Table 2.
Comparison between patients with HRs to ICM and patients with HRs to GBCM.
| HRs 1 to ICM 2 | HRs to GBCM 3 | p-Value | ||
|---|---|---|---|---|
| Patients | (n°) | 278 | 65 | |
| Age (years) at the first evaluation | (median, ±SD) | 59 (±16) | 47 (±16) | <0.01 * |
| Total HRs | (n°, %) | 289 (79) † | 72 (20) † | N.S. * |
| IHRs | (n°, %) | 226 (77) † | 61 (21) † | N.S. * |
| NIHRs | (n°, %) | 63 (85) | 11 (15) | N.S. * |
| Comorbid allergic/hypersensitivity | ** | |||
| Allergic rhino-conjunctivitis | (n°, %) | 47 (16.7) | 15 (21.7) | N.S. |
| Angioedema | (n°, %) | 7 (2.5) | 1 (1.4) | N.S. |
| Asthma | (n°, %) | 15 (5.3) | 10 (14.5) | <0.05 |
| Contact allergy | (n°, %) | 17 (6) | 9 (13) | N.S. |
| Drug allergy | (n°, %) | 9 (3.2) | 2 (2.9) | N.S. |
| Food allergy | (n°, %) | 5 (1.8) | 6 (8.7) | <0.01 |
| Idiopathic anaphylaxis | (n°, %) | 1 (0.3) | - | - |
| Hymenoptera allergy | (n°, %) | 1 (0.3) | 1 (1.4) | N.S. |
| Mastocytosis | (n°, %) | 3 (1.1) | - | - |
| Non-allergic drug hypersensitivity | (n°, %) | 77 (27.4) | 32 (46.4) | <0.01 |
| Non-allergic food reactions | (n°, %) | 19 (6.8) | 5 (7.2) | N.S. |
| Urticaria | (n°, %) | 10 (3.5) | 6 (8.7) | N.S. |
| Urticaria + angioedema | (n°, %) | - | 1 (1.4) | - |
| Comorbid non-allergic diseases | ** | |||
| Autoimmunological disease | (n°, %) | 21 (7.5) | 6 (8.7) | N.S. |
| Cardiovascular/heart disease | (n°, %) | 78 (27.7) | 4 (5.8) | <0.01 |
| Gastrointestinal disease | (n°, %) | 64 (22.8) | 13 (18.8) | N.S. |
| Hematologic disease | (n°, %) | 10 (3.5) | 3 (4.3) | N.S. |
| History of cancer | (n°, %) | 159 (56.6) | 28 (40.6) | <0.05 |
| Neurologic disease | (n°, %) | 31 (11) | 16 (23.2) | <0.05 |
| Psychiatric disorder | (n°, %) | 21 (7.5) | 5 (10.1) | N.S. |
| Renal disease | (n°, %) | 7 (2.5) | 1 (1.4) | N.S. |
1: HRs = hypersensitivity reactions; 2: ICM = iodinated contrast media; 3: GBCM = gadolinium-based contrast media; *: Mann–Whitney U test; **: chi-square test; †: The sum of percentages does not include reactions to unknown contrast media.