Figure 2.

Potential mechanisms of m6A methylation in the regulation of CMDs. FTO regulates calcium-ion homeostasis by increasing the protein expression of SERCA2a, and regulates the circadian rhythm by inhibiting the expression of BMAL1. Deletion of BMAL1 leads to the accumulation of ROS, which in turn regulates the expression of Lpin1 and PPARα by increasing the expression of METTL3. YTHDF2 and METTL3 jointly affect the transcription and translation of PPARα and regulate lipid metabolism. Moreover, silencing of METTL3 upregulates TFEB expression, thereby enhancing autophagy. FTO also promotes autophagy by upregulating the expression of ULK1 and LC3II. METTL3 reduces inflammation by inhibiting the NF-κB pathway and upregulates the expression of STAT1 to promote M1 macrophage polarization. “→” refers to promotion, “—ǀ” refers to suppression.