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. 2022 Feb 13;13(2):4226–4234. doi: 10.1080/21655979.2022.2027174

Figure 3.

Figure 3.

Circular-CDC like kinase 1 (circ-CLK1) directly targets miR-18b-5p. (a) Binding sites of circ-CLK1 and miR-18b-5p; (b) The luciferase activity of UM1 and HSC-2 cells co-transfected with luciferase reporter vector containing circ-CLK1 miRNA response elements (MREs) for miR-18b-5p and miR-18b-5p overexpression vector; (c) Circ-CLK1 expression after pulling down with miR-18b-5p; (d) miR-18b-5p expression in UM1 and HSC-2 cells. (e) miR-18b-5p expression in circ-CLK1 knockdown cells. **P < 0.01, *** P < 0.001 versus control.