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. 2022 Mar 22;11(7):1067. doi: 10.3390/cells11071067

Figure 7.

Figure 7

Psoralen activates the AMPK/ACC pathway by activating AMPK. (A) L02 cells were induced with sodium oleate (100 μM) for 24 h and treated with psoralen at 0.37, 1.1, and 3.3 μM for 24 h. The expression of AMPK, p-AMPK, ACC, and p-ACC was detected by Western blotting. (B) The expression of LKB1 and p-LKB1 was detected by Western blotting. (C) Sodium oleate-induced L02 cells were treated with psoralen (3.3 μM) alone or in combination with compound C (10 μM) for 24 h. The expression of AMPK and p-AMPK was determined by Western blotting. (D) L02 cells were transfected with siAMPKα or scramble, induced with sodium oleate (100 μM) for 24 h, and treated with psoralen (3.3 μM) for 24 h. The expression of ACC and p-ACC was measured by Western blotting. Abbreviations: AMPK, adenosine 5′-monophosphate (AMP)-activated protein kinase; ACC, acetyl-CoA carboxylase; Comp C, compound C; Pso, psoralen; FASN, fatty acid synthase.