Disease Activity Index, CRP C-reactive protein, CSA cross-sectional area, csDMARDs conventional synthetic disease-modifying antirheumatic drugs, DAS28 Disease Activity Score in 28 joints, DAS28-ESR Disease Activity Score in 28 joints for RA with ESR, DMARD disease-modifying antirheumatic drug, EQ5D-3L EuroQoL 5-dimensional questionnaire-3 level, ESR erythrocyte sedimentation rate, EULAR European League Against Rheumatism, GUESS Glasgow Ultrasound Enthesitis Scoring System, HAQ Health Assessment Questionnaire, HCMV+ human cytomegalovirus seropositive, HCMV− human cytomegalovirus seronegative, IgM immunoglobulin M, irAE inflammatory arthritis induced by immune checkpoint inhibitors, IBP inflammatory back pain, LSC least squares change, MASEI Madrid Sonographic Enthesitis Index, MCP metacarpophalangeal, MCS SF-36 mental component summary, mHAQ modified Health Assessment Questionnaire, NLR neutrophil–lymphocyte ratio, OR odds ratio, PCS SF-36 physical component summary, PDW platelet distribution width, PGA physician global assessment of disease activity, PLR platelet-lymphocyte ratio, PIP proximal interphalangeal, PsA psoriatic arthritis, PtGA patient global assessment of disease activity, PT patellar tendon, PTT posterior tibialis tendon, RA rheumatoid arthritis, RF rheumatoid factor, S+ RA seropositive RA, S− RA seronegative RA, SF-36 Short-Form Health Survey, SJC swollen joint count, SpA spondyloarthritis, TJC tender joint count, TMJ temporomandibular joint, VAS visual analog scale, YM Young’s modulus
Enthesitis
A total of 29 studies reported data on enthesitis or enthesophytes (Fig. 2). Suboutcomes included tenosynovitis, pulley inflammation, soft tissue or bone marrow edema, entheseal erosion, and inflammation of the tendon or peritendon. Overall, 23 studies focused their evaluation on enthesitis, comparing imaging findings among patients with SpA and RA. Of these, only three concluded that there were no differences in this manifestation among patients with SpA vs. RA based on ultrasonographic [26, 32] and both ultrasonographic and MRI [47] findings (Table 3). In general, enthesitis on imaging was found almost exclusively in patients with SpA (particularly PsA) vs. RA, with few exceptions. Batticciotto and colleagues reported that significantly more patients with early RA had erosions in ≥ 1 MCP joint as visualized by ultrasound than those with early SpA, and significantly more patients with early SpA showed paratenonitis of the extensor tendons in ≥ 1 finger than those with early RA [44]. Tibialis posterior tenosynovitis appeared to be more specific for RA, whereas Achilles’ tendonitis was more frequent in axSpA and reactive arthritis [48]. Ahmed and colleagues reported that tenosynovitis was observed more frequently at the extensor tendons among patients with RA than those with PsA and at the flexor tendons in patients with PsA than those with RA [66]. While examining extrasynovial changes indicative of enthesitis by ultrasound, Fournié and colleagues described pseudotenosynovitis, characterized by diffuse inflammation of the digital soft tissue, in the fingers of patients with PsA; they conclude that pseudotenosynovitis may play a role in the development of dactylitis [28]. Of 34 patients with SpA who underwent careful clinical (i.e., physical) examination by an independent examiner, 88 of 612 entheses (14%) were deemed clinically abnormal in 21 patients (62%); however, with ultrasound imaging, 220 entheses (36%) were considered abnormal in 32 patients (94%) [55].
Psoriasis and/or Nail Psoriasis
Overall, 15 studies reported data on psoriasis and/or nail psoriasis (Fig. 2). Three focused their analyses on this clinical manifestation, comparing them among patients with PsA and RA; all three studies concluded that psoriasis and/or nail psoriasis occurred exclusively in patients with PsA vs. RA (Table 3) [23, 54, 59]. Of patients initially diagnosed with early seronegative RA, 25% were reclassified as having early PsA after presenting with cutaneous or nail psoriasis upon further rheumatology–dermatology evaluation [23]. One patient initially presented with seronegative oligoarthritis, and a diagnosis of PsA was suspected because of a family history of psoriasis; this patient was then formally diagnosed with PsA with the subsequent development of skin lesions [24].
