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. 2020 Jul 29;10(47):28213–28224. doi: 10.1039/d0ra05405d

Optical properties of 3-substituted indoles†

Jagdeep Kumar 1, Naresh Kumar 1, Prasanta Kumar Hota 1,✉
PMCID: PMC9055839  PMID: 35519093

Abstract

The optical properties of various donor or acceptor p-phenyl substituted ethenyl indoles were studied in solvents of varying polarity using absorption, fluorescence and TDDFT methods. Ethenyl indole exhibits non-linear optical properties (NLO) in a substituent dependent manner. Compound with a strong electron-attracting substituent, shows large NLO properties with charge transfer behavior, whereas ethenyls with moderate electron withdrawing or electron donating substituent exhibit lower NLO properties with non polar excited state. A highly dipolar excited state for p-nitro phenyl substituted ethenyl indoles (μe: 18.2–27.1 debye; Δμ: 9.4–17.8 debye) is observed as compared to other ethenyls (μe: 6.6–9.5 debye; Δμ: 4.2–6.2 debye). From TDDFT study, it is shown that the HOMO–LUMO energy of ethenyl is increased with increasing the electron donating ability of the p-phenyl substitution. The optical band gap of ethenyl 3 without substitution, is decreased upon p-phenyl substitution either with an electron withdrawing (Cl, NO2) or an electron donating (OCH3, OH, NH2) substituent. The compound with a strong electron accepting, p-nitrophenyl ethenyl indole 1 shows 12 times better NLO response as compared to the reference ethenyl indole 3 (β: 1: 115 × 10−30 esu−1 cm5, 3: 9 × 10−30 esu−1 cm5). Ethenyls 2–6 bearing a weak or moderately electron withdrawing or electron accepting substituent, exhibit lower NLO response. The β of ethenyl is increased with increasing the order of electron withdrawing nature of phenyl ring. Overall, a correlation of β with the optical band gap, ground state dipole moment, % of charge transfer in the ground and excited state is found.

Various donor and acceptor p-phenyl substituted ethenyl indoles were synthesized and studied their optical properties in solvents of varying polarity using absorption, fluorescence and TDDFT methods.graphic file with name d0ra05405d-ga.jpg

1. Introduction

Donor–acceptor substituted conjugated molecules have a wide range of applications in chemistry, biology1–6 and organic electronics7,8 like photoswitches,9–12 organic light-emitting diodes (OLEDS),13,14 dye-sensitized solar cell (DSSC),15–25 nonlinear optics (NLO).7,13,14,26–37 In particular, NLO materials with varied shape and size (e.g. dipolar, quadrupolar, octupolar) were developed and extensively studied using various testing methods such as electric field induced second harmonic (EFISH) generation, hyper Rayleigh scattering (HRS),26–37 solvatochromic methods38–46 and computational based density functional theory (DFT).39,42 Among all the methods, the solvatochromic method is most suitable, easy and cost effective method, in which the NLO response, first hyperpolarizability coefficient (β) of small dipolar molecule can be obtained accurately.38–46 The large second order NLO response, first hyperpolarizability can be achieved through extended conjugation as well as by tuning the donor–acceptor length in electron donor–acceptor substituted molecule.7,8 NLO response of 6-substituted indole derivatives were tested previously.47,48 These includes indole with tricyano furan acceptor based conjugated molecules and studied their thermal and electro-optic properties. It is shown that indole can act as a donor in developing nonlinear optical material. In such system, increasing the electron donating ability of indole moiety leads to decrease in thermal stability and increased in NLO responsive electro-optical properties.47 Similarly, as compared to aniline, the 6-(pyrrolidin-1-yl)-1H-indole based donor system exhibits enhance in its macro NLO response electro-optic properties.48 In such system, the NLO properties is increased with increasing the electron donating ability of indole moiety. This could be due to favorable intermolecular dipole interaction forces.49 In comparison to earlier report, the 3-substituted indole derivatives are more sensitive to medium polarity due to (i) the formation of stable resonating structure at indolyl-3-position and (ii) the donating ability of indole moiety can also be tuned through various N-substitution.50,51

The advantage of these molecules is due to their substituent induced varied optical properties such as absorption, fluorescence, extinction coefficient, HOMO–LUMO energy gap, excited state dipole moment and transition energy, which provide most valuable information in designing future molecules. In order to gain more insight into the NLO response of 3-substituted indole based conjugated molecules, we have studied the substituent dependent first hyperpolarizability (β) of various electron donor/acceptor substituted p-phenyl and N-substituted ethenyl indoles (1–9) using solvatochromic method. The ethenyls (1–9) with varied electron withdrawing and donating p-phenyl substitution (NO2, Cl, H, OCH3, OH, NH2, N–SO2C6H5, N–COCH3, N–Et) were synthesized (Scheme 1) and the effect of substitution on the optical properties of indole compounds were evaluated.

