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. 2022 Jan 22;13(2):3503–3515. doi: 10.1080/21655979.2022.2029108

Figure 2.

Figure 2.

CircPTPN12 could sponge miR-21-5p in keloid fibroblasts. (a) CircPTPN12 contained a conserved binding site of miR-21-5p. (b) qRT-PCR was applied to detect the expression of miR-21-5p in keloid tissue. (c) qRT-PCR was applied to detect the expression of miR-21-5p in keloid fibroblasts. (d) The binding of circPTPN12 and miR-21-5p was verified by dual-luciferase reporter gene assay. (e, f)The combination of circPTPN12 and miR-21-5p was verified by RNA immunoprecipitation and pull-down assays. (g) qRT-PCR was used to detect the level of miR-21-5p after low expression of circPTPN12. (h) Pearson correlation analysis was used to detect the correlation between circPTPN12 and miR-21-5p in keloid tissue. *** P < 0.001.