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. 2021 Dec 29;45(8):4625–4642. doi: 10.1002/mma.8057

A fractional‐order mathematical model for analyzing the pandemic trend of COVID‐19

Praveen Agarwal 1,, Mohamed A Ramadan 2, Abdulqawi A M Rageh 2,3, Adel R Hadhoud 2
PMCID: PMC9015554  PMID: 35464830

Abstract

Many countries worldwide have been affected by the outbreak of the novel coronavirus (COVID‐19) that was first reported in China. To understand and forecast the transmission dynamics of this disease, fractional‐order derivative‐based modeling can be beneficial. We propose in this paper a fractional‐order mathematical model to examine the COVID‐19 disease outbreak. This model outlines the multiple mechanisms of transmission within the dynamics of infection. The basic reproduction number and the equilibrium points are calculated from the model to assess the transmissibility of the COVID‐19. Sensitivity analysis is discussed to explain the significance of the epidemic parameters. The existence and uniqueness of the solution to the proposed model have been proven using the fixed‐point theorem and by helping the Arzela–Ascoli theorem. Using the predictor–corrector algorithm, we approximated the solution of the proposed model. The results obtained are represented by using figures that illustrate the behavior of the predicted model classes. Finally, the study of the stability of the numerical method is carried out using some results and primary lemmas.

Keywords: basic reproduction number, COVID‐19, equilibrium point, fractional‐order derivative, predictor–corrector algorithm

1. INTRODUCTION

The WHO announced COVID‐19 to be a pandemic epidemic on January 22, 2020. Nowadays, the pandemic is spreading across the world and affects almost every aspect of life. In addition to health problems, it undermines the global economic system and restricting people's contact. Researchers from diverse scientific fields have therefore committed themselves to the study of COVID‐19. The objectives were to contribute to the enhancement of the comprehension, forecast, and interpretation from different points of view for this disease. Any new suggestions are a step forward in solving this health crisis. Mathematical models are a significant and efficient way to comprehend epidemic transmission dynamics. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 These models can be helping predict disease transmission and thus help decision makers in planning and make necessary decisions.

The fractional‐order models provide a more accurate fit than the integer‐order models for the actual data for various diseases and other experiential studies around modeling and simulation. New mathematical models of fractional order are developed that can be used for simulation to forecast the disease outbreaks and flatten the infection and deaths curve. 10 , 11 , 12 , 13 , 14 The mathematicians have also put their efforts forward in the analysis of various nonlinear dynamics of problems related to the infection like epidemics. 15 , 16 , 17 , 18 Khan and Atangana 19 described the mathematical modeling and dynamics of a novel coronavirus (2019‐nCoV), then formulated a new mathematical model for simulation of the dynamics COVID‐19 with quarantine and isolation. 20 Atangana 21 proposed a model for the spread of COVID‐19, with new fractal‐fractional operators and taking into account the potential of transmission of COVID‐19 from dead bodies to humans and the effect of lockdown. Yadav and Verma 22 investigated a fractional model based on Caputo–Fabrizio fractional derivative and developed for simulation the transmission coronavirus (COVID‐19) in Wuhan Chinese.

Baleanu et al 23 used the homotopy analysis transformation method to solve the COVID‐19 transmission model with Caputo–Fabrizio derivative. Erturk and Kumar 24 used the corrector–predictor algorithm with a new generalized Caputo type derivative to solve the novel coronavirus (COVID‐19) epidemic fractional‐order model. Abdulwasaa et al 25 generalized a mathematical model based on a fractal‐fractional operator to forecast future trends in the behavior of the COVID‐19 pandemics in India for October 2020. Rezapour et al 26 provided the SEIR model of the spreading epidemic of the COVID‐19 globally and Iran for data reported from December 31, 2019, to January 28, 2020. Shaikh et al 27 , 28 analyzed the fractional‐order COVID‐19 model for simulating the potential transmission of epidemic and suggested some possible control strategies. Zhang et al 29 proposed and applied the time‐dependent SEIR model to fit the time series of coronavirus evolution observed recently in China and then predict transmission. Matouk 30 analyzed complex dynamics in a model for COVID‐19 and its fractional‐order counterpart with multidrug resistance. Tang et al 31 adopted a deterministic model that was devised based on the clinical improvement to illuminate the dynamics for transmission of the novel coronavirus and determine the effect of the public health measures on the infection.

The paper is arranged as follows: In Section 2, we recalled some basic concepts and results used in the article. In Section 3, we developed the model pandemic trend Covid‐19 with fractional order then calculated the basic reproduction number and equilibrium points along with sensitivity analysis for parameters. Using the fixed‐point theory, the existence and uniqueness analysis of the model was performed in Section 4. In Section 5, we presented a numerical algorithm for solving the model based on the predictor‐corrector method. In Section 6, we discussed the stability of the numerical method. In Section 7, we have displayed the numerical simulation results for the real data. A conclusion completes the paper.

2. BASIC CONCEPT

In this section, we present some of the fundamental definitions and rand results of fractional order derivatives which, can be used throughout this manuscript.