Scheme 1. Structure of indole compounds 1–9.

Scheme 1

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The excited state of nitro substituted ethenyls (1, 7, 8, 9) is highly dipolar and exhibit charge transfer excited state. A higher β value is found for these ethenyls bearing a strong electron withdrawing substituent. On the other hand, excited state of compounds 2–6 is non-polar and exhibit a lower β value. Overall, the 2nd order NLO properties is proportional to the ground state dipole moment, polarizability, ionic character and % of charge separation in the molecule. On the other hand, β value is inversely proportional to the optical band gap of the ethenyl indole. The above substituent dependent studies on p-phenyl and N-substituted ethenyl indole provide most valuable information in understanding the optical properties in conjugated molecules.

2. Experimental section

2.1. Materials and analytical equipments

The starting materials and reagents for the synthesis of ethenyl indoles were purchased from the local suppliers (Ms E. Merck, Sisco Research Laboratory, Sigma-Aldrich). UV grade solvents are used for spectroscopy study. Compounds are synthesized using Carousel 6 plus reaction station, Radleys make. Synthetic compounds are characterized by 1H and 13C nuclear magnetic resonance (NMR), Fourier-transform infrared (FTIR), mass spectrometry (MS) using electron impact (EI) method and carbon, hydrogen, nitrogen and sulfur (CHNS) analysis. The absorption spectra are recorded on a PerkinElmer Lambda 25 UV-Vis and Lambda 750 UV/VIS/near infrared (NIR) spectrophotometer. The fluorescence spectra are recorded on a PerkinElmer LS-55 fluorescence spectrophotometer using a red photomultiplier tubes (PMT) detector system. FTIR spectra are recorded on a Impact Nicolet-400 spectrophotometer using KBr discs. The 1H and 13C NMR spectra are recorded on a JEOL 500 MHz FTNMR instrument in CDCl3 as solvent and using tetramethylsilane (TMS) as an internal standard. MS spectra are measured on a GCD 1800A Hewlett Packard gas chromatography (GC)–mass spectrometer. CHNS analyses are recorded on a Theoquest CE instrument 1112 series CHNS auto analyzer. Melting points are recorded on a Lab India make melting point apparatus.

2.2. Synthesis of compounds 1–9

The substituted p-phenyl ethenyl-E-indoles (1–5) are synthesized through condensation of 2 molar ratio of p-substituted phenyl acetic acid with respect to 3-formylindole in pyridine–piperidine mixture as described earlier6,45,46,50,51 and the routes are shown in Scheme 2, e.g. for obtaining compound 1, the typical synthetic protocol is as follows: 2-formyl indole (1.45 g, 0.01 M) is taken with p-nitrophenyl acetic acid (3.62 g, 0.02 mol) along with in freshly distilled pyridine (10 mL) and piperidine (0.6 mL) in a round bottom flask. The reaction mixture was refluxed at 100 °C for six hours. The progress of the reaction is monitored by thin layer chromatography (TLC). After cooling the reaction mixture, the excess of pyridine was remove from the reaction mixture by treating with 100 mL of diluted hydrochloric acid. A red colored product is collected after extracting the crude product in dichloromethane. The product was further purified by column chromatography using 2% ethyl acetate in petroleum ether as the eluting solvent. The yield of the desired compound is obtained in 31%. Similarly, compounds 2–5 were obtained with yield 56%, 45%, 34% and 33% respectively. Compound 6 was prepared with 47% yield through reduction reaction of 1. For this purpose, the alcoholic solution of ethenyl indole 1 (0.2 g, 0.001 M) is refluxed in ferrous sulfate (1.5 g, 0.01 M) and aqueous ammonia solution at 100 °C for 3 h. Compound 7 was obtained with 80% yield through N-alkylation of compound 1 (0.5 g, 0.002 M) with ethyl bromide (2 mL, 0.01 mol) in presence of potassium-t-butoxide (0.2 g, 0.002 M) and t-butyl alcohol (20 mL).52 Compound 8 was obtained with 83% yield through N-acetylation of compound 1 (0.1 g, 0.0004 M) using acetic anhydride (10 mL) in presence of sodium acetate (0.1 g, 0.0012 M).53 Compound 9 was obtained with 80% yield through N-sulphonation of compound 1 (0.2 g, 0.001 M) using benzene sulphonyl chloride (1 mL, 0.01 M) and potassium carbonate (1.0 g, 0.01 M) in acetone54 as shown in Scheme 2. The products are purified by column chromatography using 2–5% ethyl acetate in petroleum ether (60–80 °C) as the eluting solvent. The characterization of compounds were carried out satisfactory using 1H and 13C NMR, MS, FTIR, CHNS analysis.

