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. 2022 Apr 22;51(1):61–69. doi: 10.1007/s15010-022-01822-x

Table 2.

Post-COVID symptoms and functional limitations according to each cluster

Cluster 0 (n = 432) Cluster 1 (n = 696) Cluster 2 (n = 841) P-value
Number of post-COVID symptoms 2.9 ± 1.15 2.6 ± 1.05 0.75 ± 0.85  < 0.001
Fatigue 420 (97.2%) 599 (86.1%) 187 (22.25%)  < 0.001
Dyspnea at rest 317 (73.4%) 131 (18.8%) 11 (1.3%)  < 0.001
Dyspnea at exertion 398 (92.1%) 513 (73.7%) 143 (17.0%)  < 0.001
Musculoskeletal pain (including headache) 255 (59.0%) 429 (61.6%) 203 (24.15%)  < 0.001
Memory loss 99 (22.9%) 176 (25.3%) 66 (7.85%)  < 0.001
Cognitive Blurring-frain fog 62 (14.35%) 87 (12.5%) 40 (4.75%)  < 0.001
Concentration loss 42 (9.7%) 73 (10.5%) 25 (3.0%)  < 0.001
Hair loss 90 (20.8%) 274 (39.4%) 106 (12.6%)  < 0.001
Palpitations-tachycardia 50 (11.6%) 59 (8.5%) 31 (3.7%)  < 0.001
Skin rashes 53 (12.3%) 123 (17.7%) 60 (7.1%)  < 0.001
Gastrointestinal Problems 41 (9.5%) 59 (8.5%) 33 (3.9%) 0.002
Diarrhea 7 (1.6%) 31 (4.45%) 11 (1.3%) 0.002
Voice Problems 6 (1.4%) 23 (3.3%) 6 (0.7%) 0.006
Ageusia 7 (1.6%) 36 (5.2%) 10 (1.2%)  < 0.001
Anosmia 12 (2.8%) 36 (5.2%) 32 (3.8%) 0.270
Ocular problems 41 (9.5%) 60 (8.6%) 15 (1.8%)  < 0.001
Throat pain 6 (1.4%) 29 (4.2%) 15 (1.8%) 0.023
Limitation occupational Activities 244 (56.5%) 153 (22.0%) 21 (2.5%)  < 0.001
Limitation leisure/social activities 398 (92.1%) 186 (26.7%) 20 (2.4%)  < 0.001
Limitation basic daily life activities 351 (81.25%) 22 (3.15%) 16 (1.9%)  < 0.001
Limitation instrumental daily life activities 403 (93.3%) 116 (16.7%) 23 (2.7%)  < 0.001
FIC symptoms (0–12) 6.6 ± 3.25 3.25 ± 1.85 0.7 ± 1.2  < 0.001
FIC disability (0–12) 5.4 ± 2.7 0.9 ± 1.2 0.1 ± 0.5  < 0.001
HADS-A (0–21) 7.35 ± 5.7 5.9 ± 4.9 2.75 ± 4.45  < 0.001
HADS-D (0–21) 7.95 ± 5.35 5.45 ± 4.3 2.4 ± 3.65  < 0.001
Sleep quality (0–21) 8.35 ± 4.35 7.7 ± 3.9 4.55 ± 2.85  < 0.001

FIC, functional impairment checklist; HADS, Hospital Anxiety and Depression Scale (A: anxiety; D: depression)