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. Author manuscript; available in PMC: 2022 Mar 30.
Published in final edited form as: Neuron. 2019 Apr 23;102(5):960–975.e6. doi: 10.1016/j.neuron.2019.03.036

Figure 6. Population Input from PNs to CGE INs.

Figure 6.

(A) Experimental design. Vc, voltage clamp; Ic, current clamp.

(B) Light stimuli (blue bars) evoked action potentials in infected PT PNs, without postsynaptic responses in INs. Depolarizing afterpotential (arrow). 10 overlaid trials.

(C) Long-duration (10 ms), high-power (26 mW) light stimuli (blue bars) were required to evoke rare, low amplitude postsynaptic responses in 5HT3A-GFP+ INs. Note doublet spiking in PT PN. 10 overlaid trials.

(D) Experimental design and example of 1.5 mW, 2 ms light stimuli evoked spikes. Lack of a depolarizing afterpotential (arrow). 10 overlaid trials.

(E) Amplitude of postsynaptic responses in CGE INs increase as a function of light power. 10 overlaid trials. Plotted are amplitudes of the first postsynaptic response evoked during a stimulus train, normalized to the lowest intensity (0.6 mW) (n = 5 cells). Error bars represent ± SEM.