Scheme 2. Synthetic routes and reaction conditions for obtaining indole compounds, (a) pyridine, piperidine, 100 °C, reflux, 6 h; (b) FeSO4, aqu. NH3, ethanol, 100 °C, 3 h; (c) ethyl bromide, potassium-t-butoxide, t-butyl alcohol, reflux, 4 h; (d) acetic anhydride, sodium acetate, reflux, 1 h; (e) benzene sulphonyl chloride, potassium carbonate, acetone, 0 °C, 2 h.

Scheme 2

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2.3. Absorption and fluorescence studies

For all absorption and fluorescence measurements, UV grade solvents were used. For absorption, (1–4) × 10−5 M solution and for fluorescence studies, 0.5 × 10−5 M solution of compounds were prepared in different solvents and recorded using a 1 cm × 1 cm, light path length quartz cuvette. Fluorescence spectra were recorded by exciting the sample at their absorption maximum (λabs max). The ground and excited state energy (E) of the compounds are calculated using absorption wavelength (λabs max), fluorescence wavelength (λem max) maximum and eqn (1). Where,

Eabs = (hc/λabs max) = (1.24/λabs max) (in KeV) 1a
Eem = (hc/λem max)= (1.24/λem max) (in Kev) 1b

The energy band gap (ΔE) of 1–9 is obtained from the intersection of excitation and fluorescence spectrum, Tauc plot and TDDFT computation method.

2.4. Dipole moment calculation

Change of excited state dipole moment of compounds is calculated using McRay eqn (2).41,55

νabs − νem = (δabs + δem) + {(2Δμ2/hca3)F(ε,n)} = constant + mF(ε,n) 2

F(ε,n) = [(ε − 1)/(ε + 2) − (n2 − 1)/(n2 + 2)], m = (2Δμ2/hca3)where, νabs is absorption maximum wave number, νem fluorescence maximum wave number, νabs − νem is the Stokes' shift, δabs and δem are difference in vibrational energy of molecule (in cm−1) in excited and ground state for absorption and emission respectively, μe and μg are the excited state and ground state dipole moments respectively, μe − μg = Δμ is the change in dipole moment, h is the Planck constant (6.62 × 10−34 joule s), c is the velocity of light in vacuum (3 × 108 meter per s), ε is the relative permittivity (i.e. dielectric constant) and n is the refractive index of the solvent.56,57 The Onsagar cavity radius (a) can be calculated using eqn (3) as described elsewhere.58

a = (3M/4πδN)1/3, 3

where, M = molecular weight of molecule, N = Avogadro number = 6.022 × 1023, δ = molecular density of molecule.

2.5. First hyperpolarizability calculation

The first hyperpolarizability coefficient (β) is related to second order nonlinear optical (NLO) properties of molecule. The solvatochromism method is used to obtain β in methanol using Oudar formula59 as reported elsewhere38–44 using eqn (4) and eqn (5).

(β) = (3/2h2c2) × {(vabs)2(rg)2(Δμ)}/{(vabs2 − v2)(vabs2 − 4v2)} 4

where, vabs: absorption maximum wave number and; v: incident reference wave number, 1064 nm of Nd:YAG laser source to which the β value is referred;

The transition dipole moment (rg) is calculated using eqn (5).

(rg)2 = [(3e2h)/(8π2mc)] × (f/vabs) = 2.13 × 10−30 × (f/vabs) 5

where, f is the Oscillator strength, Inline graphic, which is obtained from the plot, molar absorption coefficient (ε) vs. wave number (ν).60

2.6. Computed parameters using time dependent density functional theory (TDDFT)

For computational calculation, the Orca quantum chemical software package61–63 with time dependent density functional theory (TDDFT)64–66 is used. The ground state dipole moment, absorption wavelength, the vertical excitation energy, oscillator strength of the optimized ethenyls were obtained using B3LYP functional with a def2 SVP basis set.67