IBP
Overall, 11 studies reported data on IBP (Fig. 2). Key outcomes assessed included Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index. Only one study evaluated IBP as a primary focus of the investigation (Table 3)—patients with axSpA had significantly higher Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index scores than those with RA [38].
Dactylitis
A total of nine studies reported data on dactylitis (Fig. 2). Three studies focused their evaluation on dactylitis among patients with PsA and RA; of these studies, the authors reported that dactylitis occurred exclusively in patients with PsA vs. RA (Table 3) [21, 33, 73].
Spinal Deformities
A total of seven studies reported data on spinal deformities (Fig. 2) [33, 37, 38, 43, 51, 64, 90]. Sub-outcomes included vertebral fractures and spinal pain and stiffness (Table 3). Overall, of three publications that evaluated spinal deformities as a primary focus of study, comparing this manifestation among patients with SpA and RA, only one study used imaging (computed tomography) and concluded that there were no differences between patients with SpA vs. RA [43].
Hip Involvement or Damage
A total of four studies reported data on hip involvement or damage (Fig. 2) [35, 47, 64, 90], two of which focused their evaluation on erosions and risk of fractures as a primary endpoint (Table 3). Neither study was able to differentiate between patients with SpA and RA with regard to this manifestation [47, 64].
PROs and Other Clinical Manifestations
Other manifestations evaluated included various PROs (pain, fatigue, PtGA, and Health Assessment Questionnaire), PGA, hand and grip strength, uveitis, CRP levels, erythrocyte sedimentation rate, DAS28, oligoarthritis, and body composition (Fig. 2). There were no studies that solely focused on differences in PROs between patients with SpA and RA; however, of the ten studies that incorporated PROs and other outcomes in their analyses among patients with SpA and RA, one concluded that there was no difference in PGA and PtGA among those with RA and AS (Table 3) [62]. Patients with PsA had significantly increased body mass index, waist circumference, and hip circumference vs. those with seropositive RA but not seronegative RA [35]. Anterior uveitis was exclusively observed in patients with AS vs. RA [53]. Patients with RA presented with worse mean hand grip strength than those with PsA [42, 58].
Clinical Manifestations and Outcomes in Seropositive and/or Seronegative RA vs. SpA
Of 25 studies comparing patients with seropositive and/or seronegative RA vs. SpA, only two studies concluded that no significant differences in RA disease activity can be delineated based on serostatus or in relation to SpA as measured by ultrasound, DAS28 [82], and histology [96] scores (Table 3). In general, although seronegative RA appeared to be milder in disease severity, pain, and discomfort than seropositive RA, Cappelli and colleagues reported that CCP− was significantly associated with greater fatigue, which persisted after adjusting for age, sex, race, and swollen joints [98]. MCP, PIP [79], and ankle [89] joints were more frequently involved in seropositive than seronegative patients. In a cross-sectional study comparing patients with seronegative RA with those who had seropositive RA, patients with AS, or healthy controls, more patients with seronegative RA presented with enthesopathy findings than those with seropositive RA. However, patients with AS had significantly higher findings of enthesopathy (e.g., bone erosion at the common extensor tendon, calcification of the Achilles’ tendon, and erosion at the triceps tendon) than those with seronegative RA [31]. In another cross-sectional study by Zabotti and colleagues, prevalence of peritendon inflammation indicative of enthesitis was significantly more common in patients with early PsA compared with those with seronegative RA (36 vs. 8%; P = 0.006) [23].
