Figure 8.

Administration of engineered adenoviruses suppresses tumor growth and prolongs survival of lung cancer bearing mice. (A) Bioluminescence images of subcutaneous tumor-bearing mice after administration of viruses. (B) Activity of viruses. (C) Amounts of viruses. (D) Tumor volume after administration of viruses. (E) Survival of subcutaneous tumor-bearing mice after administration of viruses. (F) Viral genome copies in the lungs after administration of viruses. (G) Immunofluorescent staining of lung tumors after administration of viruses. (H) Survival of orthotopic tumor-bearing mice after administration of viruses. (I) Bioluminescence images of orthotopic tumor-bearing mice after administration of viruses. (J) HE staining of lung tumor. Adapted with permission from ¹⁴³, Copyright 2020, The American Association for the Advancement of Science.