3. Results and discussion

3.1. Synthesis

The trans-olefins of 1–9 were obtained through condensation reaction as shown in Scheme 2 with reasonable yield (31–83%). Overall the yield of reaction is obtained satisfactory. All the compounds were characterized through 1H NMR, 13C NMR, FTIR, MS (EI + method) and CHN analysis. In 1H NMR, the two doublet peaks correspond to trans olefin protons of compound 1–9 appear near δ 7.2 and δ 7.4 (each of 1H, J = 15.8–16.5 Hz). Similarly, multiplate peaks near δ 7.1–7.2 (2H, m –C5–H, C6–H), one singlet peak near δ 7.3–7.4 (1H, s, –C2–H), two doublet peaks near δ 7.9 (1H, d, J = 7.5–8.2 Hz, –C4–H) and δ 8.0 (1H, J = 6.2–7.5 Hz, –C7–H) correspond to the indole ring protons. In FTIR, the indole N–Hst is identified near 3370 cm−1. The C–Hst appear near 3040 cm−1, C Created by potrace 1.16, written by Peter Selinger 2001-2019 Cst near 1620 cm−1. Similarly, four peaks correspond to the C Created by potrace 1.16, written by Peter Selinger 2001-2019 Cst and C–Cst of phenyl ring are observed near 1520 cm−1, 1488 cm−1, 1455 cm−1, 1400 cm−1. For compound 1, the symmetrical and asymmetrical stretching frequency of nitro group is confirmed at 1330 cm−1 and 1520 cm−1. In compound 4, the methoxy, O–Cst is confirmed at 1244 cm−1. For compound 6, two sharp peaks at 3394 cm−1 and 3341 cm−1 are confirmed as primary amine NHst. For compound 7–9, the NHst peaks are disappeared upon N-substitution. For 8, the C Created by potrace 1.16, written by Peter Selinger 2001-2019 O stretching peak at 1703 cm−1 correspond to N-acetyl group and for 9, the S Created by potrace 1.16, written by Peter Selinger 2001-2019 O stretching appears at 1180 cm−1. Thus, olefins bearing indole heterocyclic unit and indole N-substituted ethenyls were synthesized using mild reaction condition and characterized successfully. The detail of characterization data is shown in ESI.†

3.2. Absorption and fluorescence studies of indole compounds 1–9

The absorption and fluorescence data of compounds 1–9 in different solvents of varying polarity are summarized in Table 1. From the absorption (Fig. 1 and S1a-i†) and fluorescence spectra (Fig. 2 and S2a-i†), it is shown that the absorption coefficient of ethenyl indoles (1–9) is in between 10 800–23 900 M−1 cm−1 (Table 2). On increasing the solvent polarity, the absorption and fluorescence wavelength maximum are red shifted. This suggest, a π–π* nature of electronic transition. On increasing the solvent polarity from n-hexane to dimethylformamide (DMF), the absorption maximum (λabs max) is moderately red shifted by 24 nm, 29 nm, 22 nm, 17 nm and 13 nm respectively for strong electron withdrawing nitro ethenyls (1, 7–9) and for strong electron donating amino compound 6. The λabs max of compound 5 with phenolic group is also moderately red shifted by 11 nm from n-hexane to polar solvent, DMF. On the other hand, the λabs max of other ethenyls 2–4 (Cl, H, OCH3) is not much sensitive to solvent polarity and a red shift of 0–5 nm is observed. In contrast to λabs max, the fluorescence maximum (λem max) is significantly red shifted by 151 nm, 133 nm, 172 nm, 202 nm for 1, 7–9 respectively from n-hexane to DMF. For 2–6, λem max is moderately red shifted by 14 nm, 20 nm, 22 nm, 09 nm and 11 nm respectively. This suggest the drastic stabilization of the excited state of 1, 7–9 due to coulomb interaction between the dipolar solute and solvent molecules.68,69 A red-shifted λem max in ethenyl indole (1, 7–9) is due to the electron delocalization from the indole moiety-to-the electron acceptor nitro group. As the transition is π → π* nature, the more stabilization of excited state with respect to the ground state leads to a red shifted in absorption and fluorescence wavelength. From the correlation of Hammett substituent constant,70 it is shown that strong electron acceptor –NO2 group (σp +0.81, for 1, 7–9) at the p-phenyl ring induces large electron delocalization in the excited state as compared to the weak electron acceptor chloro group –Cl (σp +0.24, in case of 2), –H (σp 0.0 in case of 3) and weak electron donor methoxy group –OCH3, (σp −0.28, in case of 4).

UV-Vis absorption and fluorescence data of 1–9 in different solvents.

