Table 2.
Risk of mortality according to quartile of random albumin-creatinine ratio
| Outcome | Urine Albumin-Creatinine Ratio (mg/g) | |||||||
|---|---|---|---|---|---|---|---|---|
| Quartile 1 (<4.171) | Quartile 2 (4.171 to <6.211) | Quartile 3 (6.211 to <10.010) | Quartile 4 (≥10.010) | |||||
| Hazard Ratio (95% Confidence Interval) | P | Hazard Ratio (95% Confidence Interval) | P | Hazard Ratio (95% Confidence Interval) | P | Hazard Ratio (95% Confidence Interval) | P | |
| All-cause mortality | ||||||||
| Model 1a | 1.0 (ref) | 1.31 (1.17 to 1.47) | <0.001 | 1.82 (1.64 to 2.03) | <0.001 | 3.30 (2.99 to 3.64) | <0.001 | |
| Model 2b | 1.0 (ref) | 1.08 (0.96 to 1.21) | 0.18 | 1.27 (1.14 to 1.43) | <0.001 | 1.68 (1.51 to 1.87) | <0.001 | |
| Model 3c | 1.0 (ref) | 1.08 (0.95 to 1.22) | 0.20 | 1.25 (1.11 to 1.41) | <0.001 | 1.57 (1.41 to 1.76) | <0.001 | |
| Number of events, % | 539 (6) | 645 (7) | 865 (9) | 1467 (16) | ||||
| Cardiovascular mortality | ||||||||
| Model 1a | 1.0 (ref) | 1.52 (1.14 to 2.03) | 0.004 | 2.20 (1.68 to 2.88) | <0.001 | 4.98 (3.90 to 6.36) | <0.001 | |
| Model 2b | 1.0 (ref) | 1.18 (0.88 to 1.57) | 0.26 | 1.43 (1.09 to 1.88) | 0.01 | 2.20 (1.71 to 2.83) | <0.001 | |
| Model 3c | 1.0 (ref) | 1.28 (0.94 to 1.75) | 0.11 | 1.51 (1.12 to 2.03) | 0.006 | 2.14 (1.62 to 2.82) | <0.001 | |
| Number of events, % | 80 (0.8) | 111 (1) | 155 (2) | 330 (4) | ||||
ref, reference.
a
Unadjusted.
b
Adjusted for age, sex, race, and education.
c
Model 2 plus adjustment for body mass index, smoking, diabetes mellitus, hypertension, cardiovascular event, and baseline eGFR.