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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 2000 Apr;44(4):1119.

Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1

Angela D M Kashuba 1, John R Dyer 1, Linda M Kramer 1, Ralph H Raasch 1, Joseph J Eron 1, Myron S Cohen 1
PMCID: PMC89831

Volume 43, no. 8, p. 1817–1826. 1999. Page 1819: Table 2

Table.

Drug pKa CPR/CP CSV/CP Cother/CP CS/CP
Weak acids
 Didanosine 9.1 1.0 1.0 1.0 1.0
 Zidovudine 9.7 1.0 1.0 1.0 1.0
 Efavirenz 10.2 1.0 1.0 1.0 1.0
 Nelfinavir 11.1 1.0 1.0 1.0 1.0
Weak bases
 Abacavir 5.1 1.0 1.0 1.0 1.0
 Lamivudine 4.3 1.0 1.0 1.0 1.0
 Zalcitabine 4.4 1.0 1.0 1.0 1.0
 Indinavir 6.2 1.4 1.0 1.0 1.1
 Ritonavir 2.8 1.0 1.0 1.0 1.0
 Saquinavir 1.1/7.1 1.0–3.3 ∼1.0 ∼1.0 ∼1.5
 Delavirdine 4.6 1.0 1.0 1.0 1.0
 Nevirapine 2.8 1.0 1.0 1.0 1.0

should appear as shown below.


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