Solvents λ abs max (nm) ε (M−1 cm−1) λ em max (nm) λ ex max (nm) Stokes' shift (va − vf) nm (cm−1) Quantum yield Φf
1 n-Hexane 403 15 423 497 408 94 (4693) 0.0104
1,4-Dioxan 407 21 011 554 372 147 (6520) 0.0216
THF 416 22 603 607 443 191 (7564) 0.0418
MeOH 413 23 900 590 370 177 (7264) 0.0013
AcCN 411 24 924 642 380 231 (8754) 0.0118
DMF 427 17 068 648 446 221 (7987) 0.0052
2 n-Hexane 338 17 900 384 351 46 (3544) 0.0026
1,4-Dioxan 336 14 750 388 341 52 (3988) 0.0037
THF 333 18 600 387 345 54 (4191) 0.0020
MeOH 335 18 800 395 354 60 (4534) 0.0016
AcCN 340 19 475 396 355 56 (4159) 0.0015
DMF 338 18 075 398 350 60 (4460) 0.0024
3 n-Hexane 328 4675 384 335 56 (4446) 0.0066
1,4-Dioxan 329 14 575 384 325 55 (4354) —
THF 331 14 200 397 347 66 (5023) 0.0083
MeOH 327 10 800 396 323 69 (5329) 0.0072
AcCN 325 14 925 407 333 82 (6199) —
DMF 332 14 975 404 346 72 (5368) 0.0110
4 n-Hexane 328 15 496 389 340 61 (4781) 0.0027
1,4-Dioxan 330 18 229 397 329 67 (5115) 0.0209
THF 331 17 101 403 324 72 (5398) 0.0163
MeOH 327 17 800 404 344 77 (5829) 0.0137
AcCN 326 15 020 409 349 83 (6225) 0.0176
DMF 333 18 530 411 349 78 (5700) 0.0196
5 n-Hexane 310 14 987 389 308 79 (6552) 0.0114
1,4-Dioxan 318 18 333 384 330 66 (5405) 0.0035
THF 319 21 754 385 332 66 (5373) 0.0058
MeOH 322 24 400 390 330 68 (5414) 0.0030
AcCN 323 16 741 395 335 72 (5643) 0.0042
DMF 331 15 588 398 347 67 (5086) 0.0081
6 n-Hexane 320 8467 389 333 69 (5544) 0.0361
1,4-Dioxan 324 14 522 394 354 70 (5484) 0.0041
THF 325 2989 397 355 72 (5581) 0.0334
MeOH 324 12 200 405 339 81 (6173) 0.0301
AcCN 325 12 814 397 337 72 (5581) 0.0745
DMF 333 12 185 400 365 67 (5030) 0.0056
7 n-Hexane 402 24 026 508 395 106 (5190) 0.0005
1,4-Dioxan 415 27 090 566 406 151 (6429) 0.0006
THF 420 23 141 590 420 170 (6860) 0.0007
MeOH 415 22 823 556 417 141 (6111) 0.0006
AcCN 419 21 238 649 415 230 (8482) 0.0008
DMF 430 27 318 640 426 210 (7630) 0.0007
8 n-Hexane 362 13 975 423 363 61 (3984) 0.0003
1,4-Dioxan 378 12 655 533 370 155 (7694) 0.0007
THF 375 11 800 537 375 162 (8045) 0.0008
MeOH 375 11 464 564 374 189 (8936) 0.0009
AcCN 376 10 900 602 374 226 (9984) 0.0010
DMF 382 11 200 592 380 220 (9287) 0.0009
9 n-Hexane 360 26 722 403 356 43 (3197) 0.0003
1,4-Dioxan 369 27 742 529 371 160 (8196) 0.0008
THF 374 16 773 576 377 202 (9376) 0.0008
MeOH 370 20 000 588 371 218 (10 020) 0.0009
AcCN 369 14 065 593 370 224 (10 236) 0.0010
DMF 377 14 178 605 369 228 (9996) 0.0009
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Fig. 1. Absorption spectra of 1–9 in methanol.

Fig. 1

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Fig. 2. Fluorescence spectra of 1–9 (0.5 × 10−5 M) in methanol.

Fig. 2

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Comparison of absorption wavelength maximum (λabs max), fluorescence wavelength maximum (λem max), extinction coefficient, oscillator strength (f), S0–S1 transition state energy (ΔE, eV), transient dipole moment between ground and excited states (rg), change of excited state dipole moment (Δμ), optical band gap (ΔE), first hyperpolarizability (β) of ethenyl indoles 1–9 in methanola.

