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Dysfunctional DAT activity in G2019S KI mice appears at 9 months of age. Kinetic analysis of [3H]-DA uptake in synaptosomes were performed in the striata of 6-month-old (A), 9-month-old (B), 12-month-old (C) and 18-month-old (D) G2019S KI mice versus age-matched WT controls. Data are expressed as mean ± SEM of n = 4 mice per group. Statistical analysis was performed using the Student t-test, two-tailed for unpaired data. * p < 0.05, different from WT mice.