Discussion
Various overlapping clinical characteristics, both temporary and persistent, occur in SpA and RA, including inflammation and destruction of joints, pain, diminished functional ability, and increased risk for comorbidities; these overlapping clinical manifestations are mainly related to peripheral—and not spinal—manifestations. While the ASAS axial and peripheral SpA classification criteria do attempt to make this distinction, classification is not limited to those purely with axial or peripheral manifestations, which may contribute to likely reasons for misclassification of disease. Among patients with milder symptoms, negative serology, or those lacking definitive clinical signs, especially early in the disease course, determining the type of inflammatory arthritis may be challenging. In our analysis, we noted differences in the occurrence of SpA manifestations, not only among patients with SpA vs. RA, but also among those with early vs. late RA and by RA serostatus. Timelier and more comprehensive evaluation, especially aided by use of imaging techniques to evaluate peripheral manifestations such as enthesitis and peripheral arthritis, may reduce disease misclassification and inappropriate treatment.
The majority of the 79 studies reported on peripheral arthritis and enthesitis. Of 54 studies comparing SpA and RA study populations, only seven studies concluded that no distinction can be made between SpA and RA based on the SpA manifestations and outcomes examined [26, 32, 41, 43, 47, 62, 64]. Of 25 studies comparing patients with seropositive and seronegative RA, only two concluded that no significant differences in RA disease activity can be delineated based on serostatus [82, 96]. Although peripheral arthritis reportedly occurred at a similar frequency among patients with SpA and RA, distinct anatomical sites were involved [25, 27, 48, 66]. Two studies concluded that no distinction can be made between SpA and RA with regard to peripheral arthritis based on MRI [41] and ultrasonographic and MRI findings [47]. In their study, Cimmino and colleagues focused exclusively on the comparison of the degree of synovitis in the wrists of patients with PsA and RA using a low-field extremity-dedicated MRI device after accounting for disease activity [41]. The authors postulated that more sophisticated quantification tools may expose greater details of synovitis, allowing for better distinction of inflammation in SpA vs. RA; accordingly, in a later MRI study, they reported that the volume of inflammation was significantly higher in RA than PsA for two of three extensor compartments and in the joint synovial membrane [57]. In our analysis, enthesitis occurred almost exclusively among patients with SpA vs. those with RA, although three studies concluded that no distinction can be made between these two conditions based on ultrasonographic [26, 32] and both ultrasonographic and MRI findings [47]. As similar Madrid Sonographic Enthesitis Index [26] and Glasgow Ultrasound Enthesitis Scoring System [32] scores were noted among patients with RA and those with SpA, it may be interesting to follow up and observe the RA cohorts for the development of SpA because enthesopathy is a key SpA feature [100]. Psoriasis or nail psoriasis, IBP, dactylitis, and uveitis occurred exclusively among patients with SpA vs. RA. Based on PRO measures, the burden of disease was relatively equal between SpA and RA. While some studies did examine HLA-B27 as a laboratory measure in their patient population [24–26, 53, 55, 65, 69, 78], no comparisons were made between SpA and RA. As genetic and other biomarker assays become more validated as diagnostic tools to differentiate between specific disease states, this will hopefully address and potentially resolve some of the challenges associated with diagnosis highlighted here.
Technological advances in the development of more sophisticated imaging modalities and novel therapeutic interventions have greatly enhanced clinical practice with regard to disease detection, diagnosis, and management. The inclusion of imaging as a part of early diagnosis and differentiation of inflammatory arthritis underscores its significance, especially because similarities in synovitis and joint involvement and inflammation may be observed in SpA and RA [1, 17, 18]. In our analysis, ultrasonography and MRI were instrumental in detecting subclinical synovitis, entheseal inflammation, bone erosions, and bone marrow edema; in addition, two studies reported significant ultrasound findings that differentiated RA and SpA when routine clinical examinations could not [50, 55]. These reports may compel clinicians to pursue further investigation using advanced imaging modalities when presented with patients early in their course of inflammatory arthritis. Indeed, the role of imaging is multifaceted; in various clinical studies, imaging techniques may play a key role in ascribing the proper treatment course to patients based on diagnostic or prognostic information and in tracking treatment effectiveness and complications. Accordingly, imaging features such as flexor tenosynovitis, bone erosion, and regional inflammation beyond the joint may be indicative of early SpA development and pathophysiology. Consequently, biologic interventions approved for SpA may be prescribed for these patients to address their symptoms. A delay in accurate diagnosis and initiation of appropriate treatment confers substantial burden on patients and may result in increased healthcare costs [4, 7, 10].