λ abs max (nm) λ em max (nm) (ε) (M−1 cm−1) f S0–S1 (ΔE) (eV) (rg) debye (Δμ) debye (μe) debye (β) (in 10−30) esu−1 cm5
1 413 590 23 900 0.69 2.50 7.79 9.86 18.25 115
2 335 395 18 800 0.57 3.34 6.37 5.52 9.51 20
3 327 396 10 800 0.34 3.41 4.86 5.19 7.76 9
4 327 404 17 800 0.58 3.40 6.35 5.77 6.82 17
5 322 390 24 400 0.81 3.40 7.45 6.29 7.66 24
6 324 405 12 200 0.44 3.34 5.51 4.18 6.62 9
7 418 558 22 823 0.61 2.47 7.36 9.44 18.38 106
8 374 563 11 464 0.32 2.83 5.03 14.21 18.55 43
9 370 588 20 000 0.56 2.87 6.64 17.78 27.10 90
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a

Onsagar cavity radius “a” (in Å); 1: 4.53; 2: 4.47; 3: 4.38; 4: 4.55; 5: 4.43; 6: 4.45; 7: 4.74; 8: 4.75; 9: 5.12; ground state dipole moment μg (in debye): 1: 8.39; 2: 3.99; 3: 2.57; 4: 1.05; 5: 1.37; 6: 2.44; 7: 8.94; 8: 4.34; 9: 9.32; excited state dipole moment μe = Δμ(McRay method) + μ(TDDFT)g.

The singlet state energy of 1–9 is calculated from their absorption and fluorescence wavelength maximum (Table 2). The first singlet excited state energy band gap for 1, 7–9 is 2.47–2.87 eV, whereas it is 3.34–3.40 eV for 2–6. As per Tauc plot and TDDFT calculation, the order is 3 > 2 > 9 > 8 > 1 > 2 and 3 > 4 = 5 > 6 (Fig. S3†). The optical band gap of 1 and 7–9 is 0.70–0.94 eV lower than compound 2–6. Interestingly, indole is acting as a strong electron donor in presence of an electron withdrawing p-phenyl nitro substituent (for 1, 7–9), whereas indole acts as a weak electron acceptor in presence of an electron donating p-phenyl methoxy and amine (OCH3, NH2) substituent. In order to understand the effect of substituent and solvent polarity on the excited state, McRay plot, the Stokes' shift (va − vf) vs. solvent polarity parameter, F(ε,n) is drawn, (Fig. 3) for 1–9 and the excited state dipole moment is calculated (Tables 2 and S1†). For all compounds, the Stokes' shift values are increased linearly with increasing the solvent polarity. This further improved by the deletion of two solvents, 1,4-dioxan and acetonitrile. In order to get a good correlation factor, these two solvents were excluded from our calculation and the following correlation are obtained (1: m1 = 4245, R = 0.91; 2: m1 = 1384, R = 0.99; 3: m1 = 1304, R = 0.99; 4: m1 = 1434, R = 0.99; 5: m1 = −1847, R = 0.92; 6: m1 = 805, R = 0.85; 7: m1 = 3397, R = 0.92, 8: m1 = 7645, R = 0.97, 9: m1 = 9563, R = 0.95). It is shown that a large change in the excited state dipole moment is observed for 1, 7, 8 and 9 (9.44–17.78 debye) as compared to 2, 3, 4, 5 and 6 (4.18–6.29 debye). Similarly, the ground state dipole moment (μg) is computed for 1–9 using TDDFT. The μg for 2–6 is in between 1.05–3.99 debye, whereas μg for 1, 7, 8, 9 is 4.34–9.32 debye (Table S1†). Thus, the large solvatochromic shift in 1 and 7–9 is due to charge transfer excited state. On the other hand, ethenyl indoles 2–6 with a weak electron acceptor or donor group (–Cl, –H, –OCH3, –OH, –NH2) show small change in excited state dipole moment (4.18–6.29 D) and exhibit non polar excited state as compared to 1 and 7–9.

Fig. 3. McRay plot, Stokes' shift vs. F(ε,n) of 1–9. Solvents used are n-hexane, 1,4-dioxane, THF, MeOH, AcCN and DMF.

Fig. 3

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From Kamlet–Taft plot71 (Fig. 4 and Table S1†), it is shown that nitro compounds (1, 7–9) are highly polarized in the excited state. A large slope is observed for 1 and 7–9 as compared to 2–6 (slope: −5.14 × 10−3, R = 0.98 for 1; −0.93 × 10−3, R = 0.85 for 2; −1.32 × 10−3, R = 0.99 for 3; slope −1.43 × 10−3, R = 0.99 for 4; slope −2.69 × 10−3, R = 0.91 for 5; slope −0.71 × 10−3, R = 0.96 for 6; −4.03 × 10−3, R = 0.94 for 7; −7.38 × 10−3, R = 0.98 for 8; −9.22 × 10−3, R = 0.97 for 9). The formation of charge transfer excited state in 1 and 7–9 could be due to twist over the single bond attached to the p-phenyl ring and such phenomena is also suggested in other donor–acceptor substituted ethenyl systems.45,46,72–79

Fig. 4. Kamlet–Taft plot, emission wave number vs. solvent polarizability parameter π* of 1–9 in solvents, n-hexane, 1,4-dioxane, THF, MeOH, AcCN and DMF.

