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Disruption of tight junctions in mouse lung with LPS treatment. (a) Normal ZO-1 distribution in healthy mouse lungs (left panel: yellow arrow). (b) Reduced expression and disorganized structure of ZO-1 (right panel: yellow arrow) in the lungs of mice (C57BL6/J, 6–8 weeks) treated with LPS (10 mg/kg, intranasally). Mice were sacrificed after 24 h-infection [65].
