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. 2022 Apr 12;11:e67621. doi: 10.7554/eLife.67621

Figure 5. Three months of JUUL aerosol inhalation alters pro-inflammatory markers in colon.

Inflammation was assessed in the colon at 1 and 3 months. Panels show inflammation markers in the colon in Tnfa (A) 1 month and (B) 3 months, Il6 at (C) 1 month and (D) 3 months, Il1b at (E) 1 month and (F) 3 months,Il8 (G) and (H), and Ccl2I 1 month and (J) 3 months. Data for inflammation markers is presented as individual data points ± SEM. * p < 0.01 and ** p < 0.001.

Figure 5.

Figure 5—figure supplement 1. Inflammatory gene expression changes in the colon of mice exposed to JUUL Mango and JUUL Mint.

Figure 5—figure supplement 1.

These data are graphed with each exposure type (air – blue, mango – orange, and mint – green) grouped for ease of comparison of gene expression at 1 month (white columns) and 3 months (solid columns) of exposure. Notably, inhalation of JUUL Mango aerosols three times daily for 1 month led to increased expression of Tnfa, Il6, and Il8 in the colon. Data were analyzed with one-way ANOVA with Holm-Sidak multiple comparisons for each gene of interest. Data are presented as individual data points ± SD with n = 5–6 mice per group. *p < 0.05, **p < 0.01, *** p < 0.001 and **** p < 0.0001.