Figure 6.

A combination of MLT and Andro synergistically inhibit patient-derived tumor organoid growth. (A) Microscopic images of patient-derived tumor organoids derived from two patients cultured in each treatment group (20× magnification); the organoid count analysis are shown in the right panel. (B) Representative images of LC3B expression in the extracts of organoids in each treatment group by western blot analysis. The ratios of LC3-II to LC3-I based on the quantification of the bands in the immunoblot were shown in the lower panel. (C) Representative images of NR4A1, ATG12 and CTSL expression in the extracts of organoids in each treatment group by western blot analysis. Statistical significance: ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.