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(A) Uptake of coumarin 6/PLGA NPs, coumarin 6/HA-PLGA micelles and coumarin 6/HA-PLGA micelles combined with free HA. The nucleus was stained with DAPI (blue) and green represented coumarin 6 (bar = 50 µm). (B) Cytotoxicity of PTX/HA-PLGA micelles, PTX/PLGA NPs, and PTX solution against MSCs and C6 glioma cells. Cell viability was determined by MTT assay after incubation with PTX formulations for 72 h. (C) IC50 values of PTX formulations in MSCs and C6 cells (* p < 0.05).