Fig. 4

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3.3. Time dependent density functional theory (TDDFT) studies

The geometry of the molecules are optimized and the parameters such as absorption, oscillator strength, HOMO–LUMO energy, optical band gap is computed for 1–9 using TDDFT method (Table S2†). The parameters obtained through computation methods are also followed the similar trend as compared to the experimental results. Compound with strong electron withdrawing p-phenyl substituent, the ground and excited states are stabilized, whereas, the ground and excited state are destabilized in presence of electron donating substituent compared to the unsubstituted ethenyl indole 3. This is due to the pushing or pulling of π electrons from indole to the p-phenyl substituted ring, which leads to the stabilization or destabilization of the ground or excited state.

All these compounds show one intense band (λabs max 300–440 nm). Compound 1 exhibits longest λabs max of 434 nm and 3 has the lowest λabs max of 341 nm. This absorption is due to the HOMO → LUMO (S0 → S1) transition (Fig. S4†). From solvatochromism data, these absorption is due to the π → π* transition. As compared to, ethenyl indole (3), the HOMO–LUMO optical band gap is decreased upon increasing the electron withdrawing or electron donating p-phenyl substitution. The energy band gap is decreased by 0.81 eV from phenyl ethenyl indole (3) to p-nitro phenyl ethenyl indole (1) [3.85 eV (for 3) to 3.05 eV (for 1)] (Fig. 5 and S5†). Similarly, the energy band gap is slightly decreased by 0.07 eV from phenyl ethenyl indole (3) to p-hydroxy phenyl ethenyl indole (5) [3.86 eV for 3 to 3.79 eV for 5], whereas the band gap is comparable for amino and methoxy substituent [3.86 eV for 3 to 3.84 eV for 4, 3.85 eV for 6]. Interestingly, N-ethyl substitution destabilized the ground and excited state of 1, whereas the ground and excited state is stabilized upon N-acetyl and N-sulfonyl substitution. Overall, the HOMO and LUMO energy of ethenyl indole, is progressively stabilized for electron withdrawing group due to the delocalization of π electron from indole to the p-phenyl ring (for NO2, Cl) (Fig. S6†). In case of electron donating substituents (methoxy, hydroxy and amino) (4–6), the destabilization of HOMO and LUMO energy level could be due to the hindrance in effective π conjugation.

Fig. 5. TDDFT computed molecular orbitals, optical band gap and HOMO–LUMO energy of 1–9.

Fig. 5

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3.4. Second order non-linear optical properties

The first hyperpolarizability coefficient (β) is related to the second order non-linear optical properties of the molecule. Thus, β of the compounds 1–9 is calculated in solvent, methanol using solvatochromism method. In general, non linear optical properties of the molecule is influenced by the delocalization of π electron. Thus, the effect of p-phenyl and N-substitution on the NLO response of the ethenyl indole 3 is studied. For this purpose, the absorption, oscillator strength (f), dipole moment (Δμ) and transition dipole moment (rg) of the molecules were calculated. It is shown that as compared to the reference compound 3, the β increases for strong electron withdrawing p-nitro phenyl substituent (Table 2, Fig. 6 and S7†). Compound 1 and 7–9, which have strong electron withdrawing p-nitro phenyl substituent, exhibit large β value. Similarly, as compared to 3, the β of other ethenyl increases slightly with increasing the electron donating nature of p-phenyl substitution. From previously report on 6-substituted indole based NLO materials, NLO response is also increased with increasing the donor ability of indole moiety through pyrrolidine ring.47,48 Compounds with weak electron donating or weak electron withdrawing substituent (Cl, OCH3, OH) (2, 4–5), however, exhibit a low β value as compared to nitro compounds, 1 and 7–9. The order of β obtained in ethenyl indoles with electron withdrawing group is NO2 (1, 7–9) > Cl (2) > H (3) and electron donating OH (5) > OCH3 (4) > NH2 (6) (β; 1: 115, 2: 20, 3: 9, 4: 17, 5: 24, 6: 9, 7: 106, 8: 43, 9: 87) (in 10−30 esu−1 cm5).

