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. 2022 Feb 19;13(3):5962–5974. doi: 10.1080/21655979.2022.2036900

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Increased level of ZFAS1 is positively correlated with elevated SRSF3 protein level and indicates a worse prognosis of osteosarcoma.

(a) ZFAS1 level was upregulated in osteosarcoma. Data from TCGA database. *p < 0.05. (b) ZFAS1 level was upregulated in osteosarcoma patient tissues compared to adjacent normal tissues. *p < 0.05. (c) Higher ZFAS1 levels indicated a poor prognosis of osteosarcoma. (d) SRSF3 expression was increased in osteosarcoma. Data from TCGA database. *p < 0.05. (e) SRSF3 protein level was upregulated in osteosarcoma patient tissues compared to adjacent normal tissues. Actin was served as the loading control. (f) ZFAS1 level was positively correlated with the SRSF3 protein level. (g) ZFAS1 expression in osteosarcoma cells compared to normal hFOB1.19 normal human osteoblast cells. (h) SRSF3 expression in osteosarcoma cells compared to normal hFOB1.19 normal human osteoblast cells. (I) Higher SRSF3 levels indicated a poor prognosis of osteosarcoma.