Paul Borodin1, Eugene Borodin 1, Leila Nagieva1
1Amur State Medical Academy, Russia
Background and Aims: The COVID‐19 pandemic initially was considered mainly as respiratory disease. At present, it has become obvious that the SARS‐Cov2 virus has a tropism for various organs and tissues, causes their damage and COVID‐19 represents a multi‐organ disease. The aim of this work was to summarize the results of 7 meta‐analyzes, published within 2020‐2021 and devoted to the damage to the nervous system in patients with COVID‐19.
Methods: Of the 28,910 publications (randomized controlled trials, non‐randomized controlled trials, case‐control studies, cohort studies, cross sectional studies, case series, and case reports) included in the electronic databases PubMed, MEDLINE, Web of Science, Scopus, EMBASE, Google Scholar, EBSCO, Cochrane Library, WHO database, ClinicalTrials.gov only 483, that meet the inclusion criteria, were selected for meta‐analyses.
Results and Conclusions: The incidence of neurological complications decreased in order of disturbance of smell and taste> weakness> myalgia> headaches> dizziness. Оne of the rare complications of Covid‐19 is Guillain‐Barré syndrome. The most prevalent neurological comorbidity in COVID‐19 was cerebrovascular disease (ischemic strokes> hemorrhagic strokes> cerebral venous thrombosis). Thus, 30‐33% of COVID‐19 patients develop neurological manifestations and complications. The study of the pathogenetic mechanisms of the development of neurological complications in patients with COVID‐19 will make it possible to propose indicators for predicting the likelihood of developing these complications and to develop methods for their prevention.