Limitations
Various diagnosis criteria and outcome measures were used to classify and assess patients with SpA and RA, which may contribute to the heterogeneity of study populations among the studies. As most of the studies included in this review were conducted across Europe and Asia, the results may not be representative of all patients or healthcare systems. Advanced imaging modalities may not be widely available for use in clinical practice, especially among rural practices or medically underserved populations. Along with the limited number of studies with higher methodological quality and small patient population, these limitations precluded meaningful meta-analysis for the outcome measures assessed; thus, the results of our systematic literature review are descriptive in nature.
Conclusions
Overall, SpA manifestations were observed among patients with RA, especially those with early or seronegative disease, suggesting that misclassification could occur. The use of imaging may allow for a timely and thorough assessment of subclinical manifestations in SpA and RA, thus reducing misdiagnosis and inappropriate treatment. As effective, but not always overlapping, therapies for SpA and RA are available, imaging tools can be critical for accurate diagnosis and subsequent appropriate disease management. As next steps, the improvement and standardization of imaging protocols and interpretation can be undertaken to positively impact clinical outcomes and quality of life.
Supplementary Information
Below is the link to the electronic supplementary material.
Acknowledgements
Funding
Medical writing support for this study and the Rapid Service Fee were funded by Novartis Pharmaceuticals Corporation.
Authorship
All named authors meet the International Committee of Medical Journal Editors criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Author Contributions
Philip J. Mease, Mohit K. Bhutani, Steven Hass, Esther Yi, Peter Hur, and Nina Kim contributed to the concept and design of the article, performed the literature search and data analysis, and drafted and critically revised the manuscript. Authors had full control of the content and made the final decision on all aspects of this publication.
Medical Writing, Editorial, and Other Assistance
Medical writing support was provided by Kheng Bekdache, PhD, of Health Interactions, Inc, and was funded by Novartis Pharmaceuticals Corporation. This manuscript was developed in accordance with Good Publication Practice (GPP3) guidelines. The authors had full control of the content and made the final decision on all aspects of this publication.
Prior Presentation
An early, preliminary analysis of these data was shared as a poster presentation at the 2020 Annual European Congress of Rheumatology meeting (poster SAT0385).
Disclosures
Philip J. Mease has received research grants from AbbVie, Amgen, Bristol Myers Squibb, Celgene, Eli Lilly, Galapagos, Gilead Sciences, Janssen, Novartis, Pfizer, SUN, and UCB; consulting fees from AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead Sciences, GlaxoSmithKline, Janssen, Novartis, Pfizer, SUN, and UCB; and speakers bureau fees from AbbVie, Amgen, Eli Lilly, Janssen, Novartis, Pfizer, and UCB. Mohit K. Bhutani is an employee of Novartis Healthcare Pvt Ltd. Steven Hass is an employee of H.E. Outcomes, providing consulting services to Novartis Pharmaceuticals Corporation. Esther Yi is an employee of Novartis Pharmaceuticals Corporation. Peter Hur was an employee of Novartis Pharmaceuticals Corporation at the time of publication and is currently an employee of Pfizer, Inc. Nina Kim was a postdoctoral fellow at The University of Texas at Austin and Baylor Scott and White Health, providing services to Novartis Pharmaceuticals Corporation at the time of publication, and is currently an employee of Novo Nordisk.
Compliance With Ethics Guidelines
This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.
Data Availability
All data generated or analyzed during this study are available in this published article/as supplementary information files.
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Supplementary Materials
Data Availability Statement
All data generated or analyzed during this study are available in this published article/as supplementary information files.