Table 3.
Relative changes of body weight, total kidney fat content, renal cortex fat and sinus fat content, creatinine and glomerular filtration rate (GFR) from baseline to week 12 and from baseline to week 50; n = 137.
| Baseline | Week 12 | Loge Relative Change | p | Week 50 | Loge Relative Change | p | ||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | (Week 12) | Mean ± SD | (Week 50) | ||||
| Weight (kg) | Q1 | 94.8 ± 15.7 | 94.8 ± 15.6 | 0.0 ± 0.2 | <0.0001 * | 96.1 ± 16.1 | 1.3 ± 0.6 | <0.0001 * |
| Q2 | 93.7 ± 14.4 | 90.7 ± 14.0 | −3.3 ± 0.1 | 93.3 ± 13.9 | −1.3 ± 0.5 | |||
| Q3 | 93.9 ± 15.3 | 88.4 ± 14.4 | −6.1 ± 0.2 | 89.8 ± 15.8 | −4.4 ± 0.8 | |||
| Q4 | 94.7 ± 14.4 | 84.4 ± 12.8 | −11.5 ± 0.6 | 84.8 ± 14.2 | −11.2 ± 1.6 | |||
| Total kidney fat content (%) | Q1 | 58.9 ± 18.5 | 54.9 ± 18.6 | −6.8 ± 4.4 | 0.009 * | 57.4 ± 19.5 | −3.7 ± 3.8 | 0.002 * |
| Q2 | 52.3 ± 18.4 | 49.8 ± 17.1 | −5.5 ± 4.0 | 55.2 ± 17.6 | 6.7 ± 3.5 | |||
| Q3 | 52.0 ± 16.8 | 46.8 ± 16.0 | −13.2 ± 5.5 | 49.2 ± 18.4 | −8.4 ± 5.1 | |||
| Q4 | 52.8 ± 13.3 | 43.7 ± 13.4 | −21.3 ± 5.8 | 45.5 ± 16.5 | −21.4 ± 5.0 | |||
| Kidney cortex fat content (%) | Q1 | 3.6 ± 1.8 | 3.4 ± 1.5 | −5.0 ± 10.0 | 0.97 | 3.5 ± 1.7 | −7.5 ± 11.9 | 0.77 |
| Q2 | 3.2 ± 1.2 | 3.1 ± 1.1 | 0.2 ± 8.3 | 3.3 ± 1.7 | 3.1 ± 10.6 | |||
| Q3 | 2.9 ± 1.2 | 3.3 ± 1.8 | 11.7 ± 11.2 | 2.6 ± 1.1 | −10.5 ± 11.3 | |||
| Q4 | 3.4 ± 1.8 | 2.9 ± 1.8 | −15.7 ± 11.6 | 2.9 ± 1.0 | −9.4 ± 9.2 | |||
| Kidney sinus fat content (%) | Q1 | 55.3 ± 18.3 | 51.5 ± 18.3 | −6.4 ± 5.1 | 0.02 * | 53.9 ± 19.5 | −3.2 ± 4.8 | 0.001 * |
| Q2 | 49.2 ± 18.4 | 46.7 ± 16.9 | −5.4 ± 4.2 | 52.0 ± 17.3 | 7.3 ± 3.8 | |||
| Q3 | 49.1 ± 16.8 | 43.4 ± 16.1 | −15.4 ± 6.3 | 46.5 ± 18.5 | −8.6 ± 5.7 | |||
| Q4 | 49.4 ± 13.2 | 40.7 ± 13.0 | −21.3 ± 6.3 | 42.7 ± 16.1 | −22.0 ± 5.4 | |||
| Creatinine | Q1 | 0.783 ± 0.133 | 0.809 ± 0.136 | 2.8 ± 1.4 | 0.02 * | 0.805 ± 0.131 | 3.0 ± 1.6 | 0.77 |
| Q2 | 0.831 ± 0.125 | 0.84 ± 0.127 | 2.0 ± 1.3 | 0.833 ± 0.134 | −1.1 ± 1.2 | |||
| Q3 | 0.771 ± 0.122 | 0.795 ± 0.108 | 3.4 ± 1.3 | 0.809 ± 0.144 | 4.8 ± 1.4 | |||
| Q4 | 0.789 ± 0.103 | 0.773 ± 0.132 | −2.5 ± 1.8 | 0.815 ± 0.107 | 2.2 ± 2.0 | |||
| GFR | Q1 | 100.6 ± 6.9 | 99.6 ± 7.2 | −1.0 ± 0.5 | 0.04 * | 99.6 ± 6.7 | −1.0 ± 0.6 | 0.65 |
| Q2 | 99.2 ± 6.2 | 98.5 ± 5.9 | −0.8 ± 0.5 | 99.8 ±7.1 | 0.8 ± 0.7 | |||
| Q3 | 100.3 ± 12.4 | 99.1 ± 10.1 | −0.8 ± 0.8 | 97.9 ± 12.3 | −2.1 ± 0.7 | |||
| Q4 | 103.1 ± 8.0 | 104.3 ± 8.7 | 1.1 ± 0.7 | 102.3 ± 7.3 | −0.8 ± 0.8 |
* p = significant at the 0.05 level (two tailed). Data are shown as mean ± SD and as mean ± SEM for week 12 and week 50 for Loge relative change with baseline values as reference. p-values of the four weight loss quartiles were calculated with linear mixed models adjusted for sex and age (baseline to week 12, baseline to week 50). Abbreviations: GFR, glomerular filtration rate; SD, standard deviation; SEM, standard error of the mean.