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. 2022 Feb 11;13(2):2951–2970. doi: 10.1080/21655979.2021.2024686

Figure 6.

Figure 6.

Effect of UTI combination with TM on serum cytokines and nitric oxide in rats and HMGB1/Toll-like receptor (TLR)4/Nuclear factor (NF)-κB pathway-related proteins in liver and kidney tissues.

(a) Changes in five groups of interleukin (IL)-6; (b) Changes in five groups of interleukin (IL)-1β; (c) Changes in five groups of tumor necrosis factor (TNF)-α; (D) Changes in five groups of serum nitric oxide (NO). (e) Protein levels of HMGB1, TLR4 and NF-κB in liver tissues; (f) Densitometric analyses of HMGB1 protein in liver tissues; (g) Densitometric analyses of TLR4 protein in liver tissues; (h) Densitometric analyses of P- NF-κB protein in liver tissues (i) Protein levels of HMGB1, TLR4 and NF-κB in kidney tissues; (j) Densitometric analyses of HMGB1 protein in kidney tissues; (k) Densitometric analyses of TLR4 protein in kidney tissues; (l) Densitometric analyses of P- NF-κB protein in kidney tissues. β-actin was used as the control to confirm equal protein loading. *P < 0.05 vs. the UTI group. #P < 0.05 vs. the TM group, ΔP < 0.05 vs. the Sham group, ☆P < 0.05 vs. the LPS group.