P1‐95: It runs in the family: case series of severe and critical COVID‐19 in three family members

Archangel Manuel ¹, Joven Roque Gonong¹

¹Lung Center of the Philippines, Quezon city, Philippines

We report three cases of blood related family members who developed severe and critical COVID‐19. All of the family members were male and had the same blood type A, Rhesus positive. The two older members had hypertension as comorbidity. The youngest member had no comorbid condition except for obesity as a risk factor for severe disease. Two of the members ( eldest and youngest) had body mass index (BMI) classified as overweight and obese. Studies have shown factors predisposing certain people to severe and critical COVID‐19 like older age, certain comorbidities like cardiovascular disease, diabetes, chronic respiratory disease, cancer, and obesity. Some genetic factors were also link to severe and critical COVID‐19, for example the increase predisposition of patients with blood type A or AB to severe and critical COVID and presence of receptors like ACE2, TMPRSS2, sialic acid receptors, and CD147 which mediate viral entry to host cells. In this case series, risk factors observed were older age > 50 years old, hypertension, male gender, blood type A, and obesity which might contributed to severe and critical COVID‐19 in this family cluster. Unfortunately the two older members of this family died of the disease and its complications. Only the younger member with less risk factors survived.