Table 2.

Five elements of outcomes

	Domain	Specific measurement	Specific metric	Method of aggregation	Time point
Primary outcome	The Modified Rankin Scale (mRS) score	The Modified Rankin Scale (mRS) score	Change from baseline to 14, 28, 60, 90, and 180 days	Proportional-odds logistic-regression model	Baseline, 14, 28, 60, 90, and 180 days
Secondary outcome	National Institutes of Health Stroke Scale (NIHSS) score	National Institutes of Health Stroke Scale (NIHSS) score	Change from screening period to 14, 28, 60, and 90 days	Repeated-measures analysis model	Screening period, 14, 28, 60, and 90 days
	Activity of Daily Living (ADL) Scale score (Barthel index)	Activity of Daily Living (ADL) Scale score (Barthel index)	Change from baseline to 90 and 180 days	Repeated-measures analysis model	Baseline, 90 and 180 days
	Prothrombin time (PT)	Prothrombin time (PT)	Change from baseline to 14, 28, 60, and 90 days	Repeated-measures analysis model	Baseline, 14, 28, 60, and 90 days
	Activated partial thromboplastin time (APTT)	Activated partial thromboplastin time (APTT)	Change from baseline to 14, 28, 60, and 90 days	Repeated-measures analysis model	Baseline, 14, 28, 60, and 90 days
	Serum fibrinogen (FIB) concentration	Serum fibrinogen (FIB) concentration	Change from baseline to 14, 28, 60, and 90 days	Repeated-measures analysis model	Baseline, 14, 28, 60, and 90 days
	Serum hypersensitive C-reactive protein (hs-CRP)	Serum hypersensitive C-reactive protein (hs-CRP)	Change from baseline to 90 days	Repeated-measures analysis model	Baseline, 90 days