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. Author manuscript; available in PMC: 2022 Apr 5.
Published in final edited form as: Neuropharmacology. 2020 Feb 14;168:108009. doi: 10.1016/j.neuropharm.2020.108009

Fig. 1. Acute administration of pimavanserin plus lorcaserin does not suppress cocaine self-administration.

Fig. 1.

(A) Effects of acute pimavanserin (0.3, 1, 3 mg/ kg) on total cocaine infusions (mean ± SEM) are presented (n.s. vs. control). (B) Effects of acute lorcaserin (0.25, 0.5, 1 mg/kg) to alter total cocaine infusions (mean ± SEM) are presented. Lorcaserin (1.0 mg/kg) suppresses cocaine intake relative to control (*p < 0.05 vs. control; left panel); this effect is prevented by the selective 5-HT2CR antagonist SB242084 (right panel). (C) Effects of subthreshold doses of pimavanserin (PIM; 0.5 mg/kg) plus lorcaserin (LOR; 0.5 mg/kg) on total cocaine infusions (mean ± SEM) are presented (n.s. vs. control).