Table 1.

The roles of m6A methylation in CMDs. ——: not mentioned.

Cardiovascular Diseases	m6A-Related Molecules	Expression	Target RNAs	m6A Levels	Main Functions	Reference
Obesity	FTO	Upregulated	Runx1t1	——	Regulates mitosis of fat precursor cells and promotes adipogenesis	[43,44]
	YTHDF1	Upregulated	MTCH2	——	Increases fat accumulation in muscle	[45,46]
	WTAP/METTL3/METTL14 complex	Upregulated	——	Increased	Knockout of this complex causes cell-cycle arrest and reduces adipogenesis	[47]
Pulmonary hypertension	METTL3	Upregulated	——	Increased	Upregulates proliferation and migration of PASMCs	[52]
	——	——	circXpo6 and circTmtc3	Reduced	Possibly affects the circRNA–miRNA–mRNA network	[53]
Ischemic heart disease	METTL3	Upregulated	TFEB	Increased	Inhibits autophagy and promotes apoptosis in cardiomyocytes	[57]
	ALKBH5	Downregulated	YTHDF1	Increased	Promotes the proliferation of cardiomyocytes in mice with myocardial infarction by demethylating YTHDF1 mRNA; improves heart function	[59]
	FTO	Downregulated	SERCA2a	Increased	Overexpression of FTO inhibits myocardial fibrosis and cellular apoptosis, promotes angiogenesis, and improves cardiac systolic function	[56]
Cardiac hypertrophy	METTL3	Upregulated	MAP3K6, MAP4K5 and MAPK14	Increased	Induces remodeling in compensatory cardiac hypertrophy	[65]
	FTO	Downregulated	Mhrt	Increased	FTO overexpression inhibits H/R-induced cardiomyocyte apoptosis	[70,71]
Atherosclerosis	METTL14	Upregulated	miR-19a	Increased	Promotes the proliferation and invasion of vascular endothelial cells	[76]