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Memantine prevented oxaliplatin-induced expression of NOX-2 in human SHSY-5Y neuronal cells. Cells were treated with oxaliplatin at 50 μM and Memantine at 5 and 10 µM for 24 hours. mRNA of NOX-2 as measured by real-time PCR (n = 6,**, P < 0.01 vs. vehicle group; #, ##, P < 0.05, 0.01 vs. oxaliplatin group).
