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. 2021 Dec 13;36(4):970–982. doi: 10.1038/s41375-021-01490-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Kaplan–Meier survival curves of AML WT (n = 7; median survival 36 days), AML HET (n = 11), AML KO (n = 7) and MPN mice (n = 11; including Gab2 WT, HET, and KO mice). Significant differences in survival were evaluated by Mantel–Cox (log-rank) test followed by the Bonferroni-Dunn method to adjust for multiple comparisons. Body weight (B) and WBC (C) counts in PB over time for mice with the indicated genotypes. Individual values for every measurement are shown; the connecting line indicates the mean. Data for AML WT mice are missing from week 6 onwards as all mice from this group had reached an ethical endpoint by this time. Statistics were calculated using mixed-effects analysis with Tukey’s multiple comparison test; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.