Fig. 6. Comparative chart of first hyperpolarizability (βCT), excited state dipole moment, change of excited state dipole moment, ground state dipole moment and optical band gap of 1–9.

Fig. 6

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The β value of some of the donor–acceptor nitro compounds, such as p-nitro aniline, 4-amino-4′-nitro stilbene, it is shown that the β value is increased from 20 to 100 (in 10−30 esu−1, cm5) with increasing the conjugation length and charge transfer nature of the molecule.28 From our previous report on thiophene and furan based conjugated compounds, similar results are also found.45,46 On the other hand, molecule with moderate or weak electron donor/acceptor substituent (cyano, chloro, methoxy, hydroxy), the effect on the β is very small as compared to the nitro substitution.45,46 For compound 7–9 with N-ethyl, N-acetyl and N-sulfonyl substituent, there is a hindrance in effective π conjugation, which leads to lower β value as compared to 1. The μg for 2–6 is in between 1.05–3.99 debye, whereas μg for 1, 7–9 is 4.34–9.32 debye (Tables S1–S3†). Thus, molecule with charge transfer behavior exhibits large ground state dipole moment, lower optical band gap and larger β value.

Overall, the β value is increased with (i) increasing the dipole moment, (ii) increasing the % of charge transfer behavior (iii) increasing the polarizability and (iv) with increasing the change of excited state dipole moment of 3-substituted indole compounds, whereas β value is decreased with (v) increasing the optical band gap of the molecule. It is the combination of all five factors involved in deciding the NLO response of the molecule. Mostly, for withdrawing substituent, the order of μg, μe, Δμ, π* and charge separation in 3-substituted indoles is NO2 (1, 7–9) > Cl (2) > H (3); and the order of β: NO2 (1, 7–9) > Cl (2) > H (3), where as for electron donating substituent, the order of μe, Δμ, π* and charge separation is OH (5) > OCH3 (4) > NH2 (6); and the order of β: OH (5) > OCH3 (4) > NH2 (6). On the other hand higher optical band gap reduced the β value. The order of optical band gap (ΔE) for electron withdrawing substituent: H (3) > Cl (2) > NO2 (1, 7–9) and the order of β is NO2 (1, 7–9) > Cl (2) > H (3). Similarly, the order ΔE for donating substituent: NH2 (6) > OCH3 (4) > OH (5) and the order of β: OH (5) > OCH3 (4) > NH2 (6). The optical band gap of N-substituted nitro compound (7–9) is little larger as compared to 1 and thus, NLO response of 7–9 is slightly lower as compared to compound 1.

4. Conclusion

In summary, it is shown that the excited state of ethenyl indole is highly sensitive to the solvent and the substituent present on it. Compound 1 and 7–9 with strong electron-attracting substituent exhibits charge transfer and highly dipolar excited state as compared to other ethenyls. Compound 2–6 with a moderate electron donating substituent or weak electron withdrawing or weak electron donating substituent exhibit non polar excited state and insensitive to solvent polarity. The energy band gap of 3 (phenyl ethenyl indole) is decreased by substituting either with an electron withdrawing (Cl, NO2) or an electron donating (OCH3, OH, NH2) substituent at the p-phenyl position. The compound with a strong electron accepting, p-nitrophenyl ethenyl indole shows 12 times better NLO response as compared to the reference ethenyl indole 3, whereas, for ethenyls 2–6 bearing a weak or moderately electron withdrawing or electron accepting substituent, exhibit lower NLO response. The β of ethenyl is increased with increasing the order of electron withdrawing nature of phenyl ring. On the other hand, in case of compounds bearing electron donating substituent shows comparable β value. The NLO response is also proportional to the ground state dipole moment, polarizability, dipolar nature and ionic character of the molecule, whereas it is inversely proportional to the optical band gap of the molecule. Overall, the optical properties of indole compound is highly dependent upon the substituent present in phenyl ring and N-substitution. In addition, studies on the macroscopic NLO properties of indole compound is an interesting aspect and a future prospective to look into. Thus, the above studies will help in designing and developing optical material for various electronic applications.

Conflicts of interest

There is no conflicts of interest to declare.

Supplementary Material

RA-010-D0RA05405D-s001

Acknowledgments

PKH, JK, NK are thankful to University Grants Commission, New Delhi for research grant (No. F.30-72/2014-BSR) and research fellowship. Authors acknowledged AMRC, IIT Mandi for 1H and 13C NMR facility.

†

Electronic supplementary information (ESI) available. See DOI: 10.1039/d0ra05405d

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RA-010-D0RA05405D-s001
RA-010-D0RA05405D-s001.pdf (1.5MB, pdf)

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