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. 2022 Mar 31;50(7):4200. doi: 10.1093/nar/gkac211

Retraction of ‘MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1’

PMCID: PMC9023252  PMID: 35357497

Nucleic Acids Research, Volume 37, Issue 22, 1 December 2009, Pages 7447–7454, https://doi.org/10.1093/nar/gkp768

In September 2021, a reader raised concerns about PCNA and CHK-1 Western-blot bands in Figures 1A and 4A, respectively. While the institution found insufficient evidence to move forward with an investigation in 2020, a detailed examination of the figures by the editors found evidence of inappropriate image manipulation. A consultant subsequently hired by the institution corroborated the findings. There may be additional issues beyond the ones reported here.

Collectively, these issues render the findings unreliable, and the conclusions may no longer be valid. The authors are also unable to provide the original data for inspection. The Editors are, therefore, retracting the article.


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