Definition 1

(Samko et al. and Miller and Ross 32 , 33 ) For an integrable function f(t), the Caputo derivative of fractional order α ∈ (0, 1) is given by

CDtαf(t)=1Γnα0tf(n)(τ)tταn+1dτ,n=[α]+1. (1)

The corresponding fractional integer of order α with Re(α) > 0 is given by

CItαf(t)=1Γ(α)0tf(τ)tτ1αdτ. (2)

Lemma 1

(Li and Zeng 34 ) If 0 <α < 1 and n≥0 is an integer, then there exists the positive constants α,1 and α,2 only dependent on α, such that

(n+1)αnαα,1(n+1)α1, (3)

and

(n+2)α+12(n+1)α+1+nα+1α,2(n+1)α1. (4)

Lemma 2

(Li and Zeng 34 ) Assume that ak,n=nkα1,k=1,2,,n1 and ak,n=0 for kn,  α, h, L, T > 0,  τh ≤ T where τ is a positive integer. Let k=mnak,nek=0 for m > n≥1. If

enLhαk=1n1ak,nek+ζ0,n=1,2,,τ, (5)

then,

enζ0,τ=1,2,, (6)

where is appositive constant independent of h and τ.

Lemma 3

(Diethelm 35 ) The function y ∈ C[0, T] is a solution of the following fractional differential equation:

CDtαy(t)=ft,y(t),y(0)=y0, (7)

if and only if it is a solution of the nonlinear Volterra integral equation of the second kind

y(t)=y(0)+1Γ(α)0ttτα1fτ,y(τ)dτ. (8)

3. THEORETICAL APPROACH

In this section, we are considered to examine a classical model developed by Fatima et al 1 for the pandemic trend of 2019 coronavirus, which was first identified in the Chinese city of Wuhan in December 2019 and then spread quickly across the world. The population is divided into six subcategories: susceptible people denoted by S, exposed people E, infected people I, asymptomatic infectious people A, isolated or hospitalized people H, recovered or dead people R, and the reservoir for COVID‐19 is denoted by W. The pandemic trend model of COVID‐19 is given by the system of ordinary differential equations as follows:

S˙=Υξ1SI+σA+ψHξ2WSδS,Ė=ξ1I+σA+ψH+ξ2WSν+δE,İ=νηEβ1+β2+δI,A˙=ν1ηEρ+δA,H˙=β1I+ρAβ3+δH,R˙=β2I+β3HδR,W˙=θ1I+θ2AλW. (9)

Subject to non‐negative initial conditions.

S(0)=S0,E(0)=E0,I(0)=I0,A(0)=A0,H(0)=H0,R(0)=R0,W(0)=W0, (10)

where Υ=b×N,b is the birth rate, and N is the total number of people; δ the death rate of the population; ξ 1 and ξ 2 denote the rate of transmission infected of the susceptible people through sufficient contact with I and W, respectively. The parameters σ and ψ denote the approximate transmissibility from A and H to I, respectively. (ν)−1 represented the transmission rate after the quarantine period and joined the class I and A. The parameters η and (1 − η) are the moving rate from E to I and A, respectively. The rate of infected people who are hospitalized is β 1, and β 2 is the recovery rate. β 3 denotes the recovery rate of hospitalized patient. θ 1 and θ 2 are the infected and asymptomatically infected populations contributing to the reservoirs coronavirus, respectively. λ is the lifetime of the virus.

Now, we modify Equations (9) and (10) by putting the Caputo fractional derivatives instead of the time derivatives; with this move, the dimensions on both sides can differ. To avoid this trouble, we use an auxiliary parameter κ, which has a sec. dimension to modify the fractional operator to have the same dimension for the sides. Equations (9) and (10) become

κα1CDtαS(t)=Υξ1S(t)I(t)+σA(t)+ψH(t)ξ2W(t)S(t)δS(t),κα1CDtαE(t)=ξ1I(t)+σA(t)+ψH(t)+ξ2W(t)S(t)ν+δE(t),κα1CDtαI(t)=νηE(t)β1+β2+δI(t),κα1CDtαA(t)=ν1ηE(t)ρ+δA(t),κα1CDtαH(t)=β1I(t)+ρA(t)β3+δH(t),κα1CDtαR(t)=β2I(t)+β3H(t)δR(t),κα1CDtαW(t)=θ1I(t)+θ2A(t)λW(t). (11)

Subject to non‐negative initial conditions

S(0)=S0,E(0)=E0,I(0)=I0,A(0)=A0,H(0)=H0,R(0)=R0,W(0)=W0. (12)

3.1. Equilibrium points and basic reproduction number

To find the disease‐free equilibrium of the suggested fractional‐order model (11), we solve the following system.

0=Υξ1S(t)I(t)+σA(t)+ψH(t)ξ2W(t)S(t)δS(t),0=ξ1I(t)+σA(t)+ψH(t)+ξ2W(t)S(t)ν+δE(t),0=νηE(t)β1+β2+δI(t),0=ν1ηE(t)ρ+δA(t),0=β1I(t)+ρA(t)β3+δH(t),0=β2I(t)+β3H(t)δR(t),0=θ1I(t)+θ2A(t)λW(t). (13)

We get P0=Υ/δ,0,0,0,0,0,0, which is the point where there is no disease. If the basic reproduction number R0>0, then the system (13) has a positive endemic equilibrium point, which is represented by

S=uxyzλν(λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2),E=xzδ3λ+xzδλ(eu+δβ3)+λνΥ(aδ+bcβ2+(bδσzη)β3xν(λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2),+β1(bδσdψ+bσβ3))ξ1+uνΥ(byθ2zηθ1)ξ2xν(λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2),I=η(xzδ3λ+xzδλ(eu+δβ3)+λνΥ(aδ+bcβ2+(bδσzη)β3xy(λ(vδ+guβ2+(uδσzη)β3+β1(uδσfψ+uσβ3))ξ1t(zηθ1uyθ2)ξ2),+β1(bδσdψ+bσβ3))ξ1+uνΥ(byθ2zηθ1)ξ2)xy(λ(vδ+guβ2+(uδσzη)β3+β1(uδσfψ+uσβ3))ξ1t(zηθ1uyθ2)ξ2),A=bνΥxzbuyδλλ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2,H=νΥ(dβ1bρ(δ+β2))uxyz+δλ(dβ1bρ(δ+β2))λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2,R=νΥ(zδηβ2+(debδρ)β3)uxyzδ+λ((bδρ+dβ1)β3+β2(zδη+dβ3))λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2,W=νΥ(zηθ1byθ2)xyzλ+uδ(zηθ1byθ2)λ(aδ+bcβ2+(bδσzη)β3+β1(bδσdψ+bσβ3))ξ1u(zηθ1byθ2)ξ2,

where x=δ+ν,y=δ+β1+β2,z=δ+ρ,u=δ+β3,a=ηz+bδσ+bρψ,b=η1,c=δσ+ρψ+σβ3,d=δη+ρ,e=β1+β2.

A vital indicator of the spread of infectious disease in the population is the basic reproduction number R0, defined as the number of new infections caused by a typical infectious person in a disease‐free equilibrium population. An epidemic will spread if R0>1. While that an outbreak will most likely not accrue if R0<1. To obtain R0 for the system (13), we use the generation method. 36 The infection components in the model system are E,  I,  A,  H, and W, so we consider the following fractional system:

κα1CDtαΦ(t)=FΦ(t)VΦ(t), (14)

where

FΦ(t)=κ1αξ1I(t)+σA(t)+ψH(t)S(t)+ξ2W(t)S(t)0000,

and

VΦ(t)=κ1αν+δE(t)νηE(t)+β1+β2+δI(t)ν1ηE(t)+ρ+δA(t)β1I(t)ρA(t)+β3+δH(t)θ1I(t)θ2A(t)+λW(t).

At point P 0, the Jacobian matrix for F and V is given by

JFP0=κ1αΥδ0ξ1ξ1σξ1ψξ200000000000000000000,

and

JVP0=κ1αν+δ0000νηβ1+β2+δ000ν(η1)0ρ+δ000β1ρβ3+δ00θ1θ20λ.

The basic reproduction number is given by the spectral radius of JFP0JVP01 as follows:

R0=ηνξ1Υδδ+νδ+β1+β2+Υξ2ηνθ1+1ηνδ+β1+β2θ2δλδ+νδ+β1+β2+Υ1ηνσξ1δδ+νδ+ρ+ψΥ(δη+ρβ1+(1η)ρ(δ+β2))ξ1δ(δ+ν)(δ+ρ)(δ+β1+β2)(δ+β3). (15)

3.2. Sensitivity analysis

The sensitivity analysis of a few parameters used in the proposed model (11) is discuss in this section. That will make it easier for us to identify the parameters that favorably impact the basic reproduction number. To do this, we apply the technic given in Tuan et al. and Rezapour et al. 11 , 26 Using R0, we have

θ1R0=ηνΥξ2δλ(δ+ν)(δ+β1+β2),ΥR0=R0Υ,θ2R0=(1η)νΥξ2δλ(δ+ν)(δ+ρ),ξ1R0=(1η)νσΥδ(δ+ν)(δ+ρ)+νΥS0ηδ+ρδ+β3+ρψ1ηδ+β2+ψβ1δη+ρδ(δ+ν)(δ+ρ)(δ+β1+β2)(δ+β3),ξ2R0=ηνΥθ1λδ(δ+ν)(δ+β1+β2)+(1η)νΥθ2λδ(δ+ν)(δ+ρ),σR0=(1η)νΥξ1δ(δ+ν)(δ+ρ),ψR0=νΥ(δη+ρβ1+(1η)ρ(δ+β2))ξ1δ(δ+ν)(δ+ρ)(δ+β1+β2)(δ+β3),νR0=Υξ1λψρ1ηδ+β2+β1δη+ρ+Υηδ+ρδ+β3λξ1+θ1ξ2λ(δ+ν)2(δ+ρ)(δ+β1+β2)(δ+β3)+(1η)Υ(λσξ1+θ2ξ2)λ(δ+ν)2(δ+ρ),λR0=ηνΥθ1ξ2δλ2δ+νδ+β1+β21ηνΥθ2ξ2δλ2δ+νδ+ρ,ρR0=1ηνΥλδδ+νδ+ρ2θ2ξ2δ+β3+β3σξ1λ+λδξ1σψλδ+β3,β1R0=ηνΥλξ1δ1ψψβ2+β3+θ1ξ2δ+β3δλ(δ+ν)(δ+β1+β2)2(δ+β3),β2R0=ηνΥλξ1δ+ψβ1+β3+θ1ξ2δ+β3λδ(δ+ν)(δ+β1+β2)2(δ+β3),β3R0=νΥψξ1δη+ρβ1+1ηρδ+β2δ(δ+ν)(δ+ρ)(δ+β1+β2)(δ+β3)2,ηR0=νΥδ+β3δ+ρθ1ξ2+λξ1δ+β1+β2θ2ξ2+λσξ1+ψξ1λρβ2+δρβ1δλ(δ+ν)(δ+ρ)(δ+β1+β2)(δ+β3),δR0=νΥδηθ1ξ2+λξ1λδ+νδ+β1+β21δ+ν+1δ+β1+β2+ρξ1ψ1η+β1+β2δδ+νδ+ρ2δ+β1+β2δ+β3+ρξ1ψ1η+β1+β2δδ+νδ+ρ2δ+β1+β2δ+β31δ+ν+1δ+β3+1δ+β1+β2+1ηθ2ξ2+λσξ1λδ+ρδ+ν1δ+ν+1δ+ρ.

Given all parameters are positive, then θ1R0>0, and if η < 1, we have ΥR0>0,θ2R0>0,ξ1R0>0,ξ2R0>0,σR0>0,ψR0>0,νR0>0,λR0<0,β2R0<0,β3R0<0,δR0<0,and, if addψ<σ,thenρR0<0.

Thus for η<1,R0 is decreasing with λ,  β 2, β 3, δ, ρ and increasing with θ 1, θ 2, ξ 1, ξ 2,  σ, ψ, ν,  Υ. Based on the result of derivatives, in general, cannot be commented on R0 sensitivity to other parameters β 1 and η, but for the parameter values in the proposed model, β1R0<0 and ηR0<0, thus R0 is decreasing with β 1 and η.

4. EXISTENCE AND UNIQUENESS ANALYSIS

In this section, we investigate the existence and uniqueness of the proposed model with the assistance of fixed‐point theory. First, let us write Equation (11) as follows:

κα1CDtαS(t)=χ1t,St,κα1CDtαE(t)=χ2t,E(t),κα1CDtαI(t)=χ3t,I(t),κα1CDtαA(t)=χ4t,At,κα1CDtαH(t)=χ5t,H(t),κα1CDtαR(t)=χ6t,R(t),κα1CDtαW(t)=χ7t,W(t), (16)

where

χ1t,S(t)=Υξ1S(t)I(t)+σA(t)+ψH(t)ξ2W(t)S(t)δS(t),χ2t,E(t)=ξ1I(t)+σA(t)+ψH(t)+ξ2W(t)S(t)ν+δE(t),χ3t,I(t)=νηE(t)β1+β2+δI(t),χ4t,At=ν1ηE(t)ρ+δA(t),χ5t,H(t)=β1I(t)+ρA(t)β3+δH(t),χ6t,R(t)=β2I(t)+β3H(t)δR(t),χ7t,W(t)=θ1I(t)+θ2A(t)λW(t).

By Lemma 3, the corresponding Volterra integral system of the second kind for Equation (16) is given by

St=S(0)+κ1αΓα0ttτα1χ1τ,Sτdτ,Et=E(0)+κ1αΓα0ttτα1χ2τ,Eτdτ,It=I(0)+κ1αΓα0ttτα1χ3τ,Iτdτ,At=A(0)+κ1αΓα0ttτα1χ4τ,Aτdτ,Ht=H(0)+κ1αΓα0ttτα1χ5τ,Hτdτ,Rt=R(0)+κ1αΓα0ttτα1χ6τ,Rτdτ,Wt=W(0)+κ1αΓα0ttτα1χ7τ,Wτdτ. (17)

Theorem 1

The kernel of the proposed fractional model will be satisfying the Lipchitz condition if the following inequality hold:

0Li<1,i=1,2,,7,

where L1=ξ1Z1+σZ2+ψZ3+ξ2Z4+δ,L2=ν+δ,L3=β1+β2+δ,L4=ρ+δ,L5=β3+δ,L6=δ, and L7=λ.

We will prove for the first kernel and similarly for the other. Consider function S(t) and S 1(t), then

χ1(t,S)χ1t,S1=ξ1It+σAt+ψHt+ξ2Wt+δStSt1ξ1It+σAt+ψHt+ξ2Wt+δStSt1ξ1Z1+σZ2+ψZ3+ξ2Z4+δStSt1=L1StSt1,

where Z1It,Z2At,Z3Ht, and Z4Wt.

Similarly, we get

χ2(t,E)χ2t,E1L2EtEt1χ3(t,I)χ3t,I1L3ItIt1χ4(t,A)χ1t,A1L4AtAt1χ5(t,H)χ5t,H1L5HtHt1χ6(t,R)χ6t,R1L6RtRt1χ7(t,W)χ7t,W1L7WtWt1.

By helping Equation (16), the proposed model Equation (11) can be written as follows:

κα1CDtαχ(t)=Ψt,χ(t),t[0,T],α(0,1], (18)

with initial condition    χ(0)=χ0, where χ(t)=S(t)E(t)I(t)A(t)H(t)R(t)W(t)T,χ0=S0E0I0A0H0R0W0T, and Ψt,χ=χ1(t,S)χ2(t,E)χ3(t,I)χ4(t,A)χ5(t,H)χ6(t,R)χ7(t,W)T.

Again, by Lemma 3, we have

χt=χ(0)+κ1αΓα0ttτα1Ψτ,χτdτ. (19)

Theorem 2

(Existence) Let T>0,χ0+7 and b > 0. Define

D:=t,χ(0,T,+7):t0,T,χχ0b,

and assume that Ψ:D+7 be a continuous function; furthermore, define ζ:=supt,χDΨt,χ(t) then, for α ∈ (0, 1], there exists a function χ[0,T],+7, which is a solution of Equation (18), where

T=minT.bΓα+1κ1αζ1α.

For χC0,T,+7, define norm of χ=supt[0,T]χt, with · a Banach space. Define the set V:=χC0,T,+7:χχ0b; it is evident that V is bounded, closed, and convex subset of the Banach space of all continuous function on C0,T,+7. It is clear that V is a non‐empty set, since χ 0 ∈ V. We now define an operator J on V. For each element χ ∈ V,

Jχt:=χ(0)+κ1αΓα0ttτα1Ψτ,χτdτ. (20)

Using that operator, Equation (19) can be written as χ=Jχ; now we must prove that J has a fixed‐point. This will be done by using Schuder's second fixed‐point theorem. First, we will show that JχV for χ ∈ V. For any χ ∈ V, we have

Jχ(t)χ(0)=κ1αΓα0ttτα1Ψτ,χτdτκ1αζΓα0ttτα1dτ=κ1αζΓα+1tακ1αζΓα+1Tα=κ1αζΓα+1bΓα+1κ1αζ=b. (21)

Hence, Jχχ0b, so JχV for χ ∈ V.

Second, we show that J is continuous. For every χn,χV,n=1,2,, with limnχnχ=0, we have limnχn(t)=χ(t),t[0,T], since all components of Ψt,χ(t) are continuous on , thus Ψ is continuous on χC0,T,+7:χχ0b, consequently,   limnΨt,χn(t)=Ψt,χ(t), so

supt0,TΨt,χn(t)Ψt,χ(t)0asn. (22)

On the other hand,

Jχn(t)Jχ(t)κ1αΓα0ttτα1Ψτ,χnτΨτ,χ(τ)dτκ1αΓαsupt0,TΨτ,χnτΨτ,χτ0ttτα1dτκ1αTαΓα+1supt[0,T]Ψτ,χnτΨτ,χτ0asn. (23)

Hence, JχnJχ0asn. Thus, J is continuous.

Finally, we have shown that J(V)=Jχ:χV is relatively compact. By the Arzela–Ascoli theorem, it is enough to demonstrate that J(V) is uniformly bounded and equicontinuous. Let yJ(V), for all t ∈ [0, T], we have

y(t)=Jχ(t)χ0+κ1αΓα0ttτα1Ψτ,χτdτ=χ0+κ1αζΓα+1tαχ0+κ1αζΓα+1Tα=χ0+b. (24)

Thus, Jχ(t)χ0+b, this means that J(V) is uniformly bounded. For any 0 ≤ t 1 ≤ t 2 ≤ T, we have

Jχt1Jχt2κ1αΓα0t1t1τα1Ψτ,χ(τ)dτ0t2t2τα1Ψτ,χτdτ=κ1αΓα0t1(t1τα1t2τα1)Ψτ,χτdτt1t2t2τα1Ψτ,χτdτκ1αΓα0t1t1τα1t2τα1Ψτ,χτdτ+t1t2t2τα1Ψτ,χτdτκ1αζΓα0t1t1τα1t2τα1dτ+t1t2t2τα1dτ.

Since α ≤ 1 and t 1 ≤ t 2, then t1τα1t2τα1; therefore,

Jχt1Jχt2κ1αζΓ(α)0t1t1τα1t2τα1dτ+t2t1αα=κ1αζΓα+1t2t1α+t1αt2α+t2t1α2κ1αζΓα+1t2t1α0ast2t1. (25)

Hence, Jχt1Jχt20ast2t1, and J(V) is equicontinuous on [0, T]. Thus, J(V) is relatively compact. Moreover, J has a fixed‐point, which is the required solution of Equation (18). This completes the proof. □

Remark 1

Assume hypotheses Theorem 1, the kernels χi,i=1,2,,7 satisfy Lipchitz condition; thus,

Ψt,χ(t)Ψt,χ(t)=maxt[0,T]χi(t)χi(t)maxt[0,T]L1S(t)S¯(t),L2E(t)Ē(t),L3I(t)Ī(t),L4A(t)Ā(t),L5H(t)H¯(t),L6R(t)R¯(t),L7W(t)W¯(t)maxL1,L2,,L7maxt[0,T]S(t)S¯(t),E(t)Ē(t),I(t)Ī(t),A(t)Ā(t),H(t)H¯(t),R(t)R¯(t),W(t)W¯(t)=LΨχ(t)χ(t),

where LΨ=maxL1,L2,L3,L4,L5,L6,L7 and Li,i=1,2,,7 as defined in Theorem 1. Thus, Ψ satisfies Lipchitz's condition.

Theorem 3

(Uniqueness) Assume all hypotheses in Theorems 1 and 2, the solution χC[0,T],+7 is unique, where

T<minT.bΓα+1κ1αζLΨ1α.

Suppose that χ(t)andχ(t) are solutions of Equation (18) on C0,T,+7, then

χ(t)χ(t)=κ1αΓα0ttτα1Ψτ,χτdτ0ttτα1Ψτ,χ¯(τ)dτκ1αΓα0ttτα1Ψτ,χτΨτ,χ¯(τ)dτ. (26)

By Lipchitz condition, we get

χ(t)χ(t)κ1αLΨΓα0ttτα1χτχτdτκ1αLΨΓαmaxt[0,T]χtχt0ttτα1dτ=κ1αLΨtαΓα+1maxt[0,T]χtχtκ1αLΨTαΓα+1maxt[0,T]χtχt=Cmaxt[0,T]χtχt, (27)

where C=κ1αLΨTαΓα+1(0,1).

On the other hand,

χ(t)χ(t)=maxt[0,T]χ(t)χ(t), (28)

this means that

maxt[0,T]χ(t)χ(t)Cmaxt[0,T]χ(t)χ(t). (29)

Thus, χtχt=0χt=χt. The solution is unique. □

5. NUMERICAL ALGORITHM

This section presents the numerical algorithm based on the predictor–corrector method. 37 Under the hypotheses of Theorem 2, there is a unique solution on [0, T]. Let t0=0<t1<<tN=T be a uniformly divide of the interval [0, T] where tn=nh,n=1,2,,N and h=T/N. By Lemma 3, the solution of

κα1CDtαS(t)=χ1t,S(t),

is equivalent to

S(t)=S(0)+κ1αΓ(α)0ttτα1χ1τ,S(τ)dτ. (30)

By Equation (30), we have

Stn+1=S(0)+κ1αΓ(α)0tn+1tn+1τα1χ1τ,S(τ)dτ. (31)

Let Sn+1Stn+1,n=0,1,2,,N1, by Lagrange interpolation, we approximate the kernel χ1t,S(t) over tk,tk+1 as follows:

χ1τ,S(τ)τtktk+1tkχ1tk+1,Sk+1+τtk+1tktk+1χ1tk,Sk. (32)

Substituting Equation (32) into Equation (31), we get

Sn+1=S0+κ1αΓ(α)k=0nχ1tk+1,Sk+1htktk+1τtktn+1τα1dτχ1tk,Skhtktk+1τtk+1tn+1τα1dτ=S0+κ1αΓ(α)k=0nχ1tk+1,Sk+1hααα+1n+1kα+1nkαnk+1+αχ1tk,Skhααα+1nkα+1n+1kαnkα. (33)

After the rearrangement of the summation on the right‐hand side of Equation (33), we get

Sn+1=S0+κ1αhαΓα+1χ1tn+1,Sn+1+k=0nCk,n+1χ1tk,Sk, (34)

where

Ck,n+1=nα+1(n+1)αnα,k=0,nk+2α+1+nkα2nk+1α+1,1kn.

The quantity S n + 1 on the right‐hand side of Equation (34) is predicted by Sn+1P applying the one‐step Adams–Bashforth method to Equation (31) by replacing the function χ1τ,S(τ) with the quantity χ1tk,Sk as follows:

Sk+1P=S0+κ1αΓ(α)k=0nχ1tk,Sktktk+1tn+1τα1dτ=S0+κ1αΓ(α)k=0nχ1tk,Sknk+1αnkα. (35)

Similarly, we can obtain the numerical algorithm of the other equation of system Equation (16). Thus, the approximate solution is given by

Sn+1=S0+κ1αhαΓα+1χ1tn+1,Sn+1P+k=0nCk,n+1χ1tk,Sk,En+1=E0+κ1αhαΓα+1χ2tn+1,En+1P+k=0nCk,n+1χ2tk,Ek,In+1=I0+κ1αhαΓα+1χ3tn+1,In+1P+k=0nCk,n+1χ3tk,Ik,An+1=A0+κ1αhαΓα+1χ4tn+1,An+1P+k=0nCk,n+1χ4tk,Ak,Hn+1=H0+κ1αhαΓα+1χ5tn+1,Hn+1P+k=0nCk,n+1χ5tk,Hk,Rn+1=R0+κ1αhαΓα+1χ6tn+1,Rn+1P+k=0nCk,n+1χ6tk,Rk,Wn+1=W0+κ1αhαΓα+1χ7tn+1,Wn+1P+k=0nCk,n+1χ7tk,Wk, (36)

and

Sn+1P=S0+κ1αΓ(α)k=0ndk,n+1χ1tk,Sk,En+1P=E0+κ1αΓ(α)k=0ndk,n+1χ2tk,Ek,In+1P=I0+κ1αΓ(α)k=0ndk,n+1χ3tk,Ik,An+1P=A0+κ1αΓ(α)k=0ndk,n+1χ4tk,Ak,Hn+1P=H0+κ1αΓ(α)k=0ndk,n+1χ5tk,Hk,Rn+1P=R0+κ1αΓ(α)k=0ndk,n+1χ6tk,Rk,Wn+1P=W0+κ1αΓ(α)k=0ndk,n+1χ7tk,Wk, (37)

where dk,n+1=nk+1αnkα.

6. STABILITY ANALYSIS OF ITERATION METHOD

Theorem 4

Assume the hypotheses of Theorem 1 and Sk,Ek,Ik,Ak,Hk,Rk,Wk,k=1,2,,n+1 are the solutions of systems Equations (36) and (37). Then, the fractional predictor‐corrector method Equations (36),and (37) is conditional stable.

Assume that S0,Sn+1,Sn+1P,n=0,1,2,,N1 have perturbations Š0,Šn+1,Šn+1P, respectively. Let μ0=max0nNŠ0+L1hακ1αd0,nΓα+1Š0 and ζ0=max0nNŠ0+L1hακ1αC0,nΓα+2Š0. Then,

Sn+1+Šn+1=S0+Š0+hακ1αΓα+2χ1tn+1,Sn+1P+Šn+1P+k=0nCk,n+1χ1tk,Sk+Šk, (38)
Sn+1P+Šn+1P=S0+Š0+hακ1αΓα+1k=0ndk,n+1χ1tk,Sk+Šk. (39)

Subtracting Equations (34) and (35) from Equations (38) and (39), respectively, then

Šn+1=Š0+hακ1αΓα+2χ1tn+1,Sn+1P+Šn+1Pχ1tn+1,Sn+1P+k=0nCk,n+1χ1tk,Sk+Škχ1tk,SkŠ0+hακ1αΓα+2χ1tn+1,Sn+1P+Šn+1Pχ1tn+1,Sn+1P+k=0nCk,n+1χ1tk,Sk+Škχ1tk,Sk (40)
Šn+1P=Š0+hακ1αΓα+1k=0ndk,n+1χ1tk,Sk+Škχ1tk,SkŠ0+hακ1αΓα+1k=0ndk,n+1χ1tk,Sk+Škχ1tk,Sk. (41)

By Lipchitz condition, we obtain

Šn+1ζ0+L1hακ1αΓα+2Šn+1P+k=0nCk,n+1Šk, (42)
Šn+1Pμ0+hακ1αΓα+1k=0ndk,n+1Šk. (43)

Substituting Equation (43) into Equation (42), we get

Šn+1ζ0+L1hακ1αΓα+2μ0+L1hακ1αΓα+2hακ1αΓα+1k=0ndk,n+1Šk+k=0nCk,n+1Šk=η0+L1hακ1αΓα+2k=0nhακ1αΓα+1dk,n+1+Ck,n+1Šk, (44)

where η0=ζ0+L1hακ1αΓα+2μ0. Using Lemma 1, we have

Šn+1η0+L1hακ1ααΓα+2k=0nnk+1α1Šk, (45)

where, α=max1,αα+121α, and by using Lemma 2, we get

Šn+1Cη0, (46)

where C is a positive constant. □

7. NUMERICAL RESULTS

7.1. Numerical simulation of the pandemic of COVID‐19 in the world

This subsection presents a computational simulation of the pandemic trend model of COVID‐19 in the world. To achieves that, we consider some of the literature's parameter values, and estimated the other parameter values, as in Table 1. According to the WHO, the birth rate in 2020 for the world was 18.077 per 1000 people, the death rate was 7.612 per 1000 people, and the total population on February 4, 2020, was N=7610105452. Thus, we have Υ=0.018077×N365=391,347.066 and δ=0.007612365=20.8547×106. The initial values of infected people, death or recovery people, and hospitalized people as stated in the report of the WHO on February 4, 2020, are I0=24545,R0=907, and H0=12627. 38 The initial values of A 0,  E 0, and W 0 assumed as A0=20000,E0=80000, and W0=50000. Since N=S0+E0+I0+A0+H0+R0, then S0=7609967373.

TABLE 1.

