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. Author manuscript; available in PMC: 2023 Apr 14.
Published in final edited form as: Cell. 2022 Mar 4;185(8):1346–1355.e15. doi: 10.1016/j.cell.2022.02.026

Figure 4. Cryo-EM structure of a TMEM106B protofilament highlighting the key structural features.

Figure 4.

(A) Cryo-EM density (mesh) and atomic model (sticks) of a TMEM106B protofilament. (B) A disulfide bond between C214 and C253. (C) Polymorphic site T185S and glycosylated asparagine at N183. (D) Glycosylated N164, (E) N151, and (F) N145. See also Figures S4 and S5 and Table S2.