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. Author manuscript; available in PMC: 2022 Apr 25.
Published in final edited form as: Immunohorizons. 2021 Oct 26;5(10):844–854. doi: 10.4049/immunohorizons.2100070

FIGURE 4. Mortality in EAE mice is associated with elevated inflammation.

FIGURE 4.

C57BL/6 mice were immunized with MOG35–55 to induce EAE. EAE and age-matched nonimmunized (non-EAE) mice under went CLP 35 d after EAE induction. Plasma cytokines were assessed prior to and 12 h post–CLP surgery in non-EAE, EAE mice that survived CLP-induced sepsis, and EAE mice that succumbed to CLP-induced sepsis. Plasma IL-6 (A and B) and IL-10 (C and D) prior to (A) and (C) and 12 h post– (B) and (D) CLP surgery in non-EAE, EAE mice that survived CLP-induced sepsis, and EAE mice that succumbed to CLP-induced sepsis. Gray dashed lines indicate the upper limit of detection (ULOD) and lower limit of detection (LLOD) for the respective ELISA plate. Samples are combined from two independent experiments run on single ELISA plates with five to eight mice per group. Error bars represent SEM. *p < 0.05.