The numerical values of parameters

Parameter Value Source Parameter Value Source
ξ 1 2.6 ×  10−8 Tuan et al. 11 β 1 0.02 Tuan et al. 11
ξ 2 1 ×  10−9 Tuan et al. 11 β 2 0.009 Tuan et al. 11
σ 0.0001 Estimated β 3 0.0074 Estimated
ψ 0.00023 Estimated ρ 0.0075 Estimated
δ 20.85 ×  10−6 Tuan et al. 11 θ 1 1 ×  10−6 Tuan et al. 11
ν 0.000058 Tuan et al. 11 θ 2 1 ×  10−6 Tuan et al. 11
η 0.075 Tuan et al. 11 λ 0.01 Tuan et al. 11

Concerning the parameter values in Table 1, the basic reproduction number R0>1. That means that the pandemic will spread, and the equilibrium point of the model Equation (11) is positive. P0=(2.02×107,4.957×109,7.43×105,2.66×106,2.7×106,1.37×1010,3.4×102). All the approximate solutions are computed by using Wolfram Mathematica software with κ=0.99. The graphical solutions of fractional system Equation (11) in the interval [0, 250] have been described in Figures 1, 2, 3, where the unit of time is days. Figures 1, 2, 3 show that the results of the model converge to their equilibrium point for different fractional‐order derivatives and stable at that points. These figures indicate that the obtained plots have the same behavior pattern for different values of α=1,0.9,0.8,0.7,0.6.

FIGURE 1.

mma8057-fig-0001

Graphical approximate solutions of S(t) and E(t) for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

FIGURE 2.

mma8057-fig-0002

Graphical approximate solutions of I(t) and A(t) for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

FIGURE 3.

mma8057-fig-0003

Graphical approximate solutions of H(t),  R(t), and W(t) for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

7.2. Effect of parameters on the epidemic spread

The parameter values of the model play a significant role influences the spread of the epidemic. So, the single most effective way to restrict the spread of a disease is to create quarantine to decrease the mobility of individuals. If we choose the same parameter values and the same initial values of the classical model (see Fatima et al. 1 ) as in Table 2, then the basic reproduction number R0<1 where Υ=0.00181. Thus, we get the results shown in Figures 4, 5, 6. Comparing the results with Fatima et al, 1 we note that the behavior of graphic solutions is the same. Figure 4, 5, 6 show that all variables in the pandemic model will be decreased and hit zero, indicating the system's stability.

TABLE 2.

The numerical values of the parameters

Parameter Value Parameter Value
ξ 1 0.0026 β 1 0.014
ξ 2 0.001 β 2 0.004
σ 0.04 β 3 0.05
ψ 0.023 ρ 0.045
δ 0.09 θ 1 0.001
ν 0.022 θ 2 0.008
η 0.065 λ 0.033

FIGURE 4.

mma8057-fig-0004

Approximate solutions of S and E with parameters of Table 2 for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

FIGURE 5.

mma8057-fig-0005

Approximate solutions of I and A with parameters of Table 2 for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

FIGURE 6.

mma8057-fig-0006

Approximate solutions of H, R, W with parameters of Table 2 for different values of α=1,0.9,0.8,0.7,0.6 [Colour figure can be viewed at wileyonlinelibrary.com]

8. CONCLUSION

In this paper, modeling and studied the pandemic trend of COVID‐19 has been presented with fractional‐order derivative. Using the generation matrix method, the basic reproduction number is calculated that located whether the disease would persist or disappears from the population. The equilibrium points for this system are calculated, where the graphical solutions show that the results of the model converge to their equilibrium points. Based on the derivatives of the basic reproduction number, the sensitivity of the parameters was analyzed. The existence and uniqueness of the solution to the proposed model have been proven using the fixed‐point theorem and by helping of the Arzela–Ascoli theorem. The fractional proposed model is solved using the predictor–corrector method in the sense of Caputo derivative. Using some essential lemmas, we proved that this method is conditionally stable. The results indicate that the disease will continue where that the basic reproduction number R0>1. We selected the same parameter values and same initial conditions in the classical model 1 for comparing the results of the fractional model with the classical model. We noted that both models have the same behavior. Moreover, parameters played a very significant role in limiting disease outbreaks.

CONFLICT OF INTEREST

This work does not have any conflicts of interest

ACKNOWLEDGEMENT

The authors would like to thank the anonymous referees for their valuable comments and suggestions. Praveen Agarwal thanks the SERB (project TAR/2018/000001), DST (projects DST/INT/DAAD/P‐21/2019 and INT/RUS/RFBR/308), and NBHM (DAE) (project 02011/12/2020 NBHM (R.P)/RD II/7867) for their necessary support.

Agarwal P, Ramadan MA, Rageh AAM, Hadhoud AR. A fractional‐order mathematical model for analyzing the pandemic trend of COVID‐19. Math Meth Appl Sci. 2022;45(8):4625–4642. doi: 10.1002/mma.8057

Modeling and studied the pandemic trend of COVID‐19 has been presented with fractional‐order derivative. Using the generation matrix method, the basic reproduction number is calculated that located whether the disease would persist or disappears from the population. The equilibrium points for this system are calculated, where the graphical solutions show that the results of the model converge to their equilibrium points. Based on the derivatives of the basic reproduction number, the sensitivity of the parameters was analyzed. The existence and uniqueness of the solution to the proposed model have been proven using the fixed‐point theorem and by helping the Arzela–Ascoli